| Combinatorial CRISPR–Cas9 screens for de novo mapping of genetic interactions JP Shen, D Zhao, R Sasik, J Luebeck, A Birmingham, ... Nature methods 14 (6), 573-576, 2017 | 359 | 2017 |
| Soluble TREM2 ameliorates pathological phenotypes by modulating microglial functions in an Alzheimer’s disease model L Zhong, Y Xu, R Zhuo, T Wang, K Wang, R Huang, D Wang, Y Gao, ... Nature communications 10 (1), 1365, 2019 | 243 | 2019 |
| The tight junction protein, occludin, regulates the directional migration of epithelial cells D Du, F Xu, L Yu, C Zhang, X Lu, H Yuan, Q Huang, F Zhang, H Bao, L Jia, ... Developmental cell 18 (1), 52-63, 2010 | 193 | 2010 |
| Genetic interaction mapping in mammalian cells using CRISPR interference D Du, A Roguev, DE Gordon, M Chen, SH Chen, M Shales, JP Shen, ... Nature methods 14 (6), 577-580, 2017 | 166 | 2017 |
| Tyrosine phosphorylated Par3 regulates epithelial tight junction assembly promoted by EGFR signaling Y Wang, D Du, L Fang, G Yang, C Zhang, R Zeng, A Ullrich, F Lottspeich, ... The EMBO journal 25 (21), 5058-5070, 2006 | 104 | 2006 |
| Aberrant splicing of Hugl-1 is associated with hepatocellular carcinoma progression X Lu, X Feng, X Man, G Yang, L Tang, D Du, F Zhang, H Yuan, Q Huang, ... Clinical cancer research 15 (10), 3287-3296, 2009 | 98 | 2009 |
| Innate antiviral host defense attenuates TGF-β function through IRF3-mediated suppression of Smad signaling P Xu, S Bailey-Bucktrout, Y Xi, D Xu, D Du, Q Zhang, W Xiang, J Liu, ... Molecular cell 56 (6), 723-737, 2014 | 80 | 2014 |
| Smad3‐mediated recruitment of the methyltransferase SETDB1/ESET controls Snail1 expression and epithelial–mesenchymal transition D Du, Y Katsuno, D Meyer, EH Budi, SH Chen, H Koeppen, H Wang, ... EMBO reports 19 (1), 135-155, 2018 | 67 | 2018 |
| Cell polarity protein Par3 complexes with DNA-PK via Ku70 and regulates DNA double-strand break repair L Fang, YG Wang, D Du, G Yang, T Tak Kwok, S Kai Kong, B Chen, ... Cell research 17 (2), 100-116, 2007 | 58 | 2007 |
| Efficiency comparison of apigenin-7-O-glucoside and trolox in antioxidative stress and anti-inflammatory properties W Wang, RF Yue, Z Jin, LM He, R Shen, D Du, YZ Tang Journal of Pharmacy and Pharmacology 72 (11), 1645-1656, 2020 | 44 | 2020 |
| Hepatocyte‐specific deletion of Cdc42 results in delayed liver regeneration after partial hepatectomy in mice H Yuan, H Zhang, X Wu, Z Zhang, D Du, W Zhou, S Zhou, C Brakebusch, ... Hepatology 49 (1), 240-249, 2009 | 41 | 2009 |
| Proteomic analysis reveals novel molecules involved in insulin signaling pathway Y Wang, R Li, D Du, C Zhang, H Yuan, R Zeng, Z Chen Journal of proteome research 5 (4), 846-855, 2006 | 41 | 2006 |
| CRISPR technology for genome activation and repression in mammalian cells D Du, LS Qi Cold Spring Harbor Protocols 2016 (1), pdb. prot090175, 2016 | 40* | 2016 |
| CRISPR technology for genome activation and repression in mammalian cells D Du, LS Qi Cold Spring Harbor Protocols 2016 (1), pdb. prot090175, 2016 | 40* | 2016 |
| Cdc42 is crucial for the maturation of primordial cell junctions in keratinocytes independent of Rac1 D Du, E Pedersen, Z Wang, R Karlsson, Z Chen, X Wu, C Brakebusch Experimental cell research 315 (8), 1480-1489, 2009 | 23 | 2009 |
| CRL4AMBRA1 targets Elongin C for ubiquitination and degradation to modulate CRL5 signaling SH Chen, GM Jang, R Hüttenhain, DE Gordon, D Du, BW Newton, ... The EMBO journal 37 (18), e97508, 2018 | 18 | 2018 |
| SNX14 deficiency-induced defective axonal mitochondrial transport in Purkinje cells underlies cerebellar ataxia and can be reversed by valproate H Zhang, Y Hong, W Yang, R Wang, T Yao, J Wang, K Liu, H Yuan, C Xu, ... National Science Review 8 (7), nwab024, 2021 | 15 | 2021 |
| Proteome identification of binding‐partners interacting with cell polarity protein Par3 in Jurkat cells Y Zhou, L Fang, D Du, W Zhou, X Feng, J Chen, Z Zhang, Z Chen Acta biochimica et biophysica Sinica 40 (8), 729-739, 2008 | 14 | 2008 |
| Design, synthesis and biological evaluation of novel pleuromutilin derivatives as potent anti-MRSA agents targeting the 50S ribosome SY Huang, X Wang, DY Shen, F Chen, GY Zhang, Z Zhang, K Li, Z Jin, ... Bioorganic & Medicinal Chemistry 38, 116138, 2021 | 10 | 2021 |
| Semisynthetic pleuromutilin antimicrobials with therapeutic potential against methicillin-resistant Staphylococcus aureus by targeting 50S ribosomal subunit X Wang, R Wang, ZS Zhang, GY Zhang, Z Jin, R Shen, D Du, YZ Tang European Journal of Medicinal Chemistry 237, 114341, 2022 | 8 | 2022 |
Si-Han ChenBristol Myers SquibbVerified email at bms.com
