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Lena Marie Berger
Lena Marie Berger
Bestätigte E-Mail-Adresse bei pharmchem.uni-frankfurt.de - Startseite
Titel
Zitiert von
Zitiert von
Jahr
Design, synthesis, and evaluation of WD-repeat-containing protein 5 (WDR5) degraders
A Dölle, B Adhikari, A Krämer, J Weckesser, N Berner, LM Berger, ...
Journal of medicinal chemistry 64 (15), 10682-10710, 2021
412021
Structure-based design of selective salt-inducible kinase inhibitors
R Tesch, M Rak, M Raab, LM Berger, T Kronenberger, AC Joerger, ...
Journal of Medicinal Chemistry 64 (12), 8142-8160, 2021
242021
Inhibitors of the Hippo pathway kinases STK3/MST2 and STK4/MST1 have utility for the treatment of acute myeloid leukemia
N Bata, A Chaikuad, NA Bakas, AS Limpert, LJ Lambert, DJ Sheffler, ...
Journal of medicinal chemistry 65 (2), 1352-1369, 2021
172021
Design of a “two-in-one” mutant-selective epidermal growth factor receptor inhibitor that spans the orthosteric and allosteric sites
F Wittlinger, DE Heppner, C To, M Günther, BH Shin, JK Rana, ...
Journal of medicinal chemistry 65 (2), 1370-1383, 2021
172021
A highly selective chemical probe for activin receptor-like kinases ALK4 and ALK5
T Hanke, JF Wong, BT Berger, I Abdi, LM Berger, R Tesch, C Tredup, ...
ACS Chemical Biology 15 (4), 862-870, 2020
142020
Solution structures and biophysical analysis of full-length group A PAKs reveal they are monomeric and auto-inhibited in cis
FJ Sorrell, LM Kilian, JM Elkins
Biochemical Journal 476 (7), 1037-1051, 2019
132019
Illuminating the Dark: Highly Selective Inhibition of Serine/Threonine Kinase 17A with Pyrazolo[1,5-a]pyrimidine-Based Macrocycles
CG Kurz, F Preuss, A Tjaden, M Cusack, JA Amrhein, D Chatterjee, ...
Journal of Medicinal Chemistry 65 (11), 7799-7817, 2022
102022
A Toolbox for the Generation of Chemical Probes for Baculovirus IAP Repeat Containing Proteins
MP Schwalm, LM Berger, MN Meuter, JD Vasta, CR Corona, S Röhm, ...
Frontiers in Cell and Developmental Biology 10, 886537, 2022
82022
Single tracer-based protocol for broad-spectrum kinase profiling in live cells with NanoBRET
MB Robers, JM Wilkinson, JD Vasta, LM Berger, BT Berger, S Knapp
STAR protocols 2 (4), 100822, 2021
82021
Pharmacokinetic Optimization of Small Molecule Janus Kinase 3 Inhibitors to Target Immune Cells
J Laux, M Forster, L Riexinger, A Schwamborn, J Guezguez, C Pokoj, ...
ACS Pharmacology & Translational Science 5 (8), 573-602, 2022
52022
Shifting the selectivity of pyrido [2, 3-d] pyrimidin-7 (8H)-one inhibitors towards the salt-inducible kinase (SIK) subfamily
M Rak, R Tesch, LM Berger, E Shevchenko, M Raab, A Tjaden, R Zhubi, ...
European Journal of Medicinal Chemistry 254, 115347, 2023
42023
Design and Synthesis of Pyrazole-Based Macrocyclic Kinase Inhibitors Targeting BMPR2
JA Amrhein, G Wang, BT Berger, LM Berger, AD Kalampaliki, A Krämer, ...
ACS Medicinal Chemistry Letters, 2023
42023
Discovery of 3-Amino-1H-pyrazole-Based Kinase Inhibitors to Illuminate the Understudied PCTAIRE Family
JA Amrhein, LM Berger, A Tjaden, A Krämer, L Elson, T Tolvanen, ...
International Journal of Molecular Sciences 23 (23), 14834, 2022
32022
C81‐evoked inhibition of the TNFR1‐NFκB pathway during inflammatory processes for stabilization of the impaired vascular endothelial barrier for leukocytes
GM Krishnathas, B Strödke, L Mittmann, T Zech, LM Berger, CA Reichel, ...
The FASEB Journal 35 (6), e21656, 2021
32021
Development of potent dual BET/HDAC inhibitors via pharmacophore merging and structure-guided optimization
N Bauer, DI Balourdas, JR Schneider, X Zhang, LM Berger, BT Berger, ...
ACS Chemical Biology, 2024
12024
Back-pocket optimization of 2-aminopyrimidine-based macrocycles leads to potent dual EPHA2/GAK kinase inhibitors with antiviral activity
J Gerninghaus, R Zhubi, A Kraemer, M Karim, DHN Tran, AC Joerger, ...
bioRxiv, 2024.02. 18.580805, 2024
2024
Synthesis of pyrazole-based macrocycles leads to a highly selective inhibitor for MST3
JA Amrhein, LM Berger, DI Balourdas, AC Joerger, A Menge, A Krämer, ...
Journal of Medicinal Chemistry 67 (1), 674-690, 2023
2023
Deep Annotation of Donated Chemical Probes (DCP) in Organotypic Human Liver Cultures and Patient-Derived Organoids from Tumor and Normal Colorectum
C Tredup, B Ndreshkjana, NS Schneider, A Tjaden, AM Kemas, ...
ACS Chemical Biology 18 (4), 822-836, 2023
2023
Development of selective pyrido [2, 3-d] pyrimidin-7 (8H)-one-based Mammalian STE20-like (MST3/4) kinase inhibitors
M Rak, A Menge, R Tesch, LM Berger, DI Balourdas, E Shevchenko, ...
bioRxiv, 2023.11. 24.568596, 2023
2023
Cellular selectivity and kinetics of clinical kinase inhibitors
LM Berger
Universitätsbibliothek Johann Christian Senckenberg, 2023
2023
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