| Complete humanization of the mouse immunoglobulin loci enables efficient therapeutic antibody discovery EC Lee, Q Liang, H Ali, L Bayliss, A Beasley, T Bloomfield-Gerdes, ... Nature biotechnology 32 (4), 356-363, 2014 | 244 | 2014 |
| JAK2 V617F impairs hematopoietic stem cell function in a conditional knock-in mouse model of JAK2 V617F–positive essential thrombocythemia J Li, D Spensberger, JS Ahn, S Anand, PA Beer, C Ghevaert, E Chen, ... Blood, The Journal of the American Society of Hematology 116 (9), 1528-1538, 2010 | 240 | 2010 |
| PTEN regulates PI (3, 4) P2 signaling downstream of class I PI3K M Malek, A Kielkowska, T Chessa, KE Anderson, D Barneda, P Pir, ... Molecular cell 68 (3), 566-580. e10, 2017 | 182 | 2017 |
| ERG promotes T-acute lymphoblastic leukemia and is transcriptionally regulated in leukemic cells by a stem cell enhancer JAI Thoms, Y Birger, S Foster, K Knezevic, Y Kirschenbaum, ... Blood, The Journal of the American Society of Hematology 117 (26), 7079-7089, 2011 | 114 | 2011 |
| Compensation between CSF1R+ macrophages and Foxp3+ Treg cells drives resistance to tumor immunotherapy D Gyori, EL Lim, FM Grant, D Spensberger, R Roychoudhuri, ... JCI insight 3 (11), 2018 | 112 | 2018 |
| An endosiRNA-based repression mechanism counteracts transposon activation during global DNA demethylation in embryonic stem cells RV Berrens, S Andrews, D Spensberger, F Santos, W Dean, P Gould, ... Cell stem cell 21 (5), 694-703. e7, 2017 | 83 | 2017 |
| Somatic heterozygous mutations in ETV6 (TEL) and frequent absence of ETV6 protein in acute myeloid leukemia BW van Doorn-Khosrovani, D Spensberger, Y de Knegt, M Tang, ... Oncogene 24 (25), 4129-4137, 2005 | 70 | 2005 |
| Animal models and therapeutic molecules A Bradley, EC Lee, Q Liang, W Wang, D Spensberger, H Liu, J Clube US Patent 9,253,965, 2016 | 66 | 2016 |
| A novel interaction between the proto-oncogene Evi1 and histone methyltransferases, SUV39H1 and G9a D Spensberger, R Delwel FEBS letters 582 (18), 2761-2767, 2008 | 66 | 2008 |
| Animal models and therapeutic molecules A Bradley, EC Lee, Q Liang, W Wang, D Spensberger, H Liu, J Clube US Patent 9,445,581, 2016 | 62 | 2016 |
| Animal models and therapeutic molecules A Bradley, EC Lee, Q Liang, W Wang, D Spensberger, H Liu, J Clube US Patent 9,788,534, 2017 | 40 | 2017 |
| Genome-wide analysis of transcriptional reprogramming in mouse models of acute myeloid leukaemia N Bonadies, SD Foster, WI Chan, BT Kvinlaug, D Spensberger, ... PloS one 6 (1), e16330, 2011 | 40 | 2011 |
| SETDB1 prevents TET2-dependent activation of IAP retroelements in naïve embryonic stem cells Ö Deniz, L de la Rica, KCL Cheng, D Spensberger, MR Branco Genome biology 19, 1-11, 2018 | 32 | 2018 |
| Animal models and therapeutic molecules A Bradley, EC Lee, Q Liang, W Wang, D Spensberger, H Liu, J Clube US Patent 9,896,516, 2018 | 27 | 2018 |
| Myeloid transforming protein Evi1 interacts with methyl-CpG binding domain protein 3 and inhibits in vitro histone deacetylation by Mbd3/Mi-2/NuRD D Spensberger, M Vermeulen, X Le Guezennec, R Beekman, ... Biochemistry 47 (24), 6418-6426, 2008 | 27 | 2008 |
| Animal models and therapeutic molecules A Bradley, EC Lee, W Wang, Q Liang, D Spensberger, H Liu, J Clube US Patent 9,938,358, 2018 | 26 | 2018 |
| Animal models and therapeutic molecules A Bradley, EC Lee, W Wang, Q Liang, D Spensberger, H Liu, J Clube US Patent 9,938,357, 2018 | 26 | 2018 |
| Animal models and therapeutic molecules Q Liang, A Bradley, EC Lee, W Wang, D Spensberger, H Liu, J Clube US Patent 9,924,705, 2018 | 26 | 2018 |
| Human VpreB & Chimaeric Surrogate Light Chains in Transgenic Non-Human Vertebrates A Bradley, EC Lee, Q Liang, D Spensberger, N England US Patent App. 14/226,706, 2015 | 24 | 2015 |
| ANIMAL MODELS AND THERAPEUTIC MOLECULES-Track 1 A Bradley, EC Lee, Q Liang, W Wang, D Spensberger, H Liu, J Clube US Patent App. 15/369,595, 2017 | 21 | 2017 |
