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Karen O'Rourke
Karen O'Rourke
Verified email at gene.com
Title
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Cited by
Year
FLICE, a novel FADD-homologous ICE/CED-3–like protease, is recruited to the CD95 (Fas/APO-1) death-inducing signaling complex
M Muzio, AM Chinnaiyan, FC Kischkel, K O'Rourke, A Shevchenko, J Ni, ...
Cell 85 (6), 817-827, 1996
39591996
Cryopyrin activates the inflammasome in response to toxins and ATP
S Mariathasan, DS Weiss, K Newton, J McBride, K O'Rourke, ...
Nature 440 (7081), 228-232, 2006
34382006
FADD, a novel death domain-containing protein, interacts with the death domain of Fas and initiates apoptosis
AM Chinnaiyan, K O'Rourke, M Tewari, VM Dixit
Cell 81 (4), 505-512, 1995
34341995
Caspase-11 cleaves gasdermin D for non-canonical inflammasome signalling
N Kayagaki, IB Stowe, BL Lee, K O’Rourke, K Anderson, S Warming, ...
Nature 526 (7575), 666-671, 2015
30082015
Yama/CPP32β, a mammalian homolog of CED-3, is a CrmA-inhibitable protease that cleaves the death substrate poly (ADP-ribose) polymerase
M Tewari, LT Quan, K O'Rourke, S Desnoyers, Z Zeng, DR Beidler, ...
Cell 81 (5), 801-809, 1995
29881995
The receptor for the cytotoxic ligand TRAIL
G Pan, K O'Rourke, AM Chinnaiyan, R Gentz, R Ebner, J Ni, VM Dixit
Science 276 (5309), 111-113, 1997
24211997
De-ubiquitination and ubiquitin ligase domains of A20 downregulate NF-κB signalling
IE Wertz, KM O'rourke, H Zhou, M Eby, L Aravind, S Seshagiri, P Wu, ...
Nature 430 (7000), 694-699, 2004
21642004
Identification of paracaspases and metacaspases: two ancient families of caspase-like proteins, one of which plays a key role in MALT lymphoma
AG Uren, K O'Rourke, LA Aravind, MT Pisabarro, S Seshagiri, EV Koonin, ...
Molecular cell 6 (4), 961-967, 2000
13142000
FADD/MORT1 Is a Common Mediator of CD95 (Fas/APO-1) and Tumor Necrosis Factor Receptor-induced Apoptosis (∗)
AM Chinnaiyan, CG Tepper, MF Seldin, K O'Rourke, FC Kischkel, ...
Journal of Biological Chemistry 271 (9), 4961-4965, 1996
10661996
Interaction of CED-4 with CED-3 and CED-9: a molecular framework for cell death
AM Chinnaiyan, K O'Rourke, BR Lane, VM Dixit
Science 275 (5303), 1122-1126, 1997
9461997
The ubiquitin ligase COP1 is a critical negative regulator of p53
D Dornan, I Wertz, H Shimizu, D Arnott, GD Frantz, P Dowd, K O'Rourke, ...
Nature 429 (6987), 86-92, 2004
9032004
Signal transduction by DR3, a death domain-containing receptor related to TNFR-1 and CD95
AM Chinnaiyan, K O'Rourke, GL Yu, RH Lyons, M Garg, DR Duan, L Xing, ...
Science 274 (5289), 990-992, 1996
8771996
Sensitivity to antitubulin chemotherapeutics is regulated by MCL1 and FBW7
IE Wertz, S Kusam, C Lam, T Okamoto, W Sandoval, DJ Anderson, ...
Nature 471 (7336), 110-114, 2011
8522011
Caspase-9, Bcl-XL, and Apaf-1 form a ternary complex
G Pan, K O'Rourke, VM Dixit
Journal of Biological Chemistry 273 (10), 5841-5845, 1998
8141998
Molecular Ordering of the Cell Death Pathway: Bcl-2 AND Bcl-xL Function upstream of the CED-3-like apoptotic proteases (∗)
AM Chinnaiyan, K Orth, K O'Rourke, H Duan, GG Poirier, VM Dixit
Journal of Biological Chemistry 271 (9), 4573-4576, 1996
7651996
Deubiquitinase USP9X stabilizes MCL1 and promotes tumour cell survival
M Schwickart, XD Huang, JR Lill, J Liu, R Ferrando, DM French, ...
Nature 463 (7277), 103-107, 2010
7182010
Bcl10 activates the NF-κB pathway through ubiquitination of NEMO
H Zhou, I Wertz, K O'Rourke, M Ultsch, S Seshagiri, M Eby, W Xiao, ...
Nature 427 (6970), 167-171, 2004
6822004
Absent in melanoma 2 is required for innate immune recognition of Francisella tularensis
JW Jones, N Kayagaki, P Broz, T Henry, K Newton, K O'Rourke, S Chan, ...
Proceedings of the National Academy of Sciences 107 (21), 9771-9776, 2010
5722010
A deubiquitinase that regulates type I interferon production
N Kayagaki, Q Phung, S Chan, R Chaudhari, C Quan, KM O'Rourke, ...
Science 318 (5856), 1628-1632, 2007
5222007
Tumor necrosis factor-alpha induction of novel gene products in human endothelial cells including a macrophage-specific chemotaxin.
VM Dixit, S Green, V Sarma, LB Holzman, FW Wolf, K O'Rourke, PA Ward, ...
Journal of Biological Chemistry 265 (5), 2973-2978, 1990
4971990
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