|PDX-1 is required for pancreatic outgrowth and differentiation of the rostral duodenum|
MF Offield, TL Jetton, PA Labosky, M Ray, RW Stein, MA Magnuson, ...
Development 122 (3), 983-995, 1996
|Loss of insulin signaling in hepatocytes leads to severe insulin resistance and progressive hepatic dysfunction|
MD Michael, RN Kulkarni, C Postic, SF Previs, GI Shulman, ...
Molecular cell 6 (1), 87-97, 2000
|Tissue-specific knockout of the insulin receptor in pancreatic β cells creates an insulin secretory defect similar to that in type 2 diabetes|
RN Kulkarni, JC Brüning, JN Winnay, C Postic, MA Magnuson, CR Kahn
Cell 96 (3), 329-339, 1999
|Dual roles for glucokinase in glucose homeostasis as determined by liver and pancreatic β cell-specific gene knock-outs using Cre recombinase|
C Postic, M Shiota, KD Niswender, TL Jetton, Y Chen, JM Moates, ...
Journal of Biological Chemistry 274 (1), 305-315, 1999
|Thiazolidinediones expand body fluid volume through PPARγ stimulation of ENaC-mediated renal salt absorption|
YF Guan, C Hao, DR Cha, R Rao, W Lu, DE Kohan, MA Magnuson, ...
Nature medicine 11 (8), 861-866, 2005
|Allosteric activators of glucokinase: potential role in diabetes therapy|
J Grimsby, R Sarabu, WL Corbett, NE Haynes, FT Bizzarro, JW Coffey, ...
Science 301 (5631), 370-373, 2003
|Deletion of PPARγ in adipose tissues of mice protects against high fat diet-induced obesity and insulin resistance|
JR Jones, C Barrick, KA Kim, J Lindner, B Blondeau, Y Fujimoto, M Shiota, ...
Proceedings of the National Academy of Sciences 102 (17), 6207-6212, 2005
|Identification of Protor as a novel Rictor-binding component of mTOR complex-2|
LR Pearce, X Huang, J Boudeau, R Pawłowski, S Wullschleger, M Deak, ...
Biochemical Journal 405 (3), 513-522, 2007
|Neonatal diabetes mellitus due to complete glucokinase deficiency|
PR Njølstad, O Søvik, A Cuesta-Muñoz, L Bjørkhaug, O Massa, F Barbetti, ...
New England Journal of Medicine 344 (21), 1588-1592, 2001
|Hepatic glucokinase is required for the synergistic action of ChREBP and SREBP-1c on glycolytic and lipogenic gene expression|
R Dentin, JP Pégorier, F Benhamed, F Foufelle, P Ferré, V Fauveau, ...
Journal of Biological Chemistry 279 (19), 20314-20326, 2004
|Multiallelic disruption of the rictor gene in mice reveals that mTOR complex 2 is essential for fetal growth and viability|
C Shiota, JT Woo, J Lindner, KD Shelton, MA Magnuson
Developmental cell 11 (4), 583-589, 2006
|mTOR complex 2 is required for the development of prostate cancer induced by Pten loss in mice|
DA Guertin, DM Stevens, M Saitoh, S Kinkel, K Crosby, JH Sheen, ...
Cancer cell 15 (2), 148-159, 2009
|Impaired insulin secretion and β-cell loss in tissue-specific knockout mice with mitochondrial diabetes|
JP Silva, M Köhler, C Graff, A Oldfors, MA Magnuson, PO Berggren, ...
Nature genetics 26 (3), 336-340, 2000
|Salt–sensitive hypertension and reduced fertility in mice lacking the prostaglandin EP 2 receptor|
CRJ Kennedy, Y Zhang, S Brandon, Y Guan, K Coffee, CD Funk, ...
Nature medicine 5 (2), 217-220, 1999
|Liver-specific deletion of negative regulator Pten results in fatty liver and insulin hypersensitivity|
B Stiles, Y Wang, A Stahl, S Bassilian, WP Lee, YJ Kim, R Sherwin, ...
Proceedings of the National Academy of Sciences 101 (7), 2082-2087, 2004
|Mammalian target of rapamycin protein complex 2 regulates differentiation of Th1 and Th2 cell subsets via distinct signaling pathways|
K Lee, P Gudapati, S Dragovic, C Spencer, S Joyce, N Killeen, ...
Immunity 32 (6), 743-753, 2010
|β-cell–specific deletion of the Igf1 receptor leads to hyperinsulinemia and glucose intolerance but does not alter β-cell mass|
RN Kulkarni, M Holzenberger, DQ Shih, U Ozcan, M Stoffel, ...
Nature genetics 31 (1), 111-115, 2002
|Pancreatic beta-cell glucokinase: closing the gap between theoretical concepts and experimental realities.|
FM Matschinsky, B Glaser, MA Magnuson
Diabetes 47 (3), 307-315, 1998
|DNA excision in liver by an albumin‐Cre transgene occurs progressively with age|
C Postic, MA Magnuson
genesis 26 (2), 149-150, 2000
|Dopamine biosynthesis is selectively abolished in substantia nigra/ventral tegmental area but not in hypothalamic neurons in mice with targeted disruption of the Nurr1 gene|
SO Castillo, JS Baffi, M Palkovits, DS Goldstein, IJ Kopin, J Witta, ...
Molecular and Cellular Neuroscience 11 (1-2), 36-46, 1998