| Druggability analysis and structural classification of bromodomain acetyl-lysine binding sites LR Vidler, N Brown, S Knapp, S Hoelder Journal of medicinal chemistry 55 (17), 7346-7359, 2012 | 312 | 2012 |
| Discovery of novel small-molecule inhibitors of BRD4 using structure-based virtual screening LR Vidler, P Filippakopoulos, O Fedorov, S Picaud, S Martin, M Tomsett, ... Journal of medicinal chemistry 56 (20), 8073-8088, 2013 | 157 | 2013 |
| Structure enabled design of BAZ2-ICR, a chemical probe targeting the bromodomains of BAZ2A and BAZ2B L Drouin, S McGrath, LR Vidler, A Chaikuad, O Monteiro, C Tallant, ... Journal of medicinal chemistry 58 (5), 2553-2559, 2015 | 119 | 2015 |
| Epilepsy-associated GRIN2A mutations reduce NMDA receptor trafficking and agonist potency – molecular profiling and functional rescue L Addis, JK Virdee, LR Vidler, DA Collier, DK Pal, D Ursu Scientific reports 7 (1), 66, 2017 | 84 | 2017 |
| Changing the local coordination environment in mono-and bi-nuclear lanthanide complexes through “click” chemistry M Jauregui, WS Perry, C Allain, LR Vidler, MC Willis, AM Kenwright, ... Dalton transactions, 6283-6285, 2009 | 54 | 2009 |
| Design and Synthesis of 56 Shape‐Diverse 3D Fragments TD Downes, SP Jones, HF Klein, MC Wheldon, M Atobe, PS Bond, ... Chemistry (Weinheim an der Bergstrasse, Germany) 26 (41), 8969, 2020 | 41 | 2020 |
| Gene-set analysis based on the pharmacological profiles of drugs to identify repurposing opportunities in schizophrenia S De Jong, LR Vidler, Y Mokrab, DA Collier, G Breen Journal of psychopharmacology 30 (8), 826-830, 2016 | 27 | 2016 |
| Investigating the behavior of published PAINS alerts using a pharmaceutical company data set LR Vidler, IA Watson, BJ Margolis, DJ Cummins, M Brunavs ACS Medicinal Chemistry Letters 9 (8), 792-796, 2018 | 23 | 2018 |
| Structure‐Enabled Discovery of a Stapled Peptide Inhibitor to Target the Oncogenic Transcriptional Repressor TLE1 S McGrath, M Tortorici, L Drouin, S Solanki, L Vidler, I Westwood, ... Chemistry–A European Journal 23 (40), 9577-9584, 2017 | 14 | 2017 |
| Creating a virtual assistant for medicinal chemistry LR Vidler, MP Baumgartner ACS Medicinal Chemistry Letters 10 (7), 1051-1055, 2019 | 12 | 2019 |
| Solution structure of the Hop TPR2A domain and investigation of target druggability by NMR, biochemical and in silico approaches JF Darby, LR Vidler, PJ Simpson, B Al-Lazikani, SJ Matthews, SY Sharp, ... Scientific reports 10 (1), 16000, 2020 | 9 | 2020 |
| A comparative assessment study of known small-molecule GPVI modulators H Foster, C Wilson, JS Gauer, RG Xu, MJ Howard, IW Manfield, R Ariëns, ... ACS Medicinal Chemistry Letters 13 (2), 171-181, 2022 | 7 | 2022 |
| TractaViewer: a genome-wide tool for preliminary assessment of therapeutic target druggability N Pearson, K Malki, D Evans, L Vidler, C Ruble, J Scherschel, ... Bioinformatics 35 (21), 4509-4510, 2019 | 4 | 2019 |
| Beyond PAINs: Chemotype Sensitivity of Protein Methyltransferases in Screens C Gao, BJ Margolis, JM Strelow, LR Vidler, MM Mader ACS Medicinal Chemistry Letters 7 (2), 156-161, 2016 | 4 | 2016 |
| Design of Novel Series of Antimalarial PMX Inhibitors with Increased Half-Life via Molecular Property Optimization K Sakata, MA Lowe, M Xuan, J Bruffaerts, LP Stasi, B Lallemand, ... ACS Medicinal Chemistry Letters 14 (11), 1582-1588, 2023 | | 2023 |
| Exploration of piperidine 3D fragment chemical space: synthesis and 3D shape analysis of fragments derived from 20 regio-and diastereoisomers of methyl substituted pipecolinates SP Jones, JD Firth, MC Wheldon, M Atobe, RE Hubbard, DC Blakemore, ... RSC Medicinal Chemistry 13 (12), 1614-1620, 2022 | | 2022 |
| Design and Synthesis of 56 Shape Diverse 3-D Fragments P O'Brien, TD Downes, SP Jones, HF Klein, MC Wheldon, M Atobe, ... Chemistry: A European Journal, 2020 | | 2020 |
| Developing Kernel, a virtual assistant for medicinal chemistry discovery teams at Eli Lilly M Baumgartner, L Vidler ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY 258, 2019 | | 2019 |
| GENE-SET ANALYSIS BASED ON THE PHARMACOLOGICAL PROFILES OF DRUGS TO IDENTIFY REPURPOSING OPPORTUNITIES IN SCHIZOPHRENIA S de Jong, L Vidler, Y Mokrab, D Collier, G Breen EUROPEAN NEUROPSYCHOPHARMACOLOGY 27, S195-S195, 2017 | | 2017 |
| Abstract B99: Targeting TPR cochaperones of the Hsp90 molecular chaperone complex for specific inhibition. JF Darby, L Vidler, PJ Simpson, S Sharp, C Prodromou, S Matthews, ... Molecular Cancer Therapeutics 10 (11_Supplement), B99-B99, 2011 | | 2011 |
Stefan KnappUniversity of FrankfurtBestätigte E-Mail-Adresse bei pharmchem.uni-frankfurt.de
