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Justin Pritchard
Justin Pritchard
Verified email at psu.edu
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Year
A subset of platinum-containing chemotherapeutic agents kills cells by inducing ribosome biogenesis stress
PM Bruno, Y Liu, GY Park, J Murai, CE Koch, TJ Eisen, JR Pritchard, ...
Nature medicine 23 (4), 461-471, 2017
4922017
Programmable transcriptional repression in mycobacteria using an orthogonal CRISPR interference platform
JM Rock, FF Hopkins, A Chavez, M Diallo, MR Chase, ER Gerrick, ...
Nature microbiology 2 (4), 1-9, 2017
4882017
Defining principles of combination drug mechanisms of action
JR Pritchard, PM Bruno, LA Gilbert, KL Capron, DA Lauffenburger, ...
Proceedings of the National Academy of Sciences 110 (2), E170-E179, 2013
1872013
ARTIST: high-resolution genome-wide assessment of fitness using transposon-insertion sequencing
JR Pritchard, MC Chao, S Abel, BM Davis, C Baranowski, YJ Zhang, ...
PLoS genetics 10 (11), e1004782, 2014
1662014
The primary mechanism of cytotoxicity of the chemotherapeutic agent CX-5461 is topoisomerase II poisoning
PM Bruno, M Lu, KA Dennis, H Inam, CJ Moore, J Sheehe, SJ Elledge, ...
Proceedings of the National Academy of Sciences 117 (8), 4053-4060, 2020
1452020
High-resolution definition of the Vibrio cholerae essential gene set with hidden Markov model–based analyses of transposon-insertion sequencing data
MC Chao, JR Pritchard, YJ Zhang, EJ Rubin, J Livny, BM Davis, ...
Nucleic acids research 41 (19), 9033-9048, 2013
1452013
Exploiting temporal collateral sensitivity in tumor clonal evolution
B Zhao, JC Sedlak, R Srinivas, P Creixell, JR Pritchard, B Tidor, ...
Cell 165 (1), 234-246, 2016
1442016
Addressing genetic tumor heterogeneity through computationally predictive combination therapy
B Zhao, JR Pritchard, DA Lauffenburger, MT Hemann
Cancer discovery 4 (2), 166-174, 2014
1152014
Identification of genes required for Mycobacterium abscessus growth in vivo with a prominent role of the ESX-4 locus
L Laencina, V Dubois, V Le Moigne, A Viljoen, L Majlessi, J Pritchard, ...
Proceedings of the National Academy of Sciences 115 (5), E1002-E1011, 2018
1132018
A mammalian functional-genetic approach to characterizing cancer therapeutics
H Jiang, JR Pritchard, RT Williams, DA Lauffenburger, MT Hemann
Nature chemical biology 7 (2), 92-100, 2011
1082011
Understanding resistance to combination chemotherapy
JR Pritchard, DA Lauffenburger, MT Hemann
Drug Resistance Updates 15 (5-6), 249-257, 2012
1042012
An inducible autocrine cascade regulates rat hepatocyte proliferation and apoptosis responses to tumor necrosis factor‐α
BD Cosgrove, C Cheng, JR Pritchard, DB Stolz, DA Lauffenburger, ...
Hepatology 48 (1), 276-288, 2008
912008
Acquisition of a single EZH2 D1 domain mutation confers acquired resistance to EZH2-targeted inhibitors
T Baker, S Nerle, J Pritchard, B Zhao, VM Rivera, A Garner, F Gonzalvez
Oncotarget 6 (32), 32646, 2015
772015
A genome-scale in vivo loss-of-function screen identifies Phf6 as a lineage-specific regulator of leukemia cell growth
CE Meacham, LN Lawton, YM Soto-Feliciano, JR Pritchard, BA Joughin, ...
Genes & development 29 (5), 483-488, 2015
742015
Multiple screening approaches reveal HDAC6 as a novel regulator of glycolytic metabolism in triple-negative breast cancer
CM Dowling, KER Hollinshead, A Di Grande, J Pritchard, H Zhang, ...
Science Advances 7 (3), eabc4897, 2021
492021
Single-molecule sequencing reveals patterns of preexisting drug resistance that suggest treatment strategies in Philadelphia-positive leukemias
MW Schmitt, JR Pritchard, SM Leighow, BI Aminov, L Beppu, DS Kim, ...
Clinical Cancer Research 24 (21), 5321-5334, 2018
392018
Predicting cancer drug mechanisms of action using molecular network signatures
JR Pritchard, PM Bruno, MT Hemann, DA Lauffenburger
Molecular BioSystems 9 (7), 1604-1619, 2013
372013
Optimal SARS-CoV-2 vaccine allocation using real-time attack-rate estimates in Rhode Island and Massachusetts
TNA Tran, NB Wikle, E Albert, H Inam, E Strong, K Brinda, SM Leighow, ...
BMC medicine 19, 1-14, 2021
322021
Ultra-accurate Duplex Sequencing for the assessment of pretreatment ABL1 kinase domain mutations in Ph+ ALL
NJ Short, H Kantarjian, R Kanagal-Shamanna, K Sasaki, F Ravandi, ...
Blood cancer journal 10 (5), 61, 2020
312020
RET fusions observed in lung and colorectal cancers are sensitive to ponatinib
JM Gozgit, TH Chen, Y Song, S Wardwell, F Wang, J Cai, H Li, H Edgren, ...
Oncotarget 9 (51), 29654, 2018
302018
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