| NLRX1 is a regulator of mitochondrial antiviral immunity CB Moore, DT Bergstralh, JA Duncan, Y Lei, TE Morrison, ... Nature 451 (7178), 573-577, 2008 | 662 | 2008 |
| RIP3 induces apoptosis independent of pronecrotic kinase activity P Mandal, SB Berger, S Pillay, K Moriwaki, C Huang, H Guo, JD Lich, ... Molecular cell 56 (4), 481-495, 2014 | 567 | 2014 |
| NLRP12 suppresses colon inflammation and tumorigenesis through the negative regulation of noncanonical NF-κB signaling IC Allen, JE Wilson, M Schneider, JD Lich, RA Roberts, JC Arthur, ... Immunity 36 (5), 742-754, 2012 | 536 | 2012 |
| Discovery of a first-in-class receptor interacting protein 1 (RIP1) kinase specific clinical candidate (GSK2982772) for the treatment of inflammatory diseases PA Harris, SB Berger, JU Jeong, R Nagilla, D Bandyopadhyay, ... Journal of medicinal chemistry 60 (4), 1247-1261, 2017 | 416 | 2017 |
| Autolytic proteolysis within the function to find domain (FIIND) is required for NLRP1 inflammasome activity JN Finger, JD Lich, LC Dare, MN Cook, KK Brown, C Duraiswami, ... Journal of Biological Chemistry 287 (30), 25030-25037, 2012 | 280 | 2012 |
| Cutting edge: Monarch-1 suppresses non-canonical NF-κB activation and p52-dependent chemokine expression in monocytes JD Lich, KL Williams, CB Moore, JC Arthur, BK Davis, DJ Taxman, ... The Journal of Immunology 178 (3), 1256-1260, 2007 | 241 | 2007 |
| The CATERPILLER protein Monarch-1 is an antagonist of Toll-like receptor-, tumor necrosis factor α-, and Mycobacterium tuberculosis-induced pro-inflammatory signals KL Williams, JD Lich, JA Duncan, W Reed, P Rallabhandi, C Moore, ... Journal of Biological Chemistry 280 (48), 39914-39924, 2005 | 240 | 2005 |
| Proteomic profiling drug-induced apoptosis in non-small cell lung carcinoma: identification of RS/DJ-1 and RhoGDIα JP MacKeigan, CM Clements, JD Lich, RM Pope, Y Hod, JPY Ting Cancer research 63 (20), 6928-6934, 2003 | 229 | 2003 |
| RIP1 kinase drives macrophage-mediated adaptive immune tolerance in pancreatic cancer W Wang, JM Marinis, AM Beal, S Savadkar, Y Wu, M Khan, PS Taunk, ... Cancer cell 34 (5), 757-774. e7, 2018 | 189 | 2018 |
| Cytoplasmic processing is a prerequisite for presentation of an endogenous antigen by major histocompatibility complex class II proteins JD Lich, JF Elliott, JS Blum The Journal of experimental medicine 191 (9), 1513-1524, 2000 | 183 | 2000 |
| Criteria for effective design, construction, and gene knockdown by shRNA vectors DJ Taxman, LR Livingstone, J Zhang, BJ Conti, HA Iocca, KL Williams, ... BMC biotechnology 6, 1-16, 2006 | 173 | 2006 |
| Cutting edge: NLRP12 controls dendritic and myeloid cell migration to affect contact hypersensitivity JC Arthur, JD Lich, Z Ye, IC Allen, D Gris, JE Wilson, M Schneider, ... The Journal of Immunology 185 (8), 4515-4519, 2010 | 162 | 2010 |
| Discovery of small molecule RIP1 kinase inhibitors for the treatment of pathologies associated with necroptosis PA Harris, D Bandyopadhyay, SB Berger, N Campobasso, CA Capriotti, ... ACS medicinal chemistry letters 4 (12), 1238-1243, 2013 | 148 | 2013 |
| ATP binding by monarch-1/NLRP12 is critical for its inhibitory function Z Ye, JD Lich, CB Moore, JA Duncan, KL Williams, JPY Ting Molecular and cellular biology 28 (5), 1841-1850, 2008 | 129 | 2008 |
| Randomized clinical study of safety, pharmacokinetics, and pharmacodynamics of RIPK 1 inhibitor GSK 2982772 in healthy volunteers K Weisel, NE Scott, DJ Tompson, BJ Votta, S Madhavan, K Povey, ... Pharmacology research & perspectives 5 (6), e00365, 2017 | 111 | 2017 |
| Cutting edge: ASC mediates the induction of multiple cytokines by Porphyromonas gingivalis via caspase-1-dependent and-independent pathways DJ Taxman, J Zhang, C Champagne, DT Bergstralh, HA Iocca, JD Lich, ... The Journal of Immunology 177 (7), 4252-4256, 2006 | 85 | 2006 |
| Heat shock protein 90 associates with monarch-1 and regulates its ability to promote degradation of NF-κB-inducing kinase JC Arthur, JD Lich, RK Aziz, M Kotb, JPY Ting The Journal of Immunology 179 (9), 6291-6296, 2007 | 78 | 2007 |
| Characterization of NLRP12 during the in vivo host immune response to Klebsiella pneumoniae and Mycobacterium tuberculosis IC Allen, E McElvania-TeKippe, JE Wilson, JD Lich, JC Arthur, JT Sullivan, ... PloS one 8 (4), e60842, 2013 | 71 | 2013 |
| Semaphorin 6D regulates the late phase of CD4+ T cell primary immune responses BP O'Connor, SY Eun, Z Ye, AL Zozulya, JD Lich, CB Moore, HA Iocca, ... Proceedings of the National Academy of Sciences 105 (35), 13015-13020, 2008 | 69 | 2008 |
| Identification of a RIP1 kinase inhibitor clinical candidate (GSK3145095) for the treatment of pancreatic cancer PA Harris, JM Marinis, JD Lich, SB Berger, A Chirala, JA Cox, PM Eidam, ... ACS medicinal chemistry letters 10 (6), 857-862, 2019 | 65 | 2019 |
