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Jeff McKenna
Jeff McKenna
Bestätigte E-Mail-Adresse bei novartis.com
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Zitiert von
Zitiert von
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Harnessing the anti-cancer natural product nimbolide for targeted protein degradation
JN Spradlin, X Hu, CC Ward, SM Brittain, MD Jones, L Ou, M To, ...
Nature chemical biology 15 (7), 747-755, 2019
3052019
Magnitude of therapeutic STING activation determines CD8+ T cell-mediated anti-tumor immunity
KE Sivick, AL Desbien, LH Glickman, GL Reiner, L Corrales, NH Surh, ...
Cell reports 25 (11), 3074-3085. e5, 2018
3042018
Covalent ligand screening uncovers a RNF4 E3 ligase recruiter for targeted protein degradation applications
CC Ward, JI Kleinman, SM Brittain, PS Lee, CYS Chung, K Kim, Y Petri, ...
ACS chemical biology 14 (11), 2430-2440, 2019
2292019
The most common functional groups in bioactive molecules and how their popularity has evolved over time
P Ertl, E Altmann, JM McKenna
Journal of medicinal chemistry 63 (15), 8408-8418, 2020
1922020
Deubiquitinase-targeting chimeras for targeted protein stabilization
NJ Henning, L Boike, JN Spradlin, CC Ward, G Liu, E Zhang, BP Belcher, ...
Nature chemical biology 18 (4), 412-421, 2022
1502022
Asymmetric palladium-catalyzed directed intermolecular fluoroarylation of styrenes
EPA Talbot, TA Fernandes, JM McKenna, FD Toste
Journal of the American Chemical Society 136 (11), 4101-4104, 2014
1462014
The discovery of RPR 200765A, a p38 MAP kinase inhibitor displaying a good oral anti-arthritic efficacy
IM McLay, F Halley, JE Souness, J McKenna, V Benning, M Birrell, ...
Bioorganic & medicinal chemistry 9 (2), 537-554, 2001
1212001
Discovery of a covalent FEM1B recruiter for targeted protein degradation applications
NJ Henning, AG Manford, JN Spradlin, SM Brittain, E Zhang, JM McKenna, ...
Journal of the American Chemical Society 144 (2), 701-708, 2022
1062022
An algorithm-directed two-component library synthesized via solid-phase methodology yielding potent and orally bioavailable p38 MAP kinase inhibitors
JM McKenna, F Halley, JE Souness, IM McLay, SD Pickett, AJ Collis, ...
Journal of medicinal chemistry 45 (11), 2173-2184, 2002
1002002
Bardoxolone conjugation enables targeted protein degradation of BRD4
B Tong, M Luo, Y Xie, JN Spradlin, JA Tallarico, JM McKenna, M Schirle, ...
Scientific reports 10 (1), 15543, 2020
952020
Chemoproteomics-enabled discovery of covalent RNF114-based degraders that mimic natural product function
M Luo, JN Spradlin, L Boike, B Tong, SM Brittain, JM McKenna, ...
Cell chemical biology 28 (4), 559-566. e15, 2021
902021
Manumycin polyketides act as molecular glues between UBR7 and P53
Y Isobe, M Okumura, LM McGregor, SM Brittain, MD Jones, X Liang, ...
Nature chemical biology 16 (11), 1189-1198, 2020
872020
Discovery of a functional covalent ligand targeting an intrinsically disordered cysteine within MYC
L Boike, AG Cioffi, FC Majewski, NJ Henning, MD Jones, G Liu, ...
Cell chemical biology 28 (1), 4-13. e17, 2021
822021
A nimbolide-based kinase degrader preferentially degrades oncogenic BCR-ABL
B Tong, JN Spradlin, LFT Novaes, E Zhang, X Hu, M Moeller, SM Brittain, ...
ACS chemical biology 15 (7), 1788-1794, 2020
782020
The development and mechanistic investigation of a palladium-catalyzed 1, 3-arylfluorination of chromenes
RT Thornbury, V Saini, TA Fernandes, CB Santiago, EPA Talbot, ...
Chemical science 8 (4), 2890-2897, 2017
762017
Studies on the stereoselective synthesis of the marine antitumor agent eleutherobin
R Carter, K Hodgetts, J McKenna, P Magnus, S Wren
Tetrahedron 56 (26), 4367-4382, 2000
742000
Gold‐Catalyzed Redox Synthesis of Imidazo[1,2‐a]pyridines using Pyridine N‐Oxide and Alkynes
EPA Talbot, M Richardson, JM McKenna, FD Toste
Advanced synthesis & catalysis 356 (4), 687-691, 2014
732014
Heteroaryl compounds, compositions thereof, and methods of treatment therewith
DS Mortensen, MMD Mederos, JJ Sapienza, RJ Albers, SS Clareen, ...
US Patent 7,968,556, 2011
602011
Methods of treatment using heteroaryl compounds and compositions thereof
DS Mortensen, MMD Mederos, JJ Sapienza, RJ Albers, SS Clareen, ...
US Patent 8,383,634, 2013
472013
Chiral Diaryliodonium Phosphate Enables Light Driven Diastereoselective α-C(sp3)–H Acetalization
B Ye, J Zhao, K Zhao, JM McKenna, FD Toste
Journal of the American Chemical Society 140 (26), 8350-8356, 2018
442018
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