A liquid-to-solid phase transition of the ALS protein FUS accelerated by disease mutation A Patel, HO Lee, L Jawerth, S Maharana, M Jahnel, MY Hein, S Stoynov, ... Cell 162 (5), 1066-1077, 2015 | 2726 | 2015 |
Some like it hot: the structure and function of small heat-shock proteins M Haslbeck, T Franzmann, D Weinfurtner, J Buchner Nature structural & molecular biology 12 (10), 842-846, 2005 | 1067 | 2005 |
RNA buffers the phase separation behavior of prion-like RNA binding proteins S Maharana, J Wang, DK Papadopoulos, D Richter, A Pozniakovsky, ... Science 360 (6391), 918-921, 2018 | 1000 | 2018 |
RNA-induced conformational switching and clustering of G3BP drive stress granule assembly by condensation J Guillén-Boixet, A Kopach, AS Holehouse, S Wittmann, M Jahnel, ... Cell 181 (2), 346-361. e17, 2020 | 682 | 2020 |
Phase separation of a yeast prion protein promotes cellular fitness TM Franzmann, M Jahnel, A Pozniakovsky, J Mahamid, AS Holehouse, ... Science 359 (6371), eaao5654, 2018 | 669 | 2018 |
A pH-driven transition of the cytoplasm from a fluid-to a solid-like state promotes entry into dormancy MC Munder, D Midtvedt, T Franzmann, E Nuske, O Otto, M Herbig, ... elife 5, e09347, 2016 | 454 | 2016 |
An aberrant phase transition of stress granules triggered by misfolded protein and prevented by chaperone function D Mateju, TM Franzmann, A Patel, A Kopach, EE Boczek, S Maharana, ... The EMBO journal 36 (12), 1669-1687, 2017 | 452 | 2017 |
Reentrant liquid condensate phase of proteins is stabilized by hydrophobic and non-ionic interactions G Krainer, TJ Welsh, JA Joseph, P St George-Hyslop, AA Hyman, ... Biophysical Journal 120 (3), 28a, 2021 | 375 | 2021 |
Protein condensates as aging Maxwell fluids L Jawerth, E Fischer-Friedrich, S Saha, J Wang, T Franzmann, X Zhang, ... Science 370 (6522), 1317-1323, 2020 | 344 | 2020 |
A user’s guide for phase separation assays with purified proteins S Alberti, S Saha, JB Woodruff, TM Franzmann, J Wang, AA Hyman Journal of molecular biology 430 (23), 4806-4820, 2018 | 264 | 2018 |
Different material states of Pub1 condensates define distinct modes of stress adaptation and recovery S Kroschwald, MC Munder, S Maharana, TM Franzmann, D Richter, ... Cell reports 23 (11), 3327-3339, 2018 | 223 | 2018 |
Prion-like low-complexity sequences: Key regulators of protein solubility and phase behavior TM Franzmann, S Alberti Journal of Biological Chemistry 294 (18), 7128-7136, 2019 | 221 | 2019 |
Condensation of Ded1p promotes a translational switch from housekeeping to stress protein production C Iserman, CD Altamirano, C Jegers, U Friedrich, T Zarin, AW Fritsch, ... Cell 181 (4), 818-831. e19, 2020 | 191 | 2020 |
The eye lens chaperone α-crystallin forms defined globular assemblies J Peschek, N Braun, TM Franzmann, Y Georgalis, M Haslbeck, ... Proceedings of the National Academy of Sciences 106 (32), 13272-13277, 2009 | 180 | 2009 |
Phase-separating RNA-binding proteins form heterogeneous distributions of clusters in subsaturated solutions M Kar, F Dar, TJ Welsh, LT Vogel, R Kühnemuth, A Majumdar, G Krainer, ... Proceedings of the National Academy of Sciences 119 (28), e2202222119, 2022 | 178 | 2022 |
Protein phase separation as a stress survival strategy TM Franzmann, S Alberti Cold Spring Harbor perspectives in biology 11 (6), a034058, 2019 | 143 | 2019 |
Multiple distinct assemblies reveal conformational flexibility in the small heat shock protein Hsp26 HE White, EV Orlova, S Chen, L Wang, A Ignatiou, B Gowen, T Stromer, ... Structure 14 (7), 1197-1204, 2006 | 121 | 2006 |
Activation of the chaperone Hsp26 is controlled by the rearrangement of its thermosensor domain TM Franzmann, P Menhorn, S Walter, J Buchner Molecular cell 29 (2), 207-216, 2008 | 117 | 2008 |
Protein refolding by pH-triggered chaperone binding and release TL Tapley, TM Franzmann, S Chakraborty, U Jakob, JCA Bardwell Proceedings of the national Academy of Sciences 107 (3), 1071-1076, 2010 | 110 | 2010 |
The activation mechanism of Hsp26 does not require dissociation of the oligomer TM Franzmann, M Wühr, K Richter, S Walter, J Buchner Journal of molecular biology 350 (5), 1083-1093, 2005 | 108 | 2005 |