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Katherine A Donovan
Katherine A Donovan
Dana-Farber Cancer Institute, Harvard Medical School
Verified email at crystal.harvard.edu
Title
Cited by
Cited by
Year
Plasticity in binding confers selectivity in ligand-induced protein degradation
RP Nowak, SL DeAngelo, D Buckley, Z He, KA Donovan, J An, N Safaee, ...
Nature chemical biology 14 (7), 706-714, 2018
4342018
Thalidomide promotes degradation of SALL4, a transcription factor implicated in Duane Radial Ray Syndrome
KA Donovan, J An, RP Nowak, JC Yuan, EC Fink, BC Berry, BL Ebert, ...
eLife 7, e38430, 2018
3432018
The CDK inhibitor CR8 acts as a molecular glue degrader that depletes cyclin K
M Słabicki, Z Kozicka, G Petzold, YD Li, M Manojkumar, RD Bunker, ...
Nature 585 (7824), 293-297, 2020
2422020
Targeted degradation of aberrant tau in frontotemporal dementia patient-derived neuronal cell models
MC Silva, FM Ferguson, Q Cai, KA Donovan, G Nandi, D Patnaik, T Zhang, ...
eLife 8, e45457, 2019
2102019
Development of dual and selective degraders of cyclin‐dependent kinases 4 and 6
B Jiang, ES Wang, KA Donovan, Y Liang, ES Fischer, T Zhang, NS Gray
Angewandte Chemie International Edition 58 (19), 6321-6326, 2019
2012019
Exploring Targeted Degradation Strategy for Oncogenic KRASG12C
M Zeng, Y Xiong, N Safaee, RP Nowak, KA Donovan, CJ Yuan, B Nabet, ...
Cell Chemical Biology 27 (1), 19-31. e6, 2020
2002020
Homolog-Selective Degradation as a Strategy to Probe the Function of CDK6 in AML
M Brand, B Jiang, S Bauer, KA Donovan, Y Liang, ES Wang, RP Nowak, ...
Cell chemical biology 26 (2), 300-306. e9, 2019
1982019
Chemically Induced Degradation of Anaplastic Lymphoma Kinase (ALK)
CE Powell, Y Gao, L Tan, KA Donovan, RP Nowak, A Loehr, M Bahcall, ...
Journal of medicinal chemistry 61 (9), 4249-4255, 2018
1792018
Mapping the Degradable Kinome Provides a Resource for Expedited Degrader Development
KA Donovan, FM Ferguson, JW Bushman, NA Eleuteri, D Bhunia, SS Ryu, ...
Cell 183 (6), 1714-1731. e10, 2020
1682020
Small-molecule-induced polymerization triggers degradation of BCL6
M Słabicki, H Yoon, J Koeppel, L Nitsch, SS Roy Burman, C Di Genua, ...
Nature 588 (7836), 164-168, 2020
1502020
Structural complementarity facilitates E7820-mediated degradation of RBM39 by DCAF15
TB Faust, H Yoon, RP Nowak, KA Donovan, Z Li, Q Cai, NA Eleuteri, ...
Nature chemical biology 16 (1), 7-14, 2020
1492020
Small molecule degraders of the hepatitis C virus protease reduce susceptibility to resistance mutations
M de Wispelaere, G Du, KA Donovan, T Zhang, NA Eleuteri, JC Yuan, ...
Nature communications 10 (1), 3468, 2019
1442019
pSILAC mass spectrometry reveals ZFP91 as IMiD-dependent substrate of the CRL4CRBN ubiquitin ligase
J An, CM Ponthier, R Sack, J Seebacher, MB Stadler, KA Donovan, ...
Nature communications 8 (1), 15398, 2017
1422017
Bruton tyrosine kinase degradation as a therapeutic strategy for cancer
D Dobrovolsky, ES Wang, S Morrow, C Leahy, T Faust, RP Nowak, ...
Blood, The Journal of the American Society of Hematology 133 (9), 952-961, 2019
1402019
Discovery of an AKT Degrader with Prolonged Inhibition of Downstream Signaling
I You, EC Erickson, KA Donovan, NA Eleuteri, ES Fischer, NS Gray, ...
Cell Chemical Biology 27 (1), 66-73. e7, 2020
942020
ER stress signaling promotes the survival of cancer “persister cells” tolerant to EGFR tyrosine kinase inhibitors
H Terai, S Kitajima, DS Potter, Y Matsui, LG Quiceno, T Chen, T Kim, ...
Cancer research 78 (4), 1044-1057, 2018
852018
INK4 tumor suppressor proteins mediate resistance to CDK4/6 kinase inhibitors
Q Li, B Jiang, J Guo, H Shao, IS Del Priore, Q Chang, R Kudo, Z Li, ...
Cancer Discovery 12 (2), 356-371, 2022
792022
Development and Characterization of a Wee1 Kinase Degrader
Z Li, BJ Pinch, CM Olson, KA Donovan, RP Nowak, CE Mills, DA Scott, ...
Cell Chemical Biology 27 (1), 57-65. e9, 2020
742020
Acute pharmacological degradation of Helios destabilizes regulatory T cells
ES Wang, AL Verano, RP Nowak, JC Yuan, KA Donovan, NA Eleuteri, ...
Nature Chemical Biology 17 (6), 711-717, 2021
562021
Selective Degradation of GSPT1 by Cereblon Modulators Identified via a Focused Combinatorial Library
CE Powell, G Du, J Che, Z He, KA Donovan, H Yue, ES Wang, RP Nowak, ...
ACS Chemical Biology 15 (10), 2722-2730, 2020
532020
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