Costi Maria Paola
Costi Maria Paola
Medicinal chemistry professor University of Modena and Reggio Emilia
Bestätigte E-Mail-Adresse bei - Startseite
Zitiert von
Zitiert von
Comprehensive mechanistic analysis of hits from high-throughput and docking screens against β-lactamase
K Babaoglu, A Simeonov, JJ Irwin, ME Nelson, B Feng, CJ Thomas, ...
Journal of medicinal chemistry 51 (8), 2502-2511, 2008
The Hippo Pathway and YAP/TAZ–TEAD Protein–Protein Interaction as Targets for Regenerative Medicine and Cancer Treatment: Miniperspective
M Santucci, T Vignudelli, S Ferrari, M Mor, L Scalvini, ML Bolognesi, ...
Journal of medicinal chemistry 58 (12), 4857-4873, 2015
Discovery of potent pteridine reductase inhibitors to guide antiparasite drug development
A Cavazzuti, G Paglietti, WN Hunter, F Gamarro, S Piras, M Loriga, ...
Proceedings of the National Academy of Sciences 105 (5), 1448, 2008
Discovery of highly potent acid ceramidase inhibitors with in vitro tumor chemosensitizing activity
N Realini, C Solorzano, C Pagliuca, D Pizzirani, A Armirotti, R Luciani, ...
Scientific reports 3 (1), 1035, 2013
2-Carboxyquinoxalines Kill Mycobacterium tuberculosis through Noncovalent Inhibition of DprE1
J Neres, RC Hartkoorn, LR Chiarelli, R Gadupudi, MR Pasca, G Mori, ...
ACS chemical biology 10 (3), 705-714, 2015
Thymidylate synthase structure, function and implication in drug discovery
MP Costi, S Ferrari, A Venturelli, S Calo, D Tondi, D Barlocco
Current medicinal chemistry 12 (19), 2241-2258, 2005
Protein-protein interface-binding peptides inhibit the cancer therapy target human thymidylate synthase.
CMP Cardinale D, Guaitoli G, Tondi D, Luciani R
Proceeding National Academy of Science 108, 16133, 2011
Virtual Screening Identification of Nonfolate Compounds, Including a CNS Drug, as Antiparasitic Agents Inhibiting Pteridine Reductase
S Ferrari, F Morandi, D Motiejunas, E Nerini, S Henrich, R Luciani, ...
Journal of medicinal chemistry, 2011
Structure-based discovery and in-parallel optimization of novelcompetitive inhibitors of thymidylate synthase
D Tondi, U Slomczynska, MP Costi, DM Watterson, S Ghelli, BK Shoichet
Chemistry & biology 6 (5), 319-331, 1999
Update on antifolate drugs targets
MP Costi, S Ferrari
Current drug targets 2 (2), 135-166, 2001
Structure-based optimization of a non-β-lactam lead results in inhibitors that do not up-regulate β-lactamase expression in cell culture
D Tondi, F Morandi, R Bonnet, MP Costi, BK Shoichet
Journal of the American Chemical Society 127 (13), 4632-4639, 2005
Structure-based design and in-parallel synthesis of inhibitors of AmpC β-lactamase
D Tondi, RA Powers, E Caselli, MC Negri, J Blázquez, MP Costi, ...
Chemistry & Biology 8 (6), 593-610, 2001
Inside the biochemical pathways of thymidylate synthase perturbed by anticancer drugs: Novel strategies to overcome cancer chemoresistance
L Taddia, D D’Arca, S Ferrari, C Marraccini, L Severi, G Ponterini, ...
Drug Resistance Updates 23, 20-54, 2015
Structure-Based Design of Inhibitors Specific for Bacterial Thymidylate Synthase,
TJ Stout, D Tondi, M Rinaldi, D Barlocco, P Pecorari, DV Santi, ID Kuntz, ...
Biochemistry 38 (5), 1607-1617, 1999
Combination of Suboptimal Doses of Inhibitors Targeting Different Domains of LtrMDR1 Efficiently Overcomes Resistance of Leishmania spp. to Miltefosine by …
JM Pérez-Victoria, F Cortés-Selva, A Parodi-Talice, BI Bavchvarov, ...
Antimicrobial agents and chemotherapy 50 (9), 3102-3110, 2006
Novel approaches for targeting thymidylate synthase to overcome the resistance and toxicity of anticancer drugs
D Garg, S Henrich, OMH Salo-Ahen, H Myllykallio, MP Costi, RC Wade
Journal of medicinal chemistry 53 (18), 6539-6549, 2010
Modulation of the expression of folate cycle enzymes and polyamine metabolism by berberine in cisplatin-sensitive and-resistant human ovarian cancer cells
G Marverti, A Ligabue, P Lombardi, S Ferrari, MG Monti, C Frassineti, ...
International Journal of Oncology 43 (4), 1269-1280, 2013
Novel 3‐benzoyl‐2‐piperazinylquinoxaline derivatives as potential antitumor agents
S Piras, M Loriga, A Carta, G Paglietti, M Paola Costi, S Ferrari
Journal of heterocyclic chemistry 43 (3), 541-548, 2006
Current and future chemotherapy for Chagas disease
L Gaspar, C B Moraes, L H Freitas-Junior, S Ferrari, L Costantino, ...
Current medicinal chemistry 22 (37), 4293-4312, 2015
Homodimeric enzymes as drug targets
D Cardinale, OMH Salo-Ahen, S Ferrari, G Ponterini, G Cruciani, ...
Current medicinal chemistry 17 (9), 826-846, 2010
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