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John J. Renger, Ph.D.
John J. Renger, Ph.D.
Cerevel Therapeutics
Verified email at cerevel.com
Title
Cited by
Cited by
Year
Improved stability of Drosophila larval neuromuscular preparations in haemolymph-like physiological solutions
BA Stewart, HL Atwood, JJ Renger, J Wang, CF Wu
Journal of Comparative Physiology A 175, 179-191, 1994
8531994
Discovery of the Dual Orexin Receptor Antagonist [(7R)-4-(5-Chloro-1,3-benzoxazol-2-yl)-7-methyl-1,4-diazepan-1-yl][5-methyl-2-(2H-1,2,3-triazol-2-yl)phenyl …
CD Cox, MJ Breslin, DB Whitman, JD Schreier, GB McGaughey, ...
Journal of medicinal chemistry 53 (14), 5320-5332, 2010
4002010
Promotion of sleep by suvorexant—a novel dual orexin receptor antagonist
CJ Winrow, AL Gotter, CD Cox, SM Doran, PL Tannenbaum, MJ Breslin, ...
Journal of neurogenetics 25 (1-2), 52-61, 2011
2782011
A developmental switch in neurotransmitter flux enhances synaptic efficacy by affecting AMPA receptor activation
JJ Renger, C Egles, G Liu
Neuron 29 (2), 469-484, 2001
2572001
Essential thalamic contribution to slow waves of natural sleep
F David, JT Schmiedt, HL Taylor, G Orban, G Di Giovanni, VN Uebele, ...
Journal of Neuroscience 33 (50), 19599-19610, 2013
2232013
Selective T-type calcium channel block in thalamic neurons reveals channel redundancy and physiological impact of ITwindow
FM Dreyfus, A Tscherter, AC Errington, JJ Renger, HS Shin, VN Uebele, ...
Journal of Neuroscience 30 (1), 99-109, 2010
2212010
Internalized tau oligomers cause neurodegeneration by inducing accumulation of pathogenic tau in human neurons derived from induced pluripotent stem cells
M Usenovic, S Niroomand, RE Drolet, L Yao, RC Gaspar, NG Hatcher, ...
Journal of Neuroscience 35 (42), 14234-14250, 2015
2122015
Presynaptic HCN1 channels regulate CaV3.2 activity and neurotransmission at select cortical synapses
Z Huang, R Lujan, I Kadurin, VN Uebele, JJ Renger, AC Dolphin, ...
Nature neuroscience 14 (4), 478-486, 2011
2002011
Presynaptic Cav3. 2 channels regulate excitatory neurotransmission in nociceptive dorsal horn neurons
MO Jacus, VN Uebele, JJ Renger, SM Todorovic
Journal of Neuroscience 32 (27), 9374-9382, 2012
1832012
International Union of Basic and Clinical Pharmacology. LXXXVI. Orexin receptor function, nomenclature and pharmacology
AL Gotter, AL Webber, PJ Coleman, JJ Renger, CJ Winrow
Pharmacological reviews 64 (3), 389-420, 2012
1812012
A sensitive aβ oligomer assay discriminates Alzheimer's and aged control cerebrospinal fluid
MJ Savage, J Kalinina, A Wolfe, K Tugusheva, R Korn, T Cash-Mason, ...
Journal of Neuroscience 34 (8), 2884-2897, 2014
1632014
Discovery and development of orexin receptor antagonists as therapeutics for insomnia
CJ Winrow, JJ Renger
British journal of pharmacology 171 (2), 283-293, 2014
1572014
Pharmacological characterization of MK-6096–a dual orexin receptor antagonist for insomnia
CJ Winrow, AL Gotter, CD Cox, PL Tannenbaum, SL Garson, SM Doran, ...
Neuropharmacology 62 (2), 978-987, 2012
1532012
Design, Synthesis, and Evaluation of a Novel 4-Aminomethyl-4-fluoropiperidine as a T-Type Ca2+ Channel Antagonist
WD Shipe, JC Barrow, ZQ Yang, CW Lindsley, FV Yang, KAS Schlegel, ...
Journal of medicinal chemistry 51 (13), 3692-3695, 2008
1402008
Structure and ligand-binding mechanism of the human OX1 and OX2 orexin receptors
J Yin, K Babaoglu, CA Brautigam, L Clark, Z Shao, TH Scheuermann, ...
Nature Structural & Molecular Biology 23 (4), 293-299, 2016
1372016
Discovery of [(2R,5R)‐5‐{[(5‐Fluoropyridin‐2‐yl)oxy]methyl}‐2‐methylpiperidin‐1‐yl][5‐methyl‐2‐(pyrimidin‐2‐yl)phenyl]methanone (MK‐6096): A Dual Orexin …
PJ Coleman, JD Schreier, CD Cox, MJ Breslin, DB Whitman, MJ Bogusky, ...
ChemMedChem 7 (3), 415-424, 2012
1332012
Concomitant alterations of physiological and developmental plasticity in Drosophila CaM kinase II-inhibited synapses
J Wang, JI Renger, LC Griffith, RJ Greenspan, CF Wu
Neuron 13 (6), 1373-1384, 1994
1331994
Calcineurin signaling mediates activity-dependent relocation of the axon initial segment
MD Evans, RP Sammons, S Lebron, AS Dumitrescu, TBK Watkins, ...
Journal of Neuroscience 33 (16), 6950-6963, 2013
1292013
Orexin receptor antagonism prevents transcriptional and behavioral plasticity resulting from stimulant exposure
CJ Winrow, KQ Tanis, DR Reiss, AM Rigby, JM Uslaner, VN Uebele, ...
Neuropharmacology 58 (1), 185-194, 2010
1262010
In vitro characterization of T-type calcium channel antagonist TTA-A2 and in vivo effects on arousal in mice
RL Kraus, Y Li, Y Gregan, AL Gotter, VN Uebele, SV Fox, SM Doran, ...
Journal of Pharmacology and Experimental Therapeutics 335 (2), 409-417, 2010
1252010
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