| Chronic obstructive pulmonary disease: molecular and cellularmechanisms PJ Barnes, SD Shapiro, RA Pauwels European Respiratory Journal 22 (4), 672-688, 2003 | 2208 | 2003 |
| MMP-9/gelatinase B is a key regulator of growth plate angiogenesis and apoptosis of hypertrophic chondrocytes TH Vu, JM Shipley, G Bergers, JE Berger, JA Helms, D Hanahan, ... Cell 93 (3), 411-422, 1998 | 2135 | 1998 |
| Requirement for macrophage elastase for cigarette smoke-induced emphysema in mice RD Hautamaki, DK Kobayashi, RM Senior, SD Shapiro Science 277 (5334), 2002-2004, 1997 | 1785 | 1997 |
| Targeted gene disruption of matrix metalloproteinase-9 (gelatinase B) suppresses development of experimental abdominal aortic aneurysms R Pyo, JK Lee, JM Shipley, JA Curci, D Mao, SJ Ziporin, TL Ennis, ... The Journal of clinical investigation 105 (11), 1641-1649, 2000 | 1041 | 2000 |
| A randomized, controlled trial of protocol-directed versus physician-directed weaning from mechanical ventilation MH Kollef, SD Shapiro, P Silver, RES John, D Prentice, S Sauer, ... Critical care medicine 25 (4), 567-574, 1997 | 1011 | 1997 |
| Matrix metalloproteinase degradation of extracellular matrix: biological consequences SD Shapiro Current opinion in cell biology 10 (5), 602-608, 1998 | 978 | 1998 |
| Mice lacking neutrophil elastase reveal impaired host defense against gram negative bacterial sepsis A Belaaouaj, R McCarthy, M Baumann, Z Gao, TJ Ley, SN Abraham, ... Nature medicine 4 (5), 615-618, 1998 | 825 | 1998 |
| Inducible targeting of IL-13 to the adult lung causes matrix metalloproteinase–and cathepsin-dependent emphysema T Zheng, Z Zhu, Z Wang, RJ Homer, B Ma, RJ Riese, HA Chapman, ... The Journal of clinical investigation 106 (9), 1081-1093, 2000 | 818 | 2000 |
| Neutrophil elastase–mediated degradation of IRS-1 accelerates lung tumor growth AMG Houghton, DM Rzymkiewicz, H Ji, AD Gregory, EE Egea, HE Metz, ... Nature medicine 16 (2), 219-223, 2010 | 800 | 2010 |
| Marked longevity of human lung parenchymal elastic fibers deduced from prevalence of D-aspartate and nuclear weapons-related radiocarbon. SD Shapiro, SK Endicott, MA Province, JA Pierce, EJ Campbell The Journal of clinical investigation 87 (5), 1828-1834, 1991 | 713 | 1991 |
| Human 92-and 72-kilodalton type IV collagenases are elastases. RM Senior, GL Griffin, CJ Fliszar, SD Shapiro, GI Goldberg, HG Welgus Journal of Biological Chemistry 266 (12), 7870-7875, 1991 | 687 | 1991 |
| Tumor cell traffic through the extracellular matrix is controlled by the membrane-anchored collagenase MT1-MMP F Sabeh, I Ota, K Holmbeck, H Birkedal-Hansen, P Soloway, M Balbin, ... The Journal of cell biology 167 (4), 769-781, 2004 | 681 | 2004 |
| Neutrophil elastase contributes to cigarette smoke-induced emphysema in mice SD Shapiro, NM Goldstein, AMG Houghton, DK Kobayashi, D Kelley, ... The American journal of pathology 163 (6), 2329-2335, 2003 | 644 | 2003 |
| Cloning and characterization of a unique elastolytic metalloproteinase produced by human alveolar macrophages. SD Shapiro, DK Kobayashi, TJ Ley Journal of Biological Chemistry 268 (32), 23824-23829, 1993 | 634 | 1993 |
| Leukocyte-derived matrix metalloproteinase-9 mediates blood-brain barrier breakdown and is proinflammatory after transient focal cerebral ischemia JM Gidday, YG Gasche, JC Copin, AR Shah, RS Perez, SD Shapiro, ... American Journal of Physiology-Heart and Circulatory Physiology 289 (2 …, 2005 | 630 | 2005 |
| Loss of integrin αvβ6-mediated TGF-β activation causes Mmp12-dependent emphysema DG Morris, X Huang, N Kaminski, Y Wang, SD Shapiro, G Dolganov, ... Nature 422 (6928), 169-173, 2003 | 615 | 2003 |
| Loss of collagenase-2 confers increased skin tumor susceptibility to male mice M Balbín, A Fueyo, AM Tester, AM Pendás, AS Pitiot, A Astudillo, ... Nature genetics 35 (3), 252-257, 2003 | 598 | 2003 |
| Metalloelastase is required for macrophage-mediated proteolysis and matrix invasion in mice. JM Shipley, RL Wesselschmidt, DK Kobayashi, TJ Ley, SD Shapiro Proceedings of the National Academy of Sciences 93 (9), 3942-3946, 1996 | 598 | 1996 |
| Pathogenetic sequence for aneurysm revealed in mice underexpressing fibrillin-1 L Pereira, SY Lee, B Gayraud, K Andrikopoulos, SD Shapiro, T Bunton, ... Proceedings of the National Academy of Sciences 96 (7), 3819-3823, 1999 | 596 | 1999 |
| Matrix metalloproteinases generate angiostatin: effects on neovascularization LA Cornelius, LC Nehring, E Harding, M Bolanowski, HG Welgus, ... The Journal of Immunology 161 (12), 6845-6852, 1998 | 591 | 1998 |
