| Reversal of diabetes with insulin-producing cells derived in vitro from human pluripotent stem cells A Rezania, JE Bruin, P Arora, A Rubin, I Batushansky, A Asadi, S O'dwyer, ... Nature biotechnology 32 (11), 1121-1133, 2014 | 1585 | 2014 |
| Maturation of human embryonic stem cell–derived pancreatic progenitors into functional islets capable of treating pre-existing diabetes in mice A Rezania, JE Bruin, MJ Riedel, M Mojibian, A Asadi, J Xu, R Gauvin, ... Diabetes 61 (8), 2016-2029, 2012 | 688 | 2012 |
| Long-term consequences of fetal and neonatal nicotine exposure: a critical review JE Bruin, HC Gerstein, AC Holloway Toxicological sciences 116 (2), 364-374, 2010 | 450 | 2010 |
| Enrichment of human embryonic stem cell-derived NKX6. 1-expressing pancreatic progenitor cells accelerates the maturation of insulin-secreting cells in vivo A Rezania, JE Bruin, J Xu, K Narayan, JK Fox, JJ O'Neil, TJ Kieffer Stem cells 31 (11), 2432-2442, 2013 | 313 | 2013 |
| Maturation and function of human embryonic stem cell-derived pancreatic progenitors in macroencapsulation devices following transplant into mice JE Bruin, A Rezania, J Xu, K Narayan, JK Fox, JJ O’Neil, TJ Kieffer Diabetologia 56, 1987-1998, 2013 | 235 | 2013 |
| Reduced insulin production relieves endoplasmic reticulum stress and induces β cell proliferation M Szabat, MM Page, E Panzhinskiy, S Skovsø, M Mojibian, ... Cell metabolism 23 (1), 179-193, 2016 | 202 | 2016 |
| Characterization of polyhormonal insulin-producing cells derived in vitro from human embryonic stem cells JE Bruin, S Erener, J Vela, X Hu, JD Johnson, HT Kurata, FC Lynn, ... Stem cell research 12 (1), 194-208, 2014 | 166 | 2014 |
| Fetal and neonatal nicotine exposure and postnatal glucose homeostasis: identifying critical windows of exposure JE Bruin, LD Kellenberger, HC Gerstein, KM Morrison, AC Holloway Journal of Endocrinology 194 (1), 171-178, 2007 | 112 | 2007 |
| Fetal and neonatal nicotine exposure in Wistar rats causes progressive pancreatic mitochondrial damage and beta cell dysfunction JE Bruin, MA Petre, S Raha, KM Morrison, HC Gerstein, AC Holloway PloS one 3 (10), e3371, 2008 | 108 | 2008 |
| Maternal nicotine exposure increases oxidative stress in the offspring JE Bruin, MA Petre, MA Lehman, S Raha, HC Gerstein, KM Morrison, ... Free Radical Biology and Medicine 44 (11), 1919-1925, 2008 | 108 | 2008 |
| Increased pancreatic beta-cell apoptosis following fetal and neonatal exposure to nicotine is mediated via the mitochondria JE Bruin, HC Gerstein, KM Morrison, AC Holloway Toxicological Sciences 103 (2), 362-370, 2008 | 103 | 2008 |
| Treating diet-induced diabetes and obesity with human embryonic stem cell-derived pancreatic progenitor cells and antidiabetic drugs JE Bruin, N Saber, N Braun, JK Fox, M Mojibian, A Asadi, C Drohan, ... Stem cell reports 4 (4), 605-620, 2015 | 100 | 2015 |
| Accelerated maturation of human stem cell-derived pancreatic progenitor cells into insulin-secreting cells in immunodeficient rats relative to mice JE Bruin, A Asadi, JK Fox, S Erener, A Rezania, TJ Kieffer Stem cell reports 5 (6), 1081-1096, 2015 | 83 | 2015 |
| The role of dysregulated glucose metabolism in epithelial ovarian cancer LD Kellenberger, JE Bruin, J Greenaway, NE Campbell, RA Moorehead, ... Journal of oncology 2010, 2010 | 65 | 2010 |
| Differentiation of human pluripotent stem cells into β-cells: Potential and challenges N Quiskamp, JE Bruin, TJ Kieffer Best Practice & research Clinical endocrinology & metabolism 29 (6), 833-847, 2015 | 54 | 2015 |
| Replacing and safeguarding pancreatic β cells for diabetes JE Bruin, A Rezania, TJ Kieffer Science translational medicine 7 (316), 316ps23-316ps23, 2015 | 51 | 2015 |
| Sex Differences in Maturation of Human Embryonic Stem Cell–Derived β Cells in Mice N Saber, JE Bruin, S O’Dwyer, H Schuster, A Rezania, TJ Kieffer Endocrinology 159 (4), 1827-1841, 2018 | 48 | 2018 |
| Implanted islets in the anterior chamber of the eye are prone to autoimmune attack in a mouse model of diabetes M Mojibian, B Harder, A Hurlburt, JE Bruin, A Asadi, TJ Kieffer Diabetologia 56, 2213-2221, 2013 | 47 | 2013 |
| Functional cytochrome P450 1A enzymes are induced in mouse and human islets following pollutant exposure M Ibrahim, EM MacFarlane, G Matteo, MP Hoyeck, KRC Rick, S Farokhi, ... Diabetologia 63, 162-178, 2020 | 46 | 2020 |
| Hypothyroidism impairs human stem cell–derived pancreatic progenitor cell maturation in mice JE Bruin, N Saber, S O’Dwyer, JK Fox, M Mojibian, P Arora, A Rezania, ... Diabetes 65 (5), 1297-1309, 2016 | 41 | 2016 |
Timothy J KiefferProfessor, University of British ColumbiaVerified email at ubc.ca
