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ALFONSO MENDOZA LOSANA
ALFONSO MENDOZA LOSANA
Other namesAlfonso Mendoza
Investigador Distinguido, UC3M
Verified email at ing.uc3m.es - Homepage
Title
Cited by
Cited by
Year
Fueling open‐source drug discovery: 177 small‐molecule leads against tuberculosis
L Ballell, RH Bates, RJ Young, D Alvarez‐Gomez, E Alvarez‐Ruiz, ...
ChemMedChem 8 (2), 313-321, 2013
3582013
A Murine Model of falciparum-Malaria by In Vivo Selection of Competent Strains in Non-Myelodepleted Mice Engrafted with Human Erythrocytes
I Angulo-Barturen, MB Jiménez-Díaz, T Mulet, J Rullas, E Herreros, ...
PloS one 3 (5), e2252, 2008
1882008
Tetrahydropyrazolo [1, 5-a] pyrimidine-3-carboxamide and N-benzyl-6′, 7′-dihydrospiro [piperidine-4, 4′-thieno [3, 2-c] pyran] analogues with bactericidal efficacy against …
MJ Remuiñán, E Pérez-Herrán, J Rullás, C Alemparte, M Martínez-Hoyos, ...
PloS one 8 (4), e60933, 2013
1522013
Annotated Draft Genomic Sequence from a Streptococcus pneumoniae Type 19F Clinical Isolate
J Dopazo, A Mendoza, J Herrero, F Caldara, Y Humbert, L Friedli, ...
Microbial drug resistance 7 (2), 99-125, 2001
1512001
Discovery of a potent and specific M. tuberculosis Leucyl-tRNA synthetase inhibitor:(S)-3-(Aminomethyl)-4-chloro-7-(2-hydroxyethoxy) benzo [c][1, 2] oxaborol-1 (3 H)-ol (GSK656)
X Li, V Hernandez, FL Rock, W Choi, YSL Mak, M Mohan, W Mao, Y Zhou, ...
Journal of medicinal chemistry 60 (19), 8011-8026, 2017
1412017
Encoded library technology as a source of hits for the discovery and lead optimization of a potent and selective class of bactericidal direct inhibitors of Mycobacterium …
L Encinas, H O’Keefe, M Neu, MJ Remuiñán, AM Patel, A Guardia, ...
Journal of Medicinal Chemistry 57 (4), 1276-1288, 2014
1212014
Discovery of novel oral protein synthesis inhibitors of Mycobacterium tuberculosis that target leucyl-tRNA synthetase
A Palencia, X Li, W Bu, W Choi, CZ Ding, EE Easom, L Feng, ...
Antimicrobial agents and chemotherapy 60 (10), 6271-6280, 2016
1092016
N-methylation of a bactericidal compound as a resistance mechanism in Mycobacterium tuberculosis
T Warrier, K Kapilashrami, A Argyrou, TR Ioerger, D Little, KC Murphy, ...
Proceedings of the National Academy of Sciences 113 (31), E4523-E4530, 2016
1092016
Inhibiting the stringent response blocks Mycobacterium tuberculosis entry into quiescence and reduces persistence
NK Dutta, LG Klinkenberg, MJ Vazquez, D Segura-Carro, G Colmenarejo, ...
Science Advances 5 (3), eaav2104, 2019
1062019
Streptomycin-starved Mycobacterium tuberculosis 18b, a drug discovery tool for latent tuberculosis
M Zhang, C Sala, RC Hartkoorn, N Dhar, A Mendoza-Losana, ST Cole
Antimicrobial agents and chemotherapy 56 (11), 5782-5789, 2012
1032012
The Candida albicans PKC1 gene encodes a protein kinase C homolog necessary for cellular integrity but not dimorphism
G Paravicini, A Mendoza, B Antonsson, M Cooper, C Losberger, ...
Yeast 12 (8), 741-756, 1996
1001996
Identification of KasA as the cellular target of an anti-tubercular scaffold
KA Abrahams, C Chung, S Ghidelli-Disse, J Rullas, MJ Rebollo-López, ...
Nature communications 7 (1), 12581, 2016
912016
Repurposing clinically approved cephalosporins for tuberculosis therapy
S Ramón-García, R González del Río, AS Villarejo, GD Sweet, ...
Scientific reports 6 (1), 34293, 2016
882016
Characterization of SKM1, a Saccharomyces cerevisiae gene encoding a novel Ste20/PAK‐like protein kinase
H Martín, A Mendoza, JM Rodríguez‐Pachón, M Molina, C Nombela
Molecular microbiology 23 (3), 431-444, 1997
851997
Development of an intracellular screen for new compounds able to inhibit Mycobacterium tuberculosis growth in human macrophages
F Sorrentino, R Gonzalez del Rio, X Zheng, J Presa Matilla, ...
Antimicrobial agents and chemotherapy 60 (1), 640-645, 2016
802016
Translation elongation factor 2 is part of the target for a new family of antifungals
L Capa, A Mendoza, JL Lavandera, F Gómez de las Heras, ...
Antimicrobial agents and chemotherapy 42 (10), 2694-2699, 1998
801998
Prioritizing multiple therapeutic targets in parallel using automated DNA-encoded library screening
CA Machutta, CS Kollmann, KE Lind, X Bai, PF Chan, J Huang, L Ballell, ...
Nature communications 8 (1), 16081, 2017
732017
First-time-in-human study and prediction of early bactericidal activity for GSK3036656, a potent leucyl-tRNA synthetase inhibitor for tuberculosis treatment
D Tenero, G Derimanov, A Carlton, J Tonkyn, M Davies, S Cozens, ...
Antimicrobial agents and chemotherapy 63 (8), 10.1128/aac. 00240-19, 2019
662019
Antitubercular drugs for an old target: GSK693 as a promising InhA direct inhibitor
M Martínez-Hoyos, E Perez-Herran, G Gulten, L Encinas, ...
EBioMedicine 8, 291-301, 2016
662016
Novel insight into the reaction of nitro, nitroso and hydroxylamino benzothiazinones and of benzoxacinones with Mycobacterium tuberculosis DprE1
A Richter, I Rudolph, U Möllmann, K Voigt, C Chung, OMP Singh, M Rees, ...
Scientific reports 8 (1), 13473, 2018
502018
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