John N Hutchinson
John N Hutchinson
Senior Scientific Consultant, Diamond Age Data Science
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An architectural role for a nuclear noncoding RNA: NEAT1 RNA is essential for the structure of paraspeckles
CM Clemson, JN Hutchinson, SA Sara, AW Ensminger, AH Fox, A Chess, ...
Molecular cell 33 (6), 717-726, 2009
A screen for nuclear transcripts identifies two linked noncoding RNAs associated with SC35 splicing domains
JN Hutchinson, AW Ensminger, CM Clemson, CR Lynch, JB Lawrence, ...
BMC genomics 8, 1-16, 2007
Widespread monoallelic expression on human autosomes
A Gimelbrant, JN Hutchinson, BR Thompson, A Chess
Science 318 (5853), 1136-1140, 2007
Caveolin-1 gene disruption promotes mammary tumorigenesis and dramatically enhances lung metastasis in vivo: role of Cav-1 in cell invasiveness and matrix metalloproteinase …
TM Williams, F Medina, I Badano, RB Hazan, J Hutchinson, WJ Muller, ...
Journal of Biological Chemistry 279 (49), 51630-51646, 2004
Activation of Akt (protein kinase B) in mammary epithelium provides a critical cell survival signal required for tumor progression
J Hutchinson, J Jin, RD Cardiff, JR Woodgett, WJ Muller
Molecular and cellular biology 21 (6), 2203-2212, 2001
Activation of Akt-1 (PKB-α) can accelerate ErbB-2-mediated mammary tumorigenesis but suppresses tumor invasion
JN Hutchinson, J Jin, RD Cardiff, JR Woodgett, WJ Muller
Cancer research 64 (9), 3171-3178, 2004
Requirement for both Shc and phosphatidylinositol 3′ kinase signaling pathways in polyomavirus middle T-mediated mammary tumorigenesis
MA Webster, JN Hutchinson, MJ Rauh, SK Muthuswamy, M Anton, ...
Molecular and cellular biology 18 (4), 2344-2359, 1998
Transgenic mouse models of human breast cancer
JN Hutchinson, WJ Muller
Oncogene 19 (53), 6130-6137, 2000
IL-1β inflammatory response driven by primary breast cancer prevents metastasis-initiating cell colonization
Z Castano, BP San Juan, A Spiegel, A Pant, MJ DeCristo, T Laszewski, ...
Nature cell biology 20 (9), 1084-1097, 2018
Interferon signaling is diminished with age and is associated with immune checkpoint blockade efficacy in triple-negative breast cancer
J Sceneay, GJ Goreczny, K Wilson, S Morrow, MJ DeCristo, ...
Cancer Discovery 9 (9), 1208-1227, 2019
Aldehyde dehydrogenase 3a2 protects AML cells from oxidative death and the synthetic lethality of ferroptosis inducers
RZ Yusuf, B Saez, A Sharda, N Van Gastel, VWC Yu, N Baryawno, ...
Blood, The Journal of the American Society of Hematology 136 (11), 1303-1316, 2020
RNA sequencing identifies novel translational biomarkers of kidney fibrosis
FL Craciun, V Bijol, AK Ajay, P Rao, RK Kumar, J Hutchinson, O Hofmann, ...
Journal of the American society of nephrology 27 (6), 1702-1713, 2016
Short-term airborne particulate matter exposure alters the epigenetic landscape of human genes associated with the mitogen-activated protein kinase network: a cross-sectional study
JJ Carmona, T Sofer, J Hutchinson, L Cantone, B Coull, A Maity, ...
Environmental Health 13, 1-14, 2014
Silencing SMOC2 ameliorates kidney fibrosis by inhibiting fibroblast to myofibroblast transformation
C Gerarduzzi, RK Kumar, P Trivedi, AK Ajay, A Iyer, S Boswell, ...
JCI insight 2 (8), 2017
Allele-specific methylation occurs at genetic variants associated with complex disease
JN Hutchinson, T Raj, J Fagerness, E Stahl, FT Viloria, A Gimelbrant, ...
PloS one 9 (6), e98464, 2014
bcbioRNASeq: R package for bcbio RNA-seq analysis
MJ Steinbaugh, L Pantano, RD Kirchner, V Barrera, BA Chapman, ...
F1000Research 6 (1976), 1976, 2017
Empirical comparison of reduced representation bisulfite sequencing and Infinium BeadChip reproducibility and coverage of DNA methylation in humans
JJ Carmona, WP Accomando Jr, AM Binder, JN Hutchinson, L Pantano, ...
NPJ genomic medicine 2 (1), 13, 2017
Augmented responses to ozone in obese mice require IL-17A and gastrin-releasing peptide
JA Mathews, N Krishnamoorthy, DI Kasahara, J Hutchinson, Y Cho, ...
American journal of respiratory cell and molecular biology 58 (3), 341-351, 2018
Integrative omics provide biological and clinical insights into acute respiratory distress syndrome
M Du, JGN Garcia, JD Christie, J Xin, G Cai, NJ Meyer, Z Zhu, Q Yuan, ...
Intensive care medicine 47 (7), 761-771, 2021
Epigenomic analysis of 5-hydroxymethylcytosine (5hmC) reveals novel DNA methylation markers for lung cancers
Z Wang, M Du, Q Yuan, Y Guo, JN Hutchinson, L Su, Y Zheng, J Wang, ...
Neoplasia 22 (3), 154-161, 2020
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