| Novel allosteric agonists of M1 muscarinic acetylcholine receptors induce brain region-specific responses that correspond with behavioral effects in animal models GJ Digby, MJ Noetzel, M Bubser, TJ Utley, AG Walker, NE Byun, ... Journal of Neuroscience 32 (25), 8532-8544, 2012 | 100 | 2012 |
| Discovery and Characterization of Novel Subtype-Selective Allosteric Agonists for the Investigation of M1 Receptor Function in the Central Nervous System EP Lebois, TM Bridges, LM Lewis, ES Dawson, AS Kane, Z Xiang, ... ACS chemical neuroscience 1 (2), 104-121, 2010 | 94 | 2010 |
| Allosteric modulation of kinases and GPCRs: design principles and structural diversity JA Lewis, EP Lebois, CW Lindsley Current opinion in chemical biology 12 (3), 269-280, 2008 | 81 | 2008 |
| Microwave-assisted protocols for the expedited synthesis of pyrazolo [1, 5-a] and [3, 4-d] pyrimidines RN Daniels, K Kim, EP Lebois, H Muchalski, M Hughes, CW Lindsley Tetrahedron Letters 49 (2), 305-310, 2008 | 72 | 2008 |
| Positive allosteric modulators of the metabotropic glutamate receptor subtype 4 (mGluR4): Part I. Discovery of pyrazolo[3,4-d]pyrimidines as novel mGluR4 positive … CM Niswender, EP Lebois, Q Luo, K Kim, H Muchalski, H Yin, PJ Conn, ... Bioorganic & medicinal chemistry letters 18 (20), 5626-5630, 2008 | 65 | 2008 |
| Muscarinic receptor subtype distribution in the central nervous system and relevance to aging and Alzheimer's disease EP Lebois, C Thorn, JR Edgerton, M Popiolek, S Xi Neuropharmacology 136, 362-373, 2018 | 58 | 2018 |
| The antipsychotic potential of muscarinic allosteric modulation TM Bridges, EP LeBois, CR Hopkins, MR Wood, CK Jones, PJ Conn, ... Drug news & perspectives 23 (4), 229, 2010 | 55 | 2010 |
| Effects of selective activation of M1 and M4 muscarinic receptors on object recognition memory performance in rats CR Galloway, EP Lebois, SL Shagarabi, NA Hernandez, JR Manns Pharmacology 93 (1-2), 57-64, 2014 | 30 | 2014 |
| The evolution of histamine H3 antagonists/inverse agonists E P Lebois, C K Jones, C W Lindsley Current topics in medicinal chemistry 11 (6), 648-660, 2011 | 30 | 2011 |
| Development of a highly selective, orally bioavailable and CNS penetrant M1 agonist derived from the MLPCN probe ML071 EP Lebois, GJ Digby, DJ Sheffler, BJ Melancon, JC Tarr, HP Cho, ... Bioorganic & medicinal chemistry letters 21 (21), 6451-6455, 2011 | 29 | 2011 |
| Chemical Modification of the M1 Agonist VU0364572 Reveals Molecular Switches in Pharmacology and a Bitopic Binding Mode GJ Digby, TJ Utley, A Lamsal, C Sevel, DJ Sheffler, EP Lebois, ... ACS chemical neuroscience 3 (12), 1025-1036, 2012 | 28 | 2012 |
| Disease-Modifying Effects of M1 Muscarinic Acetylcholine Receptor Activation in an Alzheimer’s Disease Mouse Model EP Lebois, JP Schroeder, TJ Esparza, TM Bridges, CW Lindsley, PJ Conn, ... ACS chemical neuroscience 8 (6), 1177-1187, 2017 | 25 | 2017 |
| From engrams to pathologies of the brain CA Denny, E Lebois, S Ramirez Frontiers in neural circuits 11, 23, 2017 | 23 | 2017 |
| MAOS protocols for the general synthesis and lead optimization of 3, 6-disubstituted-[1, 2, 4] triazolo [4, 3-b] pyridazines LN Aldrich, EP Lebois, LM Lewis, NT Nalywajko, CM Niswender, ... Tetrahedron letters 50 (2), 212-215, 2009 | 18 | 2009 |
| Continued optimization of the MLPCN probe ML071 into highly potent agonists of the hM1 muscarinic acetylcholine receptor BJ Melancon, RD Gogliotti, JC Tarr, SA Saleh, BA Chauder, EP Lebois, ... Bioorganic & medicinal chemistry letters 22 (10), 3467-3472, 2012 | 16 | 2012 |
| The reverse translation of a quantitative neuropsychiatric framework into preclinical studies: Focus on social interaction and behavior T Peleh, KGO Ike, EJ Wams, EP Lebois, B Hengerer Neuroscience & Biobehavioral Reviews 97, 96-111, 2019 | 8 | 2019 |
| Alkyl 3-((2-amidoethyl) amino)-8-azabicyclo [3.2. 1] octane-8-carboxylate analogs as selective M1 agonists and methods of making and using same PJ Conn, CW Lindsley, MR Wood, RD Gogliotti, CM Niswender, ... US Patent 8,697,691, 2014 | 8 | 2014 |
| Effects of Selective M1 Muscarinic Receptor Activation on Hippocampal Spatial Representations and Neuronal Oscillations EP Lebois, JB Trimper, C Hu, AI Levey, JR Manns ACS chemical neuroscience 7 (10), 1393-1405, 2016 | 7 | 2016 |
| Hippocampal place cell dysfunction and the effects of muscarinic M1 receptor agonism in a rat model of Alzheimer's disease CR Galloway, K Ravipati, S Singh, EP Lebois, RM Cohen, AI Levey, ... Hippocampus 28 (8), 568-585, 2018 | 2 | 2018 |
| Molecule of the Month EP Lebois Current topics in medicinal chemistry 8 (16), 1480-1481, 2008 | 2 | 2008 |
