Miroslaw Cygler
Miroslaw Cygler
Verified email at usask.ca - Homepage
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The α/β hydrolase fold
DL Ollis, E Cheah, M Cygler, B Dijkstra, F Frolow, SM Franken, M Harel, ...
Protein Engineering, Design and Selection 5 (3), 197-211, 1992
Bacillus thuringiensisCrylA (a) insecticidal toxin: crystal structure and channel formation
P Grochulski, L Masson, S Borisova, M Pusztai-Carey, JL Schwartz, ...
Journal of molecular biology 254 (3), 447-464, 1995
Relationship between sequence conservation and three‐dimensional structure in a large family of esterases, lipases, and related proteins
M Cygler, JD Schrag, JL Sussman, M Harel, I Silman, MK Gentry, ...
Protein Science 2 (3), 366-382, 1993
Insights into interfacial activation from an open structure of Candida rugosa lipase.
P Grochulski, Y Li, JD Schrag, F Bouthillier, P Smith, D Harrison, B Rubin, ...
Journal of Biological Chemistry 268 (17), 12843-12847, 1993
Ser-His-Glu triad forms the catalytic site of the lipase from Geotrichum candidum
JD Schrag, Y Li, S Wu, M Cygler
Nature 351 (6329), 761-764, 1991
Two conformational states of Candida rugosa lipase
P Grochulski, Y Li, JD Schrag, M Cygler
Protein Science 3 (1), 82-91, 1994
The structure of calnexin, an ER chaperone involved in quality control of protein folding
JD Schrag, JJM Bergeron, Y Li, S Borisova, M Hahn, DY Thomas, ...
Molecular cell 8 (3), 633-644, 2001
A structural basis for the chiral preferences of lipases
M Cygler, P Grochulski, RJ Kazlauskas, JD Schrag, F Bouthillier, B Rubin, ...
Journal of the American Chemical Society 116 (8), 3180-3186, 1994
Structure of human procathepsin L reveals the molecular basis of inhibition by the prosegment.
R Coulombe, P Grochulski, J Sivaraman, R Menard, JS Mort, M Cygler
The EMBO journal 15 (20), 5492-5503, 1996
The open conformation of a Pseudomonas lipase
JD Schrag, Y Li, M Cygler, D Lang, T Burgdorf, HJ Hecht, R Schmid, ...
Structure 5 (2), 187-202, 1997
[4] Lipases and αβ hydrolase fold
JD Schrag, M Cygler
Methods in enzymology 284, 85-107, 1997
Analogs of reaction intermediates identify a unique substrate binding site in Candida rugosa lipase
P Grochulski, F Bouthillier, RJ Kazlauskas, AN Serreqi, JD Schrag, ...
Biochemistry 33 (12), 3494-3500, 1994
Recognition of a cell-surface oligosaccharide of pathogenic Salmonella by an antibody Fab fragment
M Cygler, DR Rose, DR Bundle
Science 253 (5018), 442-445, 1991
Structure of a calpain Ca 2+-binding domain reveals a novel EF-hand and Ca 2+-induced conformational changes
H Blanchard, P Grochulski, Y Li, JSC Arthur, PL Davies, JS Elce, M Cygler
Nature structural biology 4 (7), 532-538, 1997
Structural basis for Fe–S cluster assembly and tRNA thiolation mediated by IscS protein–protein interactions
R Shi, A Proteau, M Villarroya, I Moukadiri, L Zhang, JF Trempe, A Matte, ...
PLoS Biol 8 (4), e1000354, 2010
Structure of a single-chain antibody variable domain (Fv) fragment complexed with a carbohydrate antigen at 1.7-A resolution
A Zdanov, Y Li, DR Bundle, SJ Deng, CR MacKenzie, SA Narang, ...
Proceedings of the National Academy of Sciences 91 (14), 6423-6427, 1994
Improving tolerance of Candida antarctica lipase B towards irreversible thermal inactivation through directed evolution
N Zhang, WC Suen, W Windsor, L Xiao, V Madison, A Zaks
Protein Engineering 16 (8), 599-605, 2003
Structure of rat procathepsin B: model for inhibition of cysteine protease activity by the proregion
M Cygler, J Sivaraman, P Grochulski, R Coulombe, AC Storer, JS Mort
Structure 4 (4), 405-416, 1996
Lectin control of protein folding and sorting in the secretory pathway
JD Schrag, DO Procopio, M Cygler, DY Thomas, JJM Bergeron
Trends in biochemical sciences 28 (1), 49-57, 2003
Structural and mechanistic classification of uronic acid-containing polysaccharide lyases
ML Garron, M Cygler
Glycobiology 20 (12), 1547-1573, 2010
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