Hiroaki Wakimoto
Hiroaki Wakimoto
Massachusetts General Hospital, Harvard Medical School
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Single-cell RNA-seq highlights intratumoral heterogeneity in primary glioblastoma
AP Patel, I Tirosh, JJ Trombetta, AK Shalek, SM Gillespie, H Wakimoto, ...
Science 344 (6190), 1396-1401, 2014
An integrative model of cellular states, plasticity, and genetics for glioblastoma
C Neftel, J Laffy, MG Filbin, T Hara, ME Shore, GJ Rahme, AR Richman, ...
Cell 178 (4), 835-849. e21, 2019
Reconstructing and reprogramming the tumor-propagating potential of glioblastoma stem-like cells
ML Suvā, E Rheinbay, SM Gillespie, AP Patel, H Wakimoto, SD Rabkin, ...
Cell 157 (3), 580-594, 2014
Decoupling genetics, lineages, and microenvironment in IDH-mutant gliomas by single-cell RNA-seq
AS Venteicher, I Tirosh, C Hebert, K Yizhak, C Neftel, MG Filbin, ...
Science 355 (6332), eaai8478, 2017
Assessment of therapeutic efficacy and fate of engineered human mesenchymal stem cells for cancer therapy
LS Sasportas, R Kasmieh, H Wakimoto, S Hingtgen, JAJM van de Water, ...
Proceedings of the national academy of sciences 106 (12), 4822-4827, 2009
Alternative lengthening of telomeres renders cancer cells hypersensitive to ATR inhibitors
RL Flynn, KE Cox, M Jeitany, H Wakimoto, AR Bryll, NJ Ganem, F Bersani, ...
Science 347 (6219), 273-277, 2015
Adaptive chromatin remodeling drives glioblastoma stem cell plasticity and drug tolerance
BB Liau, C Sievers, LK Donohue, SM Gillespie, WA Flavahan, TE Miller, ...
Cell stem cell 20 (2), 233-246. e7, 2017
Human glioblastoma–derived cancer stem cells: Establishment of invasive glioma models and treatment with oncolytic herpes simplex virus vectors
H Wakimoto, S Kesari, CJ Farrell, WT Curry Jr, C Zaupa, M Aghi, T Kuroda, ...
Cancer research 69 (8), 3472-3481, 2009
Extreme vulnerability of IDH1 mutant cancers to NAD+ depletion
K Tateishi, H Wakimoto, AJ Iafrate, S Tanaka, F Loebel, N Lelic, ...
Cancer cell 28 (6), 773-784, 2015
Oncolytic virus therapy of multiple tumors in the brain requires suppression of innate and elicited antiviral responses
K Ikeda, T Ichikawa, H Wakimoto, JS Silver, TS Deisboeck, D Finkelstein, ...
Nature medicine 5 (8), 881-887, 1999
CAR-T cells secreting BiTEs circumvent antigen escape without detectable toxicity
BD Choi, X Yu, AP Castano, AA Bouffard, A Schmidts, RC Larson, ...
Nature biotechnology 37 (9), 1049-1058, 2019
TWIST1 promotes invasion through mesenchymal change in human glioblastoma
SA Mikheeva, AM Mikheev, A Petit, R Beyer, RG Oxford, L Khorasani, ...
Molecular cancer 9 (1), 1-18, 2010
Ang-2/VEGF bispecific antibody reprograms macrophages and resident microglia to anti-tumor phenotype and prolongs glioblastoma survival
J Kloepper, L Riedemann, Z Amoozgar, G Seano, K Susek, V Yu, ...
Proceedings of the National Academy of Sciences 113 (16), 4476-4481, 2016
An aberrant transcription factor network essential for Wnt signaling and stem cell maintenance in glioblastoma
E Rheinbay, ML Suvā, SM Gillespie, H Wakimoto, AP Patel, M Shahid, ...
Cell reports 3 (5), 1567-1579, 2013
Interactions between cancer cells and immune cells drive transitions to mesenchymal-like states in glioblastoma
T Hara, R Chanoch-Myers, ND Mathewson, C Myskiw, L Atta, L Bussema, ...
Cancer Cell 39 (6), 779-792. e11, 2021
Maintenance of primary tumor phenotype and genotype in glioblastoma stem cells
H Wakimoto, G Mohapatra, R Kanai, WT Curry, S Yip, M Nitta, AP Patel, ...
Neuro-oncology 14 (2), 132-144, 2011
In Vivo Gene Therapy for α-Fetoprotein-producing Hepatocellular Carcinoma by Adenovirus-mediated Transfer of Cytosine Deaminase Gene
F Kanai, KH Lan, Y Shiratori, T Tanaka, M Ohashi, T Okudaria, Y Yoshida, ...
Cancer research 57 (3), 461-465, 1997
Brain tumor cells in circulation are enriched for mesenchymal gene expression
JP Sullivan, BV Nahed, MW Madden, SM Oliveira, S Springer, D Bhere, ...
Cancer discovery 4 (11), 1299-1309, 2014
Inhibitory CD161 receptor identified in glioma-infiltrating T cells by single-cell analysis
ND Mathewson, O Ashenberg, I Tirosh, S Gritsch, EM Perez, S Marx, ...
Cell 184 (5), 1281-1298. e26, 2021
Prognostic significance of Ki‐67 labeling indices obtained using MIB‐1 monoclonal antibody in patients with supratentorial astrocytomas
H Wakimoto, M Aoyagi, T Nakayama, G Nagashima, S Yamamoto, ...
Cancer: Interdisciplinary International Journal of the American Cancer …, 1996
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Articles 1–20