New Tacrine–4-Oxo-4H-chromene Hybrids as Multifunctional Agents for the Treatment of Alzheimer’s Disease, with Cholinergic, Antioxidant, and β-Amyloid … MI Fernández-Bachiller, C Pérez, L Monjas, J Rademann, ... Journal of medicinal chemistry 55 (3), 1303-1317, 2012 | 312 | 2012 |
Lysosomal pathology and osteopetrosis upon loss of H+-driven lysosomal Cl–accumulation S Weinert, S Jabs, C Supanchart, M Schweizer, N Gimber, M Richter, ... Science 328 (5984), 1401-1403, 2010 | 263 | 2010 |
Specific inhibitors of the protein tyrosine phosphatase Shp2 identified by high-throughput docking K Hellmuth, S Grosskopf, CT Lum, M Würtele, N Röder, JP von Kries, ... Proceedings of the National Academy of Sciences 105 (20), 7275-7280, 2008 | 246 | 2008 |
Oxidizing polymers: a polymer-supported, recyclable hypervalent iodine (V) reagent for the efficient conversion of alcohols, carbonyl compounds, and unsaturated carbamates in … G Sorg, A Mengel, G Jung, J Rademann Angewandte Chemie (International ed. in English) 40 (23), 4395-4397, 2001 | 198 | 2001 |
SPOCC: A resin for solid-phase organic chemistry and enzymatic reactions on solid phase J Rademann, M Grøtli, M Meldal, K Bock Journal of the American Chemical Society 121 (23), 5459-5466, 1999 | 196 | 1999 |
Hyaluronan/collagen hydrogels containing sulfated hyaluronan improve wound healing by sustained release of heparin-binding EGF-like growth factor S Thönes, S Rother, T Wippold, J Blaszkiewicz, K Balamurugan, ... Acta biomaterialia 86, 135-147, 2019 | 148 | 2019 |
Peptide aldehyde inhibitors challenge the substrate specificity of the SARS-coronavirus main protease L Zhu, S George, MF Schmidt, SI Al-Gharabli, J Rademann, R Hilgenfeld Antiviral research 92 (2), 204-212, 2011 | 139 | 2011 |
Repetitive solid phase glycosylation on an alkyl thiol polymer leading to sugar oligomers containing 1, 2-trans-and 1, 2-cis-glycosidic linkages J Rademann, RR Schmidt The Journal of Organic Chemistry 62 (11), 3650-3653, 1997 | 136 | 1997 |
Endotoxin-like properties of a rhamnolipid exotoxin from Burkholderia (Pseudomonas) plantarii: immune cell stimulation and biophysical characterization J Andrä, J Rademann, J Howe, MHJ Koch, H Heine, U Zähringer, ... Walter de Gruyter 387 (3), 301-310, 2006 | 132 | 2006 |
A new method for the solid phase synthesis of oligosaccharides J Rademann, RR Schmidt Tetrahedron letters 37 (23), 3989-3990, 1996 | 130 | 1996 |
Physical properties of poly (ethylene glycol)(PEG)-based resins for combinatorial solid phase organic chemistry: a comparison of PEG-cross-linked and PEG-grafted resins M Grøtli, CH Gotfredsen, J Rademann, J Buchardt, AJ Clark, JØ Duus, ... Journal of Combinatorial Chemistry 2 (2), 108-119, 2000 | 125 | 2000 |
Small-molecule scaffolds for CYP51 inhibitors identified by high-throughput screening and defined by X-ray crystallography LM Podust, JP von Kries, AN Eddine, Y Kim, LV Yermalitskaya, R Kuehne, ... Antimicrobial agents and chemotherapy 51 (11), 3915-3923, 2007 | 106 | 2007 |
Oxoammonium Resins as Metal-Free, Highly Reactive, Versatile Polymeric Oxidation Reagents. S Weik, G Nicholson, G Jung, J Rademann Angewandte Chemie (International ed. in English) 40 (8), 1436-1439, 2001 | 93 | 2001 |
Design of chemical libraries with potentially bioactive molecules applying a maximum common substructure concept M Lisurek, B Rupp, J Wichard, M Neuenschwander, JP von Kries, R Frank, ... Molecular diversity 14, 401-408, 2010 | 91 | 2010 |
Identification and validation of larixyl acetate as a potent TRPC6 inhibitor N Urban, L Wang, S Kwiek, J Rademann, WM Kuebler, M Schaefer Molecular pharmacology 89 (1), 197-213, 2016 | 89 | 2016 |
Selective inhibitors of the protein tyrosine phosphatase SHP2 block cellular motility and growth of cancer cells in vitro and in vivo S Grosskopf, C Eckert, C Arkona, S Radetzki, K Böhm, U Heinemann, ... ChemMedChem 10 (5), 815-826, 2015 | 89 | 2015 |
Sensitized detection of inhibitory fragments and iterative development of non‐peptidic protease inhibitors by dynamic ligation screening MF Schmidt, A Isidro‐Llobet, M Lisurek, A El‐Dahshan, J Tan, ... Angewandte Chemie International Edition 47 (17), 3275-3278, 2008 | 87 | 2008 |
Solid‐Phase Supported Synthesis of the Branched Pentasaccharide Moiety That Occurs in Most Complex Type N‐Glycan Chains J Rademann, A Geyer, RR Schmidt Angewandte Chemie International Edition 37 (9), 1241-1245, 1998 | 86 | 1998 |
Chemical synthesis of a glycolipid library by a solid‐phase strategy allows elucidation of the structural specificity of immunostimulation by rhamnolipids J Bauer, K Brandenburg, U Zähringer, J Rademann Chemistry–A European Journal 12 (27), 7116-7124, 2006 | 85 | 2006 |
Discovery of Mycobacterium tuberculosis protein tyrosine phosphatase A (MptpA) inhibitors based on natural products and a fragment‐based approach M Manger, M Scheck, H Prinz, JP Von Kries, T Langer, K Saxena, ... ChemBioChem 6 (10), 1749-1753, 2005 | 85 | 2005 |