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James D. Ormes
James D. Ormes
Bestätigte E-Mail-Adresse bei merck.com
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Impact of surfactants on the crystallization of aqueous suspensions of celecoxib amorphous solid dispersion spray dried particles
J Chen, JD Ormes, JD Higgins, LS Taylor
Molecular pharmaceutics 12 (2), 533-541, 2015
1442015
Discovery of Vibegron: A Potent and Selective β3 Adrenergic Receptor Agonist for the Treatment of Overactive Bladder
SD Edmondson, C Zhu, NF Kar, J Di Salvo, H Nagabukuro, ...
Journal of Medicinal Chemistry 59 (2), 609-623, 2016
1032016
Bile salts as crystallization inhibitors of supersaturated solutions of poorly water-soluble compounds
J Chen, LI Mosquera-Giraldo, JD Ormes, JD Higgins, LS Taylor
Crystal Growth & Design 15 (6), 2593-2597, 2015
872015
Insights into nano-and micron-scale phase separation in amorphous solid dispersions using fluorescence-based techniques in combination with solid state nuclear magnetic …
HS Purohit, JD Ormes, S Saboo, Y Su, MS Lamm, AKP Mann, LS Taylor
Pharmaceutical research 34, 1364-1377, 2017
652017
A comparison of the crystallization inhibition properties of bile salts
N Li, LI Mosquera-Giraldo, CH Borca, JD Ormes, M Lowinger, JD Higgins, ...
Crystal Growth & Design 16 (12), 7286-7300, 2016
582016
Drug release and nanodroplet formation from amorphous solid dispersions: insight into the roles of drug physicochemical properties and polymer selection
R Yang, AKP Mann, T Van Duong, JD Ormes, GA Okoh, A Hermans, ...
Molecular pharmaceutics 18 (5), 2066-2081, 2021
502021
Maintaining supersaturation of active pharmaceutical ingredient solutions with biologically relevant bile salts
J Lu, JD Ormes, M Lowinger, AKP Mann, W Xu, JD Litster, LS Taylor
Crystal Growth & Design 17 (5), 2782-2791, 2017
392017
Impact of endogenous bile salts on the thermodynamics of supersaturated active pharmaceutical ingredient solutions
J Lu, JD Ormes, M Lowinger, W Xu, A Mitra, AKP Mann, JD Litster, ...
Crystal Growth & Design 17 (3), 1264-1275, 2017
362017
Impact of bile salts on solution crystal growth rate and residual supersaturation of an active pharmaceutical ingredient
J Lu, JD Ormes, M Lowinger, AKP Mann, W Xu, S Patel, JD Litster, ...
Crystal Growth & Design 17 (6), 3528-3537, 2017
332017
Design of experiments utilization to map the processing capabilities of a micro-spray dryer: particle design and throughput optimization in support of drug discovery
JD Ormes, D Zhang, AM Chen, S Hou, D Krueger, T Nelson, A Templeton
Pharmaceutical Development and Technology 18 (1), 121-129, 2013
322013
Compositional effect of complex biorelevant media on the crystallization kinetics of an active pharmaceutical ingredient
J Lu, JD Ormes, M Lowinger, AKP Mann, W Xu, S Patel, JD Litster, ...
CrystEngComm 19 (32), 4797-4806, 2017
182017
In situ analytical characterization and chemical imaging of tablet coatings using laser induced breakdown spectroscopy (LIBS)
L Zou, B Kassim, JP Smith, JD Ormes, Y Liu, Q Tu, X Bu
Analyst 143 (20), 5000-5007, 2018
162018
The renal outer medullary potassium channel inhibitor, MK-7145, lowers blood pressure, and manifests features of Bartter’s syndrome Type II phenotype
C Hampton, X Zhou, BT Priest, LY Pai, JP Felix, B Thomas-Fowlkes, J Liu, ...
Journal of Pharmacology and Experimental Therapeutics 359 (1), 194-206, 2016
162016
Leaching of lopinavir amorphous solid dispersions in acidic media
N Li, JD Ormes, LS Taylor
Pharmaceutical research 33, 1723-1735, 2016
142016
Effect of drug incorporation and polymer properties on the characteristics of electrospun nanofibers for drug delivery
MB Gelb, A Punia, S Sellers, P Kadakia, JD Ormes, NN Khawaja, J Wylie, ...
Journal of Drug Delivery Science and Technology 68, 103112, 2022
122022
How broadly can poly (urethane)-based implants be applied to drugs of varied properties?
MB Lowinger, JD Ormes, Y Su, JH Small, RO Williams III, F Zhang
International Journal of Pharmaceutics 568, 118550, 2019
92019
Direct visualization of drug release in injectable implant by laser induced breakdown spectroscopy (LIBS)
L Zou, MJ Stenslik, MB Giles, JD Ormes, M Marsales, C Santos, B Kassim, ...
Journal of Analytical Atomic Spectrometry 34 (7), 1351-1354, 2019
92019
Solubility and dissolution considerations for amorphous solid dispersions
GA Ilevbare, W Xu, CT John, JD Ormes, JL Kuiper, AC Templeton, A Bak
Pharmaceutical Amorphous Solid Dispersions, 218, 2015
82015
High bulk-density amorphous dispersions to enable direct compression of reduced tablet size amorphous dosage units
DS Frank, H Nie, A Chandra, A Coelho, C Dalton, H Dvorak, A Elkhabaz, ...
Journal of Pharmaceutical Sciences 112 (8), 2037-2045, 2023
62023
Improved stability of proline-derived direct thrombin inhibitors through hydroxyl to heterocycle replacement
HR Chobanian, B Pio, Y Guo, H Shen, MA Huffman, M Madeira, ...
ACS Medicinal Chemistry Letters 6 (5), 553-557, 2015
52015
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