Evan P Lebois
Evan P Lebois
Broad Institute of MIT and Harvard, Stanley Center for Psychiatric Research
Verified email at broadinstitute.org
Title
Cited by
Cited by
Year
Novel allosteric agonists of M1 muscarinic acetylcholine receptors induce brain region-specific responses that correspond with behavioral effects in animal models
GJ Digby, MJ Noetzel, M Bubser, TJ Utley, AG Walker, NE Byun, ...
Journal of Neuroscience 32 (25), 8532-8544, 2012
1002012
Discovery and Characterization of Novel Subtype-Selective Allosteric Agonists for the Investigation of M1 Receptor Function in the Central Nervous System
EP Lebois, TM Bridges, LM Lewis, ES Dawson, AS Kane, Z Xiang, ...
ACS chemical neuroscience 1 (2), 104-121, 2010
942010
Allosteric modulation of kinases and GPCRs: design principles and structural diversity
JA Lewis, EP Lebois, CW Lindsley
Current opinion in chemical biology 12 (3), 269-280, 2008
812008
Microwave-assisted protocols for the expedited synthesis of pyrazolo [1, 5-a] and [3, 4-d] pyrimidines
RN Daniels, K Kim, EP Lebois, H Muchalski, M Hughes, CW Lindsley
Tetrahedron Letters 49 (2), 305-310, 2008
722008
Positive allosteric modulators of the metabotropic glutamate receptor subtype 4 (mGluR4): Part I. Discovery of pyrazolo[3,4-d]pyrimidines as novel mGluR4 positive …
CM Niswender, EP Lebois, Q Luo, K Kim, H Muchalski, H Yin, PJ Conn, ...
Bioorganic & medicinal chemistry letters 18 (20), 5626-5630, 2008
652008
Muscarinic receptor subtype distribution in the central nervous system and relevance to aging and Alzheimer's disease
EP Lebois, C Thorn, JR Edgerton, M Popiolek, S Xi
Neuropharmacology 136, 362-373, 2018
582018
The antipsychotic potential of muscarinic allosteric modulation
TM Bridges, EP LeBois, CR Hopkins, MR Wood, CK Jones, PJ Conn, ...
Drug news & perspectives 23 (4), 229, 2010
552010
Effects of selective activation of M1 and M4 muscarinic receptors on object recognition memory performance in rats
CR Galloway, EP Lebois, SL Shagarabi, NA Hernandez, JR Manns
Pharmacology 93 (1-2), 57-64, 2014
302014
The evolution of histamine H3 antagonists/inverse agonists
E P Lebois, C K Jones, C W Lindsley
Current topics in medicinal chemistry 11 (6), 648-660, 2011
302011
Development of a highly selective, orally bioavailable and CNS penetrant M1 agonist derived from the MLPCN probe ML071
EP Lebois, GJ Digby, DJ Sheffler, BJ Melancon, JC Tarr, HP Cho, ...
Bioorganic & medicinal chemistry letters 21 (21), 6451-6455, 2011
292011
Chemical Modification of the M1 Agonist VU0364572 Reveals Molecular Switches in Pharmacology and a Bitopic Binding Mode
GJ Digby, TJ Utley, A Lamsal, C Sevel, DJ Sheffler, EP Lebois, ...
ACS chemical neuroscience 3 (12), 1025-1036, 2012
282012
Disease-Modifying Effects of M1 Muscarinic Acetylcholine Receptor Activation in an Alzheimer’s Disease Mouse Model
EP Lebois, JP Schroeder, TJ Esparza, TM Bridges, CW Lindsley, PJ Conn, ...
ACS chemical neuroscience 8 (6), 1177-1187, 2017
252017
From engrams to pathologies of the brain
CA Denny, E Lebois, S Ramirez
Frontiers in neural circuits 11, 23, 2017
232017
MAOS protocols for the general synthesis and lead optimization of 3, 6-disubstituted-[1, 2, 4] triazolo [4, 3-b] pyridazines
LN Aldrich, EP Lebois, LM Lewis, NT Nalywajko, CM Niswender, ...
Tetrahedron letters 50 (2), 212-215, 2009
182009
Continued optimization of the MLPCN probe ML071 into highly potent agonists of the hM1 muscarinic acetylcholine receptor
BJ Melancon, RD Gogliotti, JC Tarr, SA Saleh, BA Chauder, EP Lebois, ...
Bioorganic & medicinal chemistry letters 22 (10), 3467-3472, 2012
162012
The reverse translation of a quantitative neuropsychiatric framework into preclinical studies: Focus on social interaction and behavior
T Peleh, KGO Ike, EJ Wams, EP Lebois, B Hengerer
Neuroscience & Biobehavioral Reviews 97, 96-111, 2019
82019
Alkyl 3-((2-amidoethyl) amino)-8-azabicyclo [3.2. 1] octane-8-carboxylate analogs as selective M1 agonists and methods of making and using same
PJ Conn, CW Lindsley, MR Wood, RD Gogliotti, CM Niswender, ...
US Patent 8,697,691, 2014
82014
Effects of Selective M1 Muscarinic Receptor Activation on Hippocampal Spatial Representations and Neuronal Oscillations
EP Lebois, JB Trimper, C Hu, AI Levey, JR Manns
ACS chemical neuroscience 7 (10), 1393-1405, 2016
72016
Hippocampal place cell dysfunction and the effects of muscarinic M1 receptor agonism in a rat model of Alzheimer's disease
CR Galloway, K Ravipati, S Singh, EP Lebois, RM Cohen, AI Levey, ...
Hippocampus 28 (8), 568-585, 2018
22018
Molecule of the Month
EP Lebois
Current topics in medicinal chemistry 8 (16), 1480-1481, 2008
22008
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