Bradley R Clarke
Bradley R Clarke
Research Associate, University of Guelph
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Wza the translocon for E. coli capsular polysaccharides defines a new class of membrane protein
C Dong, K Beis, J Nesper, AL Brunkan-LaMontagne, BR Clarke, ...
Nature 444 (7116), 226-229, 2006
Substrate specificity of bacterial oligosaccharyltransferase suggests a common transfer mechanism for the bacterial and eukaryotic systems
M Wacker, MF Feldman, N Callewaert, M Kowarik, BR Clarke, NL Pohl, ...
Proceedings of the National Academy of Sciences 103 (18), 7088-7093, 2006
The 3D structure of a periplasm-spanning platform required for assembly of group 1 capsular polysaccharides in Escherichia coli
RF Collins, K Beis, C Dong, CH Botting, C McDonnell, RC Ford, ...
Proceedings of the National Academy of Sciences 104 (7), 2390-2395, 2007
Nonreducing terminal modifications determine the chain length of polymannose O antigens of Escherichia coli and couple chain termination to polymer export via an ATP-binding …
BR Clarke, L Cuthbertson, C Whitfield
Journal of Biological Chemistry 279 (34), 35709-35718, 2004
Identification of an ATP‐binding cassette transport system required for translocation of lipopolysaccharide O‐antigen side‐chains across the cytoplasmic membrane of Klebsiella …
D Bronner, BR Clarke, C Whitfield
Molecular microbiology 14 (3), 505-519, 1994
Expression of two structurally distinct D-galactan O antigens in the lipopolysaccharide of Klebsiella pneumoniae serotype O1
C Whitfield, JC Richards, MB Perry, BR Clarke, LL MacLean
Journal of bacteriology 173 (4), 1420-1431, 1991
Regulation of the Escherichia coli K5 capsule gene cluster by transcription antitermination
MP Stevens, BR Clarke, IS Roberts
Molecular microbiology 24 (5), 1001-1012, 1997
Periplasmic protein-protein contacts in the inner membrane protein Wzc form a tetrameric complex required for the assembly of Escherichia coli group 1 capsules
RF Collins, K Beis, BR Clarke, RC Ford, M Hulley, JH Naismith, ...
Journal of Biological Chemistry 281 (4), 2144-2150, 2006
Role of Rfe and RfbF in the initiation of biosynthesis of D-galactan I, the lipopolysaccharide O antigen from Klebsiella pneumoniae serotype O1
BR Clarke, D Bronner, WJ Keenleyside, WB Severn, JC Richards, ...
Journal of bacteriology 177 (19), 5411-5418, 1995
Molecular cloning of the rfb region of Klebsiella pneumoniae serotype O1: K20: the rfb gene cluster is responsible for synthesis of the D-galactan IO polysaccharide
BR Clarke, C Whitfield
Journal of bacteriology 174 (14), 4614-4621, 1992
A high-molecular-weight fraction of smooth lipopolysaccharide in Klebsiella serotype O1: K20 contains a unique O-antigen epitope and determines resistance to nonspecific serum …
KL McCALLUM, G Schoenhals, D Laakso, B Clarke, C Whitfield
Infection and immunity 57 (12), 3816-3822, 1989
Cloning, expression, and purification of the K5 capsular polysaccharide lyase (KflA) from coliphage K5A: evidence for two distinct K5 lyase enzymes
BR Clarke, F Esumeh, IS Roberts
Journal of Bacteriology 182 (13), 3761-3766, 2000
A coiled-coil domain acts as a molecular ruler to regulate O-antigen chain length in lipopolysaccharide
G Hagelueken, BR Clarke, H Huang, A Tuukkanen, I Danciu, DI Svergun, ...
Nature structural & molecular biology 22 (1), 50-56, 2015
Genetic Organization of the Escherichia coli K10 Capsule Gene Cluster: Identification and Characterization of Two Conserved Regions in Group III Capsule Gene …
BR Clarke, R Pearce, IS Roberts
Journal of bacteriology 181 (7), 2279-2285, 1999
Lipopolysaccharide O antigen size distribution is determined by a chain extension complex of variable stoichiometry in Escherichia coli O9a
JD King, S Berry, BR Clarke, RJ Morris, C Whitfield
Proceedings of the National Academy of Sciences 111 (17), 6407-6412, 2014
Molecular basis for the structural diversity in serogroup O2-antigen polysaccharides in Klebsiella pneumoniae
BR Clarke, OG Ovchinnikova, SD Kelly, ML Williamson, JE Butler, B Liu, ...
Journal of Biological Chemistry 293 (13), 4666-4679, 2018
Coordination of polymerization, chain termination, and export in assembly of the Escherichia coli lipopolysaccharide O9a antigen in an ATP-binding cassette transporter …
BR Clarke, LK Greenfield, C Bouwman, C Whitfield
Journal of biological chemistry 284 (44), 30662-30672, 2009
In vitro reconstruction of the chain termination reaction in biosynthesis of the Escherichia coli O9a O-polysaccharide: The chain-length regulator, WbdD, catalyzes the addition …
BR Clarke, MR Richards, LK Greenfield, D Hou, TL Lowary, C Whitfield
Journal of Biological Chemistry 286 (48), 41391-41401, 2011
Full-length, oligomeric structure of Wzz determined by cryoelectron microscopy reveals insights into membrane-bound states
RF Collins, V Kargas, BR Clarke, CA Siebert, DK Clare, PJ Bond, ...
Structure 25 (5), 806-815. e3, 2017
A bifunctional O-antigen polymerase structure reveals a new glycosyltransferase family
BR Clarke, OG Ovchinnikova, RP Sweeney, ER Kamski-Hennekam, ...
Nature chemical biology 16 (4), 450-457, 2020
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