Janne Backman
Janne Backman
Professor in Clinical Pharmacology and Individual Medicine, University of Helsinki
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Drug interactions with lipid‐lowering drugs: mechanisms and clinical relevance
PJ Neuvonen, M Niemi, JT Backman
Clinical Pharmacology & Therapeutics 80 (6), 565-581, 2006
Pharmacokinetic interactions with rifampicin: clinical relevance
M Niemi, JT Backman, MF Fromm, PJ Neuvonen, KT Kivistö
Clinical pharmacokinetics 42, 819-850, 2003
High plasma pravastatin concentrations are associated with single nucleotide polymorphisms and haplotypes of organic anion transporting polypeptide-C (OATP-C, SLCO1B1)
M Niemi, E Schaeffeler, T Lang, MF Fromm, M Neuvonen, C Kyrklund, ...
Pharmacogenetics and Genomics 14 (7), 429-440, 2004
Midazolam should be avoided in patients receiving the systemic antimycotics ketoconazole or itraconazole
KT Olkkola, JT Backman, PJ Neuvonen
Clinical Pharmacology & Therapeutics 55 (5), 481-485, 1994
Polymorphic organic anion transporting polypeptide 1B1 is a major determinant of repaglinide pharmacokinetics
M Niemi, JT Backman, LI Kajosaari, JB Leathart, M Neuvonen, AK Daly, ...
Clinical Pharmacology & Therapeutics 77 (6), 468-478, 2005
Gemfibrozil greatly increases plasma concentrations of cerivastatin
JT Backman, C Kyrklund, M Neuvonen, PJ Neuvonen
Clinical Pharmacology & Therapeutics 72 (6), 685-691, 2002
Effects of gemfibrozil, itraconazole, and their combination on the pharmacokinetics and pharmacodynamics of repaglinide: potentially hazardous interaction between gemfibrozil …
M Niemi, JT Backman, M Neuvonen, PJ Neuvonen
Diabetologia 46, 347-351, 2003
Simvastatin decreases lipopolysaccharide-induced pulmonary inflammation in healthy volunteers
M Shyamsundar, STW McKeown, CM O'Kane, TR Craig, V Brown, ...
American journal of respiratory and critical care medicine 179 (12), 1107-1114, 2009
Plasma concentrations of active simvastatin acid are increased by gemfibrozil
JT Backman, C Kyrklund, KT Kivistö, JS Wang, PJ Neuvonen
Clinical Pharmacology & Therapeutics 68 (2), 122-129, 2000
Rifampin drastically reduces plasma concentrations and effects of oral midazolam
JT Backman, KT Olkkola, PJ Neuvonen
Clinical pharmacology & therapeutics 59 (1), 7-13, 1996
The area under the plasma concentration–time curve for oral midazolam is 400-fold larger during treatment with itraconazole than with rifampicin
JT Backman, KT Kivistö, KT Olkkola, PJ Neuvonen
European journal of clinical pharmacology 54, 53-58, 1998
Pharmacokinetic comparison of the potential over-the-counter statins simvastatin, lovastatin, fluvastatin and pravastatin
PJ Neuvonen, JT Backman, M Niemi
Clinical pharmacokinetics 47, 463-474, 2008
Expression of cyclooxygenase 1 and cyclooxygenase 2 in human synovial tissue: differential elevation of cyclooxygenase 2 in inflammatory joint diseases
I Siegle, T Klein, JT Backman, JG Saal, RM Nüsing, P Fritz
Arthritis & Rheumatism: Official Journal of the American College of …, 1998
Cyclosporine markedly raises the plasma concentrations of repaglinide
LI Kajosaari, M Niemi, M Neuvonen, J Laitila, PJ Neuvonen, JT Backman
Clinical Pharmacology & Therapeutics 78 (4), 388-399, 2005
Gemfibrozil considerably increases the plasma concentrations of rosiglitazone
M Niemi, JT Backman, M Granfors, J Laitila, M Neuvonen, PJ Neuvonen
Diabetologia 46, 1319-1323, 2003
The role of β-glucuronidase in drug disposition and drug targeting in humans
B Sperker, JT Backman, HK Kroemer
Clinical pharmacokinetics 33, 18-31, 1997
Polymorphism in CYP2C8 is associated with reduced plasma concentrations of repaglinide
M Niemi, JB Leathart, M Neuvonen, JT Backman, AK Daly, PJ Neuvonen
Clinical Pharmacology & Therapeutics 74 (4), 380-387, 2003
Plasma concentrations of active lovastatin acid are markedly increased by gemfibrozil but not by bezafibrate
C Kyrklund, JT Backman, KT Kivistö, M Neuvonen, J Laitila, PJ Neuvonen
Clinical Pharmacology & Therapeutics 69 (5), 340-345, 2001
Dose of midazolam should be reduced during diltiazem and verapamil treatments.
JT Backman, KT Olkkola, K Aranko, JJ Himberg, PJ Neuvonen
British journal of clinical pharmacology 37 (3), 221-225, 1994
Gemfibrozil increases plasma pravastatin concentrations and reduces pravastatin renal clearance
C Kyrklund, JT Backman, M Neuvonen, PJ Neuvonen
Clinical Pharmacology & Therapeutics 73 (6), 538-544, 2003
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