Roland Brandt
Roland Brandt
Professor of Neurobiology, University of Osnabrück
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Interaction of tau with the neural plasma membrane mediated by tau's amino-terminal projection domain.
R Brandt, J Léger, G Lee
The Journal of cell biology 131 (5), 1327-1340, 1995
CD95 ligand (Fas-L/APO-1L) and tumor necrosis factor-related apoptosis-inducing ligand mediate ischemia-induced apoptosis in neurons
A Martin-Villalba, I Herr, I Jeremias, M Hahne, R Brandt, J Vogel, ...
Journal of Neuroscience 19 (10), 3809-3817, 1999
Molecular interactions among protein phosphatase 2A, tau, and microtubules Implications for the regulation of tau phosphorylation and the development of tauopathies
E Sontag, V Nunbhakdi-Craig, G Lee, R Brandt, C Kamibayashi, J Kuret, ...
Journal of Biological Chemistry 274 (36), 25490-25498, 1999
Tau alteration and neuronal degeneration in tauopathies: mechanisms and models
R Brandt, M Hundelt, N Shahani
Biochimica et Biophysica Acta (BBA)-Molecular Basis of Disease 1739 (2-3 …, 2005
Functional organization of microtubule-associated protein tau. Identification of regions which affect microtubule growth, nucleation, and bundle formation in vitro.
R Brandt, G Lee
Journal of Biological Chemistry 268 (5), 3414-3419, 1993
Process outgrowth of oligodendrocytes is promoted by interaction of fyn kinase with the cytoskeletal protein tau
C Klein, EM Krämer, AM Cardine, B Schraven, R Brandt, J Trotter
Journal of Neuroscience 22 (3), 698-707, 2002
Tau-mediated cytotoxicity in a pseudohyperphosphorylation model of Alzheimer's disease
T Fath, J Eidenmüller, R Brandt
Journal of Neuroscience 22 (22), 9733-9741, 2002
Tau's interaction with the neural membrane cortex is regulated by phosphorylation at sites that are modified in paired helical filaments
T Maas, J Eidenmuller, R Brandt
Journal of Biological Chemistry, 2000
Tau binds to the distal axon early in development of polarity in a microtubule-and microfilament-dependent manner
M Kempf, A Clement, A Faissner, G Lee, R Brandt
Journal of Neuroscience 16 (18), 5583-5592, 1996
Functions and malfunctions of the tau proteins
N Shahani, R Brandt
Cellular and Molecular Life Sciences CMLS 59 (10), 1668-1680, 2002
Conversion of serine to aspartate imitates phosphorylation-induced changes in the structure and function of microtubule-associated protein tau
J Léger, M Kempf, G Lee, R Brandt
Journal of Biological Chemistry 272 (13), 8441-8446, 1997
Divergent pathways mediate spine alterations and cell death induced by amyloid-β, wild-type tau, and R406W tau
C Tackenberg, R Brandt
Journal of Neuroscience 29 (46), 14439-14450, 2009
Structural and functional implications of tau hyperphosphorylation: information from phosphorylation-mimicking mutated tau proteins
J Eidenmüller, T Fath, A Hellwig, J Reed, E Sontag, R Brandt
Biochemistry 39 (43), 13166-13175, 2000
Differential effect of phosphorylation and substrate modulation on tau's ability to promote microtubule growth and nucleation.
R Brandt, G Lee, DB Teplow, D Shalloway, M Abdel-Ghany
Journal of Biological Chemistry 269 (16), 11776-11782, 1994
Phosphorylation-mimicking glutamate clusters in the proline-rich region are sufficient to simulate the functional deficiencies of hyperphosphorylated tau protein
J EIDENMÜLLER, F Thomas, M Thorsten, P Madeline, E SONTAG, ...
Biochemical Journal 357 (3), 759-767, 2001
Insulin-like growth factor 1 inhibits extracellular signal-regulated kinase to promote neuronal survival via the phosphatidylinositol 3-kinase/protein kinase A/c-Raf pathway
S Subramaniam, N Shahani, J Strelau, C Laliberté, R Brandt, D Kaplan, ...
Journal of Neuroscience 25 (11), 2838-2852, 2005
A Caenorhabditis elegans model of tau hyperphosphorylation: Induction of developmental defects by transgenic overexpression of Alzheimer's disease-like …
R Brandt, A Gergou, I Wacker, T Fath, H Hutter
Neurobiology of aging 30 (1), 22-33, 2009
Tau aggregation and progressive neuronal degeneration in the absence of changes in spine density and morphology after targeted expression of Alzheimer's disease-relevant tau …
N Shahani, S Subramaniam, T Wolf, C Tackenberg, R Brandt
Journal of Neuroscience 26 (22), 6103-6114, 2006
The frontotemporal dementia mutation R406W blocks tau’s interaction with the membrane in an annexin A2–dependent manner
A Gauthier-Kemper, C Weissmann, N Golovyashkina, Z Sebö-Lemke, ...
The Journal of cell biology 192 (4), 647-661, 2011
Regulation between O-GlcNAcylation and phosphorylation of neurofilament-M and their dysregulation in Alzheimer disease
Y Deng, B Li, F Liu, K Iqbal, I Grundke-Iqbal, R Brandt, CX Gong
The FASEB Journal 22 (1), 138-145, 2008
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