Jorrit Hornberg
Jorrit Hornberg
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Cancer: a systems biology disease
JJ Hornberg, FJ Bruggeman, HV Westerhoff, J Lankelma
Biosystems 83 (2-3), 81-90, 2006
Control of MAPK signalling: from complexity to what really matters
JJ Hornberg, B Binder, FJ Bruggeman, B Schoeberl, R Heinrich, ...
Oncogene 24 (36), 5533-5542, 2005
Principles behind the multifarious control of signal transduction: ERK phosphorylation and kinase/phosphatase control
JJ Hornberg, FJ Bruggeman, B Binder, CR Geest, AJMB De Vaate, ...
The FEBS journal 272 (1), 244-258, 2005
A high content screening assay to predict human drug-induced liver injury during drug discovery
M Persson, AF Løye, T Mow, JJ Hornberg
Journal of Pharmacological and Toxicological Methods 68 (3), 302-313, 2013
Exploratory toxicology as an integrated part of drug discovery. Part I: Why and how
JJ Hornberg, M Laursen, N Brenden, M Persson, AV Thougaard, DB Toft, ...
Drug discovery today 19 (8), 1131-1136, 2014
Metabolic control analysis to identify optimal drug targets
JJ Hornberg, FJ Bruggeman, BM Bakker, HV Westerhoff
Systems Biological Approaches in Infectious Diseases, 171-189, 2007
A potential imprint control element: identification of a conserved 42 bp sequence upstream of H19
MAE Frevel, JJ Hornberg, AE Reeve
Trends in Genetics 15 (6), 216-218, 1999
High‐content analysis/screening for predictive toxicology: application to hepatotoxicity and genotoxicity
M Persson, AF Løye, M Jacquet, NS Mow, AV Thougaard, T Mow, ...
Basic & clinical pharmacology & toxicology 115 (1), 18-23, 2014
Characterization and optimization of a red-shifted fluorescence polarization ADP detection assay
KM Kleman-Leyer, TA Klink, AL Kopp, TA Westermeyer, MD Koeff, ...
Assay and drug development technologies 7 (1), 56-67, 2009
Exploratory toxicology as an integrated part of drug discovery. Part II: Screening strategies
JJ Hornberg, M Laursen, N Brenden, M Persson, AV Thougaard, DB Toft, ...
Drug Discovery Today 19 (8), 1137-1144, 2014
The NosX and NirX proteins of Paracoccus denitrificans are functional homologues: their role in maturation of nitrous oxide reductase
NFW Saunders, JJ Hornberg, WNM Reijnders, HV Westerhoff, S de Vries, ...
Journal of bacteriology 182 (18), 5211-5217, 2000
Retinoid-related orphan receptor γ (RORγ) adult induced knockout mice develop lymphoblastic lymphoma
M Liljevald, M Rehnberg, M Söderberg, M Ramnegård, J Börjesson, ...
Autoimmunity reviews 15 (11), 1062-1070, 2016
Introduction to systems biology
FJ Bruggeman, JJ Hornberg, FC Boogerd, HV Westerhoff
Plant Systems Biology, 1-19, 2007
Use of precision cut lung slices as a translational model for the study of lung biology
G Liu, C Betts, DM Cunoosamy, PM Åberg, JJ Hornberg, KB Sivars, ...
Respiratory research 20 (1), 1-14, 2019
Structure-based lead identification of ATP-competitive MK2 inhibitors
T Barf, A Kaptein, S de Wilde, R van der Heijden, R van Someren, ...
Bioorganic & medicinal chemistry letters 21 (12), 3818-3822, 2011
A novel multi-parametric high content screening assay in ciPTEC-OAT1 to predict drug-induced nephrotoxicity during drug discovery
AK Sjögren, K Breitholtz, E Ahlberg, L Milton, M Forsgard, M Persson, ...
Archives of toxicology 92 (10), 3175-3190, 2018
Synergistic activation of signalling to extracellular signal‐regulated kinases 1 and 2 by epidermal growth factor and 4β‐phorbol 12‐myristate 13‐acetate
JJ Hornberg, MR Tijssen, J Lankelma
European journal of biochemistry 271 (19), 3905-3913, 2004
Advances in predictive toxicology for discovery safety through high content screening
M Persson, JJ Hornberg
Chemical research in toxicology 29 (12), 1998-2007, 2016
Simple drugs do not cure complex diseases: The need for multi-targeted drugs
JJ Hornberg
Designing Multi-Target Drugs, 1-13, 2012
Validation of a high throughput flow cytometric in vitro micronucleus assay including assessment of metabolic activation in TK6 cells
AV Thougaard, J Christiansen, T Mow, JJ Hornberg
Environmental and molecular mutagenesis 55 (9), 704-718, 2014
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