Indolocarbazole natural products: occurrence, biosynthesis, and biological activity C Sánchez, C Méndez, JA Salas Natural product reports 23 (6), 1007-1045, 2006 | 455 | 2006 |
The biosynthetic gene cluster for the antitumor drug bleomycin from Streptomyces verticillus ATCC15003 supporting functional interactions between nonribosomal peptide … L Du, C Sánchez, M Chen, DJ Edwards, B Shen Chemistry & biology 7 (8), 623-642, 2000 | 380 | 2000 |
Hybrid peptide–polyketide natural products: Biosynthesis and prospects toward engineering novel molecules L Du, C Sánchez, B Shen Metabolic engineering 3 (1), 78-95, 2001 | 298 | 2001 |
Combinatorial biosynthesis of antitumor indolocarbazole compounds C Sánchez, L Zhu, AF Braña, AP Salas, J Rohr, C Méndez, JA Salas Proceedings of the National Academy of Sciences 102 (2), 461-466, 2005 | 295 | 2005 |
The Biosynthetic Gene Cluster for the Antitumor Rebeccamycin:: Characterization and Generation of Indolocarbazole Derivatives C Sánchez, IA Butovich, AF Braña, J Rohr, C Méndez, JA Salas Chemistry & biology 9 (4), 519-531, 2002 | 264 | 2002 |
Cloning and characterization of a phosphopantetheinyl transferase from Streptomyces verticillus ATCC15003, the producer of the hybrid peptide–polyketide antitumor drug bleomycin C Sánchez, L Du, DJ Edwards, MD Toney, B Shen Chemistry & biology 8 (7), 725-738, 2001 | 215 | 2001 |
Biosynthesis of the angiogenesis inhibitor borrelidin by Streptomyces parvulus Tü4055: cluster analysis and assignment of functions C Olano, B Wilkinson, C Sánchez, SJ Moss, R Sheridan, V Math, ... Chemistry & biology 11 (1), 87-97, 2004 | 203 | 2004 |
Reevaluation of the violacein biosynthetic pathway and its relationship to indolocarbazole biosynthesis C Sánchez, AF Braña, C Méndez, JA Salas ChemBioChem 7 (8), 1231-1240, 2006 | 163 | 2006 |
Deciphering the late steps in the biosynthesis of the anti‐tumour indolocarbazole staurosporine: sugar donor substrate flexibility of the StaG glycosyltransferase AP Salas, L Zhu, C Sánchez, AF Braña, J Rohr, C Méndez, JA Salas Molecular microbiology 58 (1), 17-27, 2005 | 153 | 2005 |
Cloning and Characterization of the Bleomycin Biosynthetic Gene Cluster from Streptomyces verticillus ATCC15003 B Shen, L Du, C Sanchez, DJ Edwards, M Chen, JM Murrell Journal of natural products 65 (3), 422-431, 2002 | 109 | 2002 |
The biosynthetic gene cluster for the anticancer drug bleomycin from Streptomyces verticillus ATCC15003 as a model for hybrid peptide–polyketide natural product biosynthesis B Shen, L Du, C Sanchez, DJ Edwards, M Chen, JM Murrell Journal of Industrial Microbiology and Biotechnology 27 (6), 378-385, 2001 | 104 | 2001 |
An oxidation domain in the BlmIII non‐ribosomal peptide synthetase probably catalyzing thiazole formation in the biosynthesis of the anti‐tumor drug bleomycin in Streptomyces … L Du, M Chen, C Sánchez, B Shen FEMS microbiology letters 189 (2), 171-175, 2000 | 91 | 2000 |
Characterization of two polyketide methyltransferases involved in the biosynthesis of the antitumor drug mithramycin byStreptomyces argillaceus MJF Lozano, LL Remsing, LM Quirós, AF Braña, E Fernández, C Sánchez, ... Journal of Biological Chemistry 275 (5), 3065-3074, 2000 | 90 | 2000 |
2. Biochemical Engineering of Natural Product Biosynthesis Pathways WR Strohl, Y Xue, DH Sherman, R Barkovich, JC Liao, H Liu, ... Metabolic Engineering 3 (1), 1-95, 2001 | 78 | 2001 |
Generation of potent and selective kinase inhibitors by combinatorial biosynthesis of glycosylated indolocarbazoles C Sánchez, AP Salas, AF Braña, M Palomino, A Pineda-Lucena, ... Chemical Communications, 4118-4120, 2009 | 70 | 2009 |
Engineering biosynthetic pathways to generate antitumor indolocarbazole derivatives C Sánchez, C Méndez, JA Salas Journal of Industrial Microbiology and Biotechnology 33 (7), 560-568, 2006 | 62 | 2006 |
Bleomycin Biosynthesis in< i> Streptomyces verticillus</i> ATCC15003: A Model of Hybrid Peptide and Polyketide Biosynthesis B Shen, L Du, C Sanchez, M Chen, DJ Edwards Bioorganic Chemistry 27 (2), 155-171, 1999 | 52 | 1999 |
Prerequisites for combinatorial biosynthesis: evolution of hybrid NRPS/PKS gene clusters B Shen, M Chen, Y Cheng, L Du, DJ Edwards, NP George, Y Huang, T Oh, ... Biocombinatorial Approaches for Drug Finding, 107-126, 2005 | 9 | 2005 |
Bacterial evolution: Phage resistance comes at a cost C Sanchez Nature Reviews Microbiology 9 (6), 398-399, 2011 | 8 | 2011 |
Cellular microbiology: Bacterial networking C Sanchez Nature Reviews Microbiology 9 (4), 229-229, 2011 | 8 | 2011 |