Paul Brear
Paul Brear
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Specific inhibition of CK2α from an anchor outside the active site
P Brear, C De Fusco, KH Georgiou, NJ Francis-Newton, CJ Stubbs, ...
Chemical science 7 (11), 6839-6845, 2016
ALDH2 mediates 5-nitrofuran activity in multiple species
L Zhou, H Ishizaki, M Spitzer, KL Taylor, ND Temperley, SL Johnson, ...
Chemistry & biology 19 (7), 883-892, 2012
A fragment-based approach leading to the discovery of a novel binding site and the selective CK2 inhibitor CAM4066
C De Fusco, P Brear, J Iegre, KH Georgiou, HF Sore, M Hyv÷nen, ...
Bioorganic & medicinal chemistry 25 (13), 3471-3482, 2017
Gluconeogenic precursor availability regulates flux through the glyoxylate shunt in Pseudomonas aeruginosa
A Crousilles, SK Dolan, P Brear, DY Chirgadze, M Welch
Journal of Biological Chemistry 293 (37), 14260-14269, 2018
Novel non-ATP competitive small molecules targeting the CK2 α/β interface
P Brear, A North, J Iegre, KH Georgiou, A Lubin, L Carro, W Green, ...
Bioorganic & medicinal chemistry 26 (11), 3016-3020, 2018
Second-generation CK2α inhibitors targeting the αD pocket
J Iegre, P Brear, C De Fusco, M Yoshida, SL Mitchell, M Rossmann, ...
Chemical science 9 (11), 3041-3049, 2018
A random forest model for predicting allosteric and functional sites on proteins
ASY Chen, NJ Westwood, P Brear, GW Rogers, L Mavridis, JBO Mitchell
Molecular informatics 35 (3‐4), 125-135, 2016
Efficient development of stable and highly functionalised peptides targeting the CK2α/CK2β protein–protein interaction
J Iegre, P Brear, DJ Baker, YS Tan, EL Atkinson, HF Sore, DH O'Donovan, ...
Chemical science 10 (19), 5056-5063, 2019
Chain alignment of collagen I deciphered using computationally designed heterotrimers
AA Jalan, D Sammon, JD Hartgerink, P Brear, K Stott, SW Hamaia, ...
Nature chemical biology 16 (4), 423-429, 2020
Synthesis and Structural Characterisation of Selective Non‐Carbohydrate‐Based Inhibitors of Bacterial Sialidases
P Brear, J Telford, GL Taylor, NJ Westwood
ChemBioChem 13 (16), 2374-2383, 2012
Discovery of holoenzyme-disrupting chemicals as substrate-selective CK2 inhibitors
I Kufareva, B Bestgen, P Brear, R Prudent, B Laudet, V Moucadel, ...
Scientific reports 9 (1), 1-16, 2019
Aqueous methods for the preparation of 5′-substituted guanosine derivatives
P Brear, GR Freeman, MC Shankey, M Trmčić, DRW Hodgson
Chemical communications, 4980-4981, 2009
Proposed allosteric inhibitors bind to the ATP site of CK2α
P Brear, D Ball, K Stott, S D’Arcy, M Hyvönen
Journal of medicinal chemistry 63 (21), 12786-12798, 2020
Demonstration of the utility of DOS-derived fragment libraries for rapid hit derivatisation in a multidirectional fashion
SL Kidd, E Fowler, T Reinhardt, T Compton, N Mateu, H Newman, ...
Chemical science 11 (39), 10792-10801, 2020
Targeting of Fumarate Hydratase from Mycobacterium tuberculosis Using Allosteric Inhibitors with a Dimeric-Binding Mode
AJ Whitehouse, MDJ Libardo, M Kasbekar, PD Brear, G Fischer, ...
Journal of Medicinal Chemistry 62 (23), 10586-10604, 2019
Chemical probes targeting the kinase CK2: A journey outside the catalytic box
J Iegre, EL Atkinson, PD Brear, BM Cooper, M Hyv÷nen, DR Spring
Organic & Biomolecular Chemistry 19 (20), 4380-4396, 2021
Downfalls of chemical probes acting at the kinase ATP-site: CK2 as a case study
EL Atkinson, J Iegre, PD Brear, EA Zhabina, M Hyv÷nen, DR Spring
Molecules 26 (7), 1977, 2021
Evolutionary plasticity in the allosteric regulator-binding site of pyruvate kinase isoform PykA from Pseudomonas aeruginosa
Y Abdelhamid, P Brear, J Greenhalgh, X Chee, T Rahman, M Welch
Journal of Biological Chemistry 294 (42), 15505-15516, 2019
Aqueous synthesis of N, S-dialkylthiophosphoramidates: design, optimisation and application to library construction and antileishmanial testing
M Trmčić, FL Chadbourne, PM Brear, PW Denny, SL Cobb, ...
Organic & Biomolecular Chemistry 11 (16), 2660-2675, 2013
From Data Mining of Chitinophaga sp. Genome to Enzyme Discovery of a Hyperthermophilic Metallocarboxypeptidase
GC Fernandes, EGM Sierra, P Brear, MR Pereira, EGM Lemos
Microorganisms 9 (2), 393, 2021
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Articles 1–20