Robert Jan Lebbink
Robert Jan Lebbink
Assistant professor UMC Utrecht
Verified email at
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A systematic mammalian genetic interaction map reveals pathways underlying ricin susceptibility
MC Bassik, M Kampmann, RJ Lebbink, S Wang, MY Hein, I Poser, ...
Cell 152 (4), 909-922, 2013
Collagens are functional, high affinity ligands for the inhibitory immune receptor LAIR-1
RJ Lebbink, T de Ruiter, J Adelmeijer, AB Brenkman, JM van Helvoort, ...
The Journal of experimental medicine 203 (6), 1419-1425, 2006
Up-regulation of miR-21 by HER2/neu signaling promotes cell invasion
TH Huang, F Wu, GB Loeb, R Hsu, A Heidersbach, A Brincat, D Horiuchi, ...
Journal of Biological Chemistry 284 (27), 18515-18524, 2009
Efficient intracellular delivery of native proteins
DS D’Astolfo, RJ Pagliero, A Pras, WR Karthaus, H Clevers, V Prasad, ...
Cell 161 (3), 674-690, 2015
The Sulfolobus solfataricus Lrp-like protein LysM regulates lysine biosynthesis in response to lysine availability
AB Brinkman, SD Bell, RJ Lebbink, WM de Vos, J van der Oost
Journal of Biological Chemistry 277 (33), 29537-29549, 2002
CRISPR/Cas9-mediated genome editing of herpesviruses limits productive and latent infections
FR van Diemen, EM Kruse, MJG Hooykaas, CE Bruggeling, AC Schürch, ...
PLoS pathogens 12 (6), 2016
IFI16 is required for DNA sensing in human macrophages by promoting production and function of cGAMP
KL Jĝnsson, A Laustsen, C Krapp, KA Skipper, K Thavachelvam, D Hotter, ...
Nature communications 8 (1), 1-17, 2017
Rapid creation and quantitative monitoring of high coverage shRNA libraries
MC Bassik, RJ Lebbink, LS Churchman, NT Ingolia, W Patena, ...
Nature methods 6 (6), 443, 2009
Influenza A virus targets a cGAS-independent STING pathway that controls enveloped RNA viruses
CK Holm, SH Rahbek, HH Gad, RO Bak, MR Jakobsen, Z Jiang, ...
Nature communications 7 (1), 1-9, 2016
Systematic identification of barriers to human iPSC generation
H Qin, A Diaz, L Blouin, RJ Lebbink, W Patena, P Tanbun, EM LeProust, ...
Cell 158 (2), 449-461, 2014
The soluble leukocyte-associated Ig-like receptor (LAIR)-2 antagonizes the collagen/LAIR-1 inhibitory immune interaction
RJ Lebbink, MCW van den Berg, T de Ruiter, N Raynal, JAG van Roon, ...
The Journal of Immunology 180 (3), 1662-1669, 2008
A high-coverage shRNA screen identifies TMEM129 as an E3 ligase involved in ER-associated protein degradation
ML Van De Weijer, MC Bassik, RD Luteijn, CM Voorburg, MAM Lohuis, ...
Nature communications 5 (1), 1-14, 2014
Identification of multiple potent binding sites for human leukocyte associated Ig-like receptor LAIR on collagens II and III
RJ Lebbink, N Raynal, T de Ruiter, DG Bihan, RW Farndale, L Meyaard
Matrix biology 28 (4), 202-210, 2009
A combinational CRISPR/Cas9 gene-editing approach can halt HIV replication and prevent viral escape
RJ Lebbink, DCM De Jong, F Wolters, EM Kruse, PM Van Ham, ...
Scientific reports 7, 41968, 2017
The mouse homologue of the leukocyte-associated Ig-like receptor-1 is an inhibitory receptor that recruits Src homology region 2-containing protein tyrosine phosphatase (SHP)-2 …
RJ Lebbink, T de Ruiter, A Verbrugge, WS Bril, L Meyaard
The Journal of Immunology 172 (9), 5535-5543, 2004
RhoB mediates phosphoantigen recognition by Vγ9Vδ2 T cell receptor
Z Sebestyen, W Scheper, A Vyborova, S Gu, Z Rychnavska, M Schiffler, ...
Cell reports 15 (9), 1973-1985, 2016
Attenuation of cGAS‐STING signaling is mediated by a p62/SQSTM1‐dependent autophagy pathway activated by TBK1
T Prabakaran, C Bodda, C Krapp, B Zhang, MH Christensen, C Sun, ...
The EMBO journal 37 (8), 2018
Crystal structure and collagen-binding site of immune inhibitory receptor LAIR-1: unexpected implications for collagen binding by platelet receptor GPVI
THC Brondijk, T de Ruiter, J Ballering, H Wienk, RJ Lebbink, H van Ingen, ...
Blood, The Journal of the American Society of Hematology 115 (7), 1364-1373, 2010
Antiviral goes viral: harnessing CRISPR/Cas9 to combat viruses in humans
JA Soppe, RJ Lebbink
Trends in microbiology 25 (10), 833-850, 2017
Signal inhibitory receptor on leukocytes-1 is a novel functional inhibitory immune receptor expressed on human phagocytes
TAM Steevels, RJ Lebbink, GHA Westerlaken, PJ Coffer, L Meyaard
The Journal of Immunology 184 (9), 4741-4748, 2010
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