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Dietrich Keppler
Dietrich Keppler
Professor Emeritus Heidelberg University and German Cancer Research Center
Bestätigte E-Mail-Adresse bei kabelbw.de
Titel
Zitiert von
Zitiert von
Jahr
Membrane transporters in drug development
KM Giacomini, SM Huang, DJ Tweedie, LZ Benet, KLR Brouwer, X Chu, ...
Nature Reviews Drug Discovery 9 (3), 215-236, 2010
3481*2010
The MRP gene encodes an ATP-dependent export pump for leukotriene C4 and structurally related conjugates.
I Leier, G Jedlitschky, U Buchholz, SPC Cole, RG Deeley, D Keppler
Journal of Biological Chemistry 269 (45), 27807-27810, 1994
10781994
Conjugate export pumps of the multidrug resistance protein (MRP) family: localization, substrate specificity, and MRP2-mediated drug resistance
J König, AT Nies, Y Cui, I Leier, D Keppler
Biochimica et Biophysica Acta (BBA)-Biomembranes 1461 (2), 377-394, 1999
9881999
Glycogen determination with amyloglucosidase
D Keppler, K Decker
Methods of Enzymatic Analysis (Bergmeyer, HU, editor) 4, 1127-1131, 1974
948*1974
Drug resistance and ATP-dependent conjugate transport mediated by the apical multidrug resistance protein, MRP2, permanently expressed in human and canine cells
Y Cui, J König, U Buchholz, H Spring, I Leier, D Keppler
Molecular Pharmacology 55 (5), 929-937, 1999
8781999
cDNA cloning of the hepatocyte canalicular isoform of the multidrug resistance protein, cMrp, reveals a novel conjugate export pump deficient in hyperbilirubinemic mutant rats
M Büchler, J König, M Brom, J Kartenbeck, H Spring, T Horie, D Keppler
Journal of Biological Chemistry 271 (25), 15091-15098, 1996
8011996
Transport of glutathione, glucuronate, and sulfate conjugates by the MRP gene-encoded conjugate export pump
G Jedlitschky, I Leier, U Buchholz, K Barnouin, G Kurz, D Keppler
Cancer Research 56 (5), 988-994, 1996
7651996
A novel human organic anion transporting polypeptide localized to the basolateral hepatocyte membrane
J König, Y Cui, AT Nies, D Keppler
American Journal of Physiology-Gastrointestinal and Liver Physiology 278 (1 …, 2000
7632000
Experimental hepatitis induced by D-galactosamine
D Keppler, R Lesch, W Reutter, K Decker
Experimental and Molecular Pathology 9 (2), 279-290, 1968
7501968
Localization and genomic organization of a new hepatocellular organic anion transporting polypeptide
J König, Y Cui, AT Nies, D Keppler
Journal of Biological Chemistry 275 (30), 23161-23168, 2000
6412000
Hepatic uptake of bilirubin and its conjugates by the human organic anion transporter SLC21A6
Y Cui, J König, I Leier, U Buchholz, D Keppler
Journal of Biological Chemistry 276 (13), 9626-9630, 2001
6262001
Characterization of the human multidrug resistance protein isoform MRP3 localized to the basolateral hepatocyte membrane
J König, D Rost, Y Cui, D Keppler
Hepatology 29 (4), 1156-1163, 1999
6081999
The rat canalicular conjugate export pump (Mrp2) is down-regulated in intrahepatic and obstructive cholestasis
M Trauner, M Arrese, CJ Soroka, M Ananthanarayanan, TA Koeppel, ...
Gastroenterology 113 (1), 255-264, 1997
5871997
The multidrug resistance protein 5 functions as an ATP-dependent export pump for cyclic nucleotides
G Jedlitschky, B Burchell, D Keppler
Journal of Biological Chemistry 275 (39), 30069-30074, 2000
5712000
Galactosamine hepatitis: key role of the nucleotide deficiency period in the pathogenesis of cell injury and cell death
K Decker, D Keppler
Reviews of Physiology, Biochemistry and Pharmacology, Volume 71, 77-106, 1974
570*1974
ATP-dependent Transport of Glutathione S-Conjugates by the Multidrug Resistance-associated Protein
G Jedlitschky, I Leier, U Buchholz, M Center, D Keppler
Cancer Research 54 (18), 4833-4836, 1994
5551994
Absence of the canalicular isoform of the MRP gene–encoded conjugate export pump from the hepatocytes in Dubin‐Johnson syndrome
J Kartenbeck, U Leuschner, R Mayer, D Keppler
Hepatology 23 (5), 1061-1066, 1996
5111996
Expression and immunolocalization of the multidrug resistance proteins, MRP1–MRP6 (ABCC1–ABCC6), in human brain
AT Nies, G Jedlitschky, J König, C Herold-Mende, HH Steiner, HP Schmitt, ...
Neuroscience 129 (2), 349-360, 2004
4712004
The apical conjugate efflux pump ABCC2 (MRP2)
AT Nies, D Keppler
Pflügers Archiv-European Journal of Physiology 453, 643-659, 2007
4692007
Cotransport of reduced glutathione with bile salts by MRP4 (ABCC4) localized to the basolateral hepatocyte membrane
M Rius, AT Nies, J Hummel‐Eisenbeiss, G Jedlitschky, D Keppler
Hepatology 38 (2), 374-384, 2003
4432003
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