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Ian Barrett
Ian Barrett
Senior Director, AstraZeneca
Verified email at astrazeneca.com
Title
Cited by
Cited by
Year
The DNA sequence of the human X chromosome
MT Ross, DV Grafham, AJ Coffey, S Scherer, K McLay, D Muzny, ...
Nature 434 (7031), 325-337, 2005
13812005
Drug screening in human PSC-cardiac organoids identifies pro-proliferative compounds acting via the mevalonate pathway
RJ Mills, BL Parker, GA Quaife-Ryan, HK Voges, EJ Needham, A Bornot, ...
Cell stem cell 24 (6), 895-907. e6, 2019
2352019
The brain-penetrant clinical ATM inhibitor AZD1390 radiosensitizes and improves survival of preclinical brain tumor models
ST Durant, L Zheng, Y Wang, K Chen, L Zhang, T Zhang, Z Yang, ...
Science advances 4 (6), eaat1719, 2018
2332018
A review of biomedical datasets relating to drug discovery: a knowledge graph perspective
S Bonner, IP Barrett, C Ye, R Swiers, O Engkvist, A Bender, CT Hoyt, ...
Briefings in Bioinformatics 23 (6), bbac404, 2022
752022
Orally bioavailable and blood–brain barrier-penetrating ATM inhibitor (AZ32) radiosensitizes intracranial gliomas in mice
J Karlin, J Allen, SF Ahmad, G Hughes, V Sheridan, R Odedra, ...
Molecular cancer therapeutics 17 (8), 1637-1647, 2018
552018
Understanding cytotoxicity and cytostaticity in a high-throughput screening collection
LH Mervin, Q Cao, IP Barrett, MA Firth, D Murray, L McWilliams, ...
ACS chemical biology 11 (11), 3007-3023, 2016
552016
Understanding the performance of knowledge graph embeddings in drug discovery
S Bonner, IP Barrett, C Ye, R Swiers, O Engkvist, CT Hoyt, WL Hamilton
Artificial Intelligence in the Life Sciences 2, 100036, 2022
462022
Orthologue chemical space and its influence on target prediction
LH Mervin, KC Bulusu, L Kalash, AM Afzal, F Svensson, MA Firth, I Barrett, ...
Bioinformatics 34 (1), 72-79, 2018
402018
Comparison of chemical structure and cell morphology information for multitask bioactivity predictions
MA Trapotsi, LH Mervin, AM Afzal, N Sturm, O Engkvist, IP Barrett, ...
Journal of chemical information and modeling 61 (3), 1444-1456, 2021
292021
A mathematical model of antibody-dependent cellular cytotoxicity (ADCC)
F Hoffman, D Gavaghan, J Osborne, IP Barrett, T You, H Ghadially, ...
Journal of Theoretical Biology 436, 39-50, 2018
282018
Cell morphological profiling enables high-throughput screening for PROteolysis TArgeting Chimera (PROTAC) phenotypic signature
MA Trapotsi, E Mouchet, G Williams, T Monteverde, K Juhani, R Turkki, ...
ACS Chemical Biology 17 (7), 1733-1744, 2022
262022
High-content phenotypic assay for proliferation of human iPSC-derived cardiomyocytes identifies L-type calcium channels as targets
LA Woo, S Tkachenko, M Ding, AT Plowright, O Engkvist, H Andersson, ...
Journal of molecular and cellular cardiology 127, 204-214, 2019
242019
Discovery of retinoic acid receptor agonists as proliferators of cardiac progenitor cells through a phenotypic screening approach
L Drowley, J McPheat, A Nordqvist, S Peel, U Karlsson, S Martinsson, ...
Stem cells translational medicine 9 (1), 47-60, 2020
222020
Signaling dynamics regulating crosstalks between T-cell activation and immune checkpoints
M Kreileder, I Barrett, C Bendtsen, D Brennan, W Kolch
Trends in cell biology 31 (3), 224-235, 2021
202021
Automatic extraction of angiogenesis bioprocess from text
X Wang, I McKendrick, I Barrett, I Dix, T French, J Tsujii, S Ananiadou
Bioinformatics 27 (19), 2730-2737, 2011
192011
Implications of topological imbalance for representation learning on biomedical knowledge graphs
S Bonner, U Kirik, O Engkvist, J Tang, IP Barrett
Briefings in Bioinformatics 23 (5), bbac279, 2022
142022
Probabilistic Random Forest improves bioactivity predictions close to the classification threshold by taking into account experimental uncertainty
LH Mervin, MA Trapotsi, AM Afzal, IP Barrett, A Bender, O Engkvist
Journal of Cheminformatics 13, 1-17, 2021
122021
The brain-penetrant clinical ATM inhibitor AZD1390 radiosensitizes and improves survival of preclinical brain tumor models. Sci Adv. 2018; 4 (6): eaat1719
ST Durant, L Zheng, Y Wang, K Chen, L Zhang, T Zhang, Z Yang, ...
Article PubMed PubMed Central CAS, 2022
102022
New associations between drug-induced adverse events in animal models and humans reveal novel candidate safety targets
KA Giblin, D Basili, AM Afzal, L Rosenbrier-Ribeiro, N Greene, I Barrett, ...
Chemical Research in Toxicology 34 (2), 438-451, 2020
102020
Cancer genome analysis informatics
IP Barrett
Genetic Variation: Methods and Protocols, 75-102, 2010
102010
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