Exit from dormancy provokes DNA-damage-induced attrition in haematopoietic stem cells D Walter, A Lier, A Geiselhart, FB Thalheimer, S Huntscha, MC Sobotta, ... Nature 520 (7548), 549-552, 2015 | 388 | 2015 |
Identification of regulatory networks in HSCs and their immediate progeny via integrated proteome, transcriptome, and DNA methylome analysis N Cabezas-Wallscheid, D Klimmeck, J Hansson, DB Lipka, A Reyes, ... Cell stem cell 15 (4), 507-522, 2014 | 329 | 2014 |
Inflammation-induced emergency megakaryopoiesis driven by hematopoietic stem cell-like megakaryocyte progenitors S Haas, J Hansson, D Klimmeck, D Loeffler, L Velten, H Uckelmann, ... Cell stem cell 17 (4), 422-434, 2015 | 220 | 2015 |
Overcoming reprogramming resistance of Fanconi anemia cells LUW Müller, MD Milsom, CE Harris, R Vyas, KM Brumme, K Parmar, ... Blood 119 (23), 5449-5457, 2012 | 146 | 2012 |
Requirement for CDK6 in MLL-rearranged acute myeloid leukemia T Placke, K Faber, A Nonami, SL Putwain, HR Salih, FH Heidel, A Krämer, ... Blood 124 (1), 13-23, 2014 | 145 | 2014 |
Multicistronic lentiviral vectors containing the FMDV 2A cleavage factor demonstrate robust expression of encoded genes at limiting MOI D Chinnasamy, MD Milsom, J Shaffer, J Neuenfeldt, AF Shaaban, ... Virology Journal 3 (1), 14, 2006 | 112 | 2006 |
Causes and consequences of hematopoietic stem cell heterogeneity S Haas, A Trumpp, MD Milsom Cell Stem Cell 22 (5), 627-638, 2018 | 96 | 2018 |
Lineage-specific BCL11A knockdown circumvents toxicities and reverses sickle phenotype C Brendel, S Guda, R Renella, DE Bauer, MC Canver, YJ Kim, ... The Journal of clinical investigation 126 (10), 3868-3878, 2016 | 95 | 2016 |
miRNA-embedded shRNAs for lineage-specific BCL11A knockdown and hemoglobin F induction S Guda, C Brendel, R Renella, P Du, DE Bauer, MC Canver, JK Grenier, ... Molecular Therapy 23 (9), 1465-1474, 2015 | 87 | 2015 |
Platelet GPIbα is a mediator and potential interventional target for NASH and subsequent liver cancer M Malehmir, D Pfister, S Gallage, M Szydlowska, D Inverso, E Kotsiliti, ... Nature medicine 25 (4), 641-655, 2019 | 71 | 2019 |
Rac1 is essential for intraembryonic hematopoiesis and for the initial seeding of fetal liver with definitive hematopoietic progenitor cells G Ghiaur, MJ Ferkowicz, MD Milsom, J Bailey, D Witte, JA Cancelas, ... Blood, The Journal of the American Society of Hematology 111 (7), 3313-3321, 2008 | 61 | 2008 |
The European Hematology Association Roadmap for European Hematology Research: a consensus documentThe EHA Roadmap for European Hematology ResearchThe EHA Roadmap for European … A Engert, C Balduini, A Brand, B Coiffier, C Cordonnier, H Döhner, ... haematologica 101 (2), 115-208, 2016 | 57 | 2016 |
Rapid lentiviral transduction preserves the engraftment potential of Fanca−/− hematopoietic stem cells LUW Müller, MD Milsom, MO Kim, A Schambach, T Schuesler, ... Molecular Therapy 16 (6), 1154-1160, 2008 | 49 | 2008 |
Enhanced in vivo selection of bone marrow cells by retroviral-mediated coexpression of mutant O6-methylguanine-DNA-methyltransferase and HOXB4 MD Milsom, LB Woolford, GP Margison, RK Humphries, LJ Fairbairn Molecular Therapy 10 (5), 862-873, 2004 | 42 | 2004 |
Stem cell-specific mechanisms ensure genomic fidelity within HSCs and upon aging of HSCs BM Moehrle, K Nattamai, A Brown, MC Florian, M Ryan, M Vogel, ... Cell reports 13 (11), 2412-2424, 2015 | 40 | 2015 |
The P140K mutant of human O6‐methylguanine‐DNA‐methyltransferase (MGMT) confers resistance in vitro and in vivo to temozolomide in combination with the novel MGMT inactivator … LB Woolford, TD Southgate, GP Margison, MD Milsom, LJ Fairbairn The Journal of Gene Medicine: A cross‐disciplinary journal for research on …, 2006 | 40 | 2006 |
Live and let die: in vivo selection of gene-modified hematopoietic stem cells via MGMT-mediated chemoprotection MD Milsom, DA Williams DNA repair 6 (8), 1210-1221, 2007 | 36 | 2007 |
Early aberrant DNA methylation events in a mouse model of acute myeloid leukemia M Sonnet, R Claus, N Becker, M Zucknick, J Petersen, DB Lipka, ... Genome medicine 6 (4), 1-16, 2014 | 34 | 2014 |
The Rac GTPase effector p21-activated kinase is essential for hematopoietic stem/progenitor cell migration and engraftment AM Dorrance, S De Vita, M Radu, PNG Reddy, MK McGuinness, ... Blood, The Journal of the American Society of Hematology 121 (13), 2474-2482, 2013 | 34 | 2013 |
Clonal evolution of preleukemic hematopoietic stem cells in acute myeloid leukemia SM Sykes, KD Kokkaliaris, MD Milsom, RL Levine, R Majeti Experimental hematology 43 (12), 989-992, 2015 | 32 | 2015 |