| Crosstalk and signaling switches in mitogen-activated protein kinase cascades D Fey, DR Croucher, W Kolch, BN Kholodenko Frontiers in physiology 3, 355, 2012 | 186 | 2012 |
| Frequency modulation of ERK activation dynamics rewires cell fate H Ryu, M Chung, M Dobrzyński, D Fey, Y Blum, SS Lee, M Peter, ... Molecular systems biology 11 (11), 838, 2015 | 182 | 2015 |
| Signaling pathway models as biomarkers: Patient-specific simulations of JNK activity predict the survival of neuroblastoma patients D Fey, M Halasz, D Dreidax, SP Kennedy, JF Hastings, N Rauch, ... Science signaling 8 (408), ra130-ra130, 2015 | 145 | 2015 |
| The extracellular matrix as a key regulator of intracellular signalling networks JF Hastings, JN Skhinas, D Fey, DR Croucher, TR Cox British journal of pharmacology 176 (1), 82-92, 2019 | 118 | 2019 |
| Exact model reduction of combinatorial reaction networks H Conzelmann, D Fey, ED Gilles BMC systems biology 2 (1), 1-25, 2008 | 71 | 2008 |
| The complexities and versatility of the RAS-to-ERK signalling system in normal and cancer cells D Fey, D Matallanas, J Rauch, OS Rukhlenko, BN Kholodenko Seminars in cell & developmental biology 58, 96-107, 2016 | 69 | 2016 |
| PP1 initiates the dephosphorylation of MASTL, triggering mitotic exit and bistability in human cells S Rogers, D Fey, RA McCloy, BL Parker, NJ Mitchell, RJ Payne, RJ Daly, ... Journal of cell science 129 (7), 1340-1354, 2016 | 55 | 2016 |
| Pseudophosphatase STYX modulates cell-fate decisions and cell migration by spatiotemporal regulation of ERK1/2 V Reiterer, D Fey, W Kolch, BN Kholodenko, H Farhan Proceedings of the National Academy of Sciences 110 (31), E2934-E2943, 2013 | 49 | 2013 |
| MASTL overexpression promotes chromosome instability and metastasis in breast cancer S Rogers, RA McCloy, BL Parker, D Gallego-Ortega, AMK Law, VT Chin, ... Oncogene 37 (33), 4518-4533, 2018 | 47 | 2018 |
| Performance of objective functions and optimisation procedures for parameter estimation in system biology models A Degasperi, D Fey, BN Kholodenko NPJ systems biology and applications 3 (1), 20, 2017 | 47 | 2017 |
| Integrative omics reveals MYCN as a global suppressor of cellular signalling and enables network-based therapeutic target discovery in neuroblastoma DJ Duffy, A Krstic, M Halasz, T Schwarzl, D Fey, K Iljin, JP Mehta, K Killick, ... Oncotarget 6 (41), 43182, 2015 | 34 | 2015 |
| Wnt signalling is a bi-directional vulnerability of cancer cells DJ Duffy, A Krstic, T Schwarzl, M Halasz, K Iljin, D Fey, B Haley, J Whilde, ... Oncotarget 7 (37), 60310, 2016 | 31 | 2016 |
| Polyubiquitin chain assembly and organization determine the dynamics of protein activation and degradation LK Nguyen, M Dobrzyński, D Fey, BN Kholodenko Frontiers in physiology 5, 4, 2014 | 31 | 2014 |
| Frequency modulation of ERK activation dynamics rewires cell fate H Ryu, M Chung, M Dobrzyński, D Fey, Y Blum, SS Lee, M Peter, ... Molecular systems biology 12 (4), 2016 | 29 | 2016 |
| Parameter estimation in kinetic reaction models using nonlinear observers facilitated by model extensions D Fey, R Findeisen, E Bullinger Proc. 17th IFAC World Congres, Seoul, 313-318, 2008 | 24 | 2008 |
| Personalized computational models as biomarkers W Kolch, D Fey Journal of personalized medicine 7 (3), 9, 2017 | 16 | 2017 |
| Applications of personalised signalling network models in precision oncology JF Hastings, YEI O'Donnell, D Fey, DR Croucher Pharmacology & Therapeutics 212, 107555, 2020 | 14 | 2020 |
| Control of the G-protein cascade dynamics by GDP dissociation inhibitors E Nikonova, MA Tsyganov, W Kolch, D Fey, BN Kholodenko Molecular bioSystems 9 (10), 2454-2462, 2013 | 14 | 2013 |
| Accurate prediction of kinase-substrate networks using knowledge graphs V Nováček, G McGauran, D Matallanas, A Vallejo Blanco, P Conca, ... PLoS computational biology 16 (12), e1007578, 2020 | 13 | 2020 |
| BAX and SMAC regulate bistable properties of the apoptotic caspase system S McKenna, L García-Gutiérrez, D Matallanas, D Fey Scientific reports 11 (1), 3272, 2021 | 12 | 2021 |
Boris KholodenkoProfessor of Systems Biology, University College DublinVerified email at ucd.ie
