Professor Lars Kuepfer
Professor Lars Kuepfer
Institute for systems medicine with focus on organ interaction, RWTH Aachen
Bestätigte E-Mail-Adresse bei - Startseite
Zitiert von
Zitiert von
Systematic evaluation of objective functions for predicting intracellular fluxes in Escherichia coli
R Schuetz, L Kuepfer, U Sauer
Molecular systems biology 3 (1), 119, 2007
Large-scale 13C-flux analysis reveals mechanistic principles of metabolic network robustness to null mutations in yeast
LM Blank, L Kuepfer, U Sauer
Genome biology 6, 1-16, 2005
Metabolic functions of duplicate genes in Saccharomyces cerevisiae
L Kuepfer, U Sauer, LM Blank
Genome research 15 (10), 1421-1430, 2005
Applied concepts in PBPK modeling: how to build a PBPK/PD model
L Kuepfer, C Niederalt, T Wendl, JF Schlender, S Willmann, J Lippert, ...
CPT: pharmacometrics & systems pharmacology 5 (10), 516-531, 2016
A computational systems biology software platform for multiscale modeling and simulation: integrating whole-body physiology, disease biology, and molecular reaction networks
T Eissing, L Kuepfer, C Becker, M Block, K Coboeken, T Gaub, L Goerlitz, ...
Frontiers in physiology 2, 4, 2011
Ensemble modeling for analysis of cell signaling dynamics
L Kuepfer, M Peter, U Sauer, J Stelling
Nature biotechnology 25 (9), 1001-1006, 2007
Integrating cellular metabolism into a multiscale whole-body model
M Krauss, S Schaller, S Borchers, R Findeisen, J Lippert, L Kuepfer
PLoS computational biology 8 (10), e1002750, 2012
A systematic evaluation of the use of physiologically based pharmacokinetic modeling for cross-species extrapolation
C Thiel, S Schneckener, M Krauss, A Ghallab, U Hofmann, T Kanacher, ...
Journal of pharmaceutical sciences 104 (1), 191-206, 2015
Model-guided identification of a therapeutic strategy to reduce hyperammonemia in liver diseases
A Ghallab, G Cellière, SG Henkel, D Driesch, S Hoehme, U Hofmann, ...
Journal of hepatology 64 (4), 860-871, 2016
Prediction of human drug-induced liver injury (DILI) in relation to oral doses and blood concentrations
W Albrecht, F Kappenberg, T Brecklinghaus, R Stoeber, R Marchan, ...
Archives of toxicology 93, 1609-1637, 2019
Bile microinfarcts in cholestasis are initiated by rupture of the apical hepatocyte membrane and cause shunting of bile to sinusoidal blood
A Ghallab, U Hofmann, S Sezgin, N Vartak, R Hassan, A Zaza, P Godoy, ...
Hepatology 69 (2), 666-683, 2019
Using expression data for quantification of active processes in physiologically based pharmacokinetic modeling
M Meyer, S Schneckener, B Ludewig, L Kuepfer, J Lippert
Drug Metabolism and Disposition 40 (5), 892-901, 2012
Enabling multiscale modeling in systems medicine
O Wolkenhauer, C Auffray, O Brass, J Clairambault, A Deutsch, D Drasdo, ...
Genome medicine 6, 1-3, 2014
A generic whole body physiologically based pharmacokinetic model for therapeutic proteins in PK-Sim
C Niederalt, L Kuepfer, J Solodenko, T Eissing, HU Siegmund, M Block, ...
Journal of pharmacokinetics and pharmacodynamics 45, 235-257, 2018
Whither systems medicine?
R Apweiler, T Beissbarth, MR Berthold, N Blüthgen, Y Burmeister, ...
Experimental & molecular medicine 50 (3), e453-e453, 2018
In vivo imaging of systemic transport and elimination of xenobiotics and endogenous molecules in mice
R Reif, A Ghallab, L Beattie, G Günther, L Kuepfer, PM Kaye, ...
Archives of toxicology 91, 1335-1352, 2017
Physiologically-based modelling in mice suggests an aggravated loss of clearance capacity after toxic liver damage
A Schenk, A Ghallab, U Hofmann, R Hassan, M Schwarz, A Schuppert, ...
Scientific Reports 7 (1), 6224, 2017
Using Bayesian-PBPK modeling for assessment of inter-individual variability and subgroup stratification
M Krauss, R Burghaus, J Lippert, M Niemi, P Neuvonen, A Schuppert, ...
In Silico Pharmacology 1, 1-11, 2013
Multiscale modelling and simulation
S Attinger, PD Koumoutsakos, Summer Program in Multi-Scale
Springer, 2004
Spatio-temporal simulation of first pass drug perfusion in the liver
LO Schwen, M Krauss, C Niederalt, F Gremse, F Kiessling, A Schenk, ...
PLoS computational biology 10 (3), e1003499, 2014
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