Douglas E Befroy
Douglas E Befroy
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Impaired mitochondrial activity in the insulin-resistant offspring of patients with type 2 diabetes
KF Petersen, S Dufour, D Befroy, R Garcia, GI Shulman
New England Journal of Medicine 350 (7), 664-671, 2004
Mitochondrial dysfunction in the elderly: possible role in insulin resistance
KF Petersen, D Befroy, S Dufour, J Dziura, C Ariyan, DL Rothman, ...
Science 300 (5622), 1140-1142, 2003
Mechanism of hepatic insulin resistance in non-alcoholic fatty liver disease
VT Samuel, ZX Liu, X Qu, BD Elder, S Bilz, D Befroy, AJ Romanelli, ...
Journal of Biological Chemistry 279 (31), 32345-32353, 2004
Reversal of nonalcoholic hepatic steatosis, hepatic insulin resistance, and hyperglycemia by moderate weight reduction in patients with type 2 diabetes
KF Petersen, S Dufour, D Befroy, M Lehrke, RE Hendler, GI Shulman
Diabetes 54 (3), 603-608, 2005
Reduced mitochondrial density and increased IRS-1 serine phosphorylation in muscle of insulin-resistant offspring of type 2 diabetic parents
K Morino, KF Petersen, S Dufour, D Befroy, J Frattini, N Shatzkes, ...
The Journal of clinical investigation 115 (12), 3587-3593, 2005
Leptin reverses insulin resistance and hepatic steatosis in patients with severe lipodystrophy
KF Petersen, EA Oral, S Dufour, D Befroy, C Ariyan, C Yu, GW Cline, ...
The Journal of clinical investigation 109 (10), 1345-1350, 2002
The effects of rosiglitazone on insulin sensitivity, lipolysis, and hepatic and skeletal muscle triglyceride content in patients with type 2 diabetes
AB Mayerson, RS Hundal, S Dufour, V Lebon, D Befroy, GW Cline, ...
Diabetes 51 (3), 797-802, 2002
The role of skeletal muscle insulin resistance in the pathogenesis of the metabolic syndrome
KF Petersen, S Dufour, DB Savage, S Bilz, G Solomon, S Yonemitsu, ...
Proceedings of the National Academy of Sciences 104 (31), 12587-12594, 2007
Aging-associated reductions in AMP-activated protein kinase activity and mitochondrial biogenesis
RM Reznick, H Zong, J Li, K Morino, IK Moore, JY Hannah, ZX Liu, J Dong, ...
Cell metabolism 5 (2), 151-156, 2007
Impaired mitochondrial substrate oxidation in muscle of insulin-resistant offspring of type 2 diabetic patients
DE Befroy, KF Petersen, S Dufour, GF Mason, RA de Graaf, DL Rothman, ...
Diabetes 56 (5), 1376-1381, 2007
Increased prevalence of insulin resistance and nonalcoholic fatty liver disease in Asian-Indian men
KF Petersen, S Dufour, J Feng, D Befroy, J Dziura, C Dalla Man, C Cobelli, ...
Proceedings of the National Academy of Sciences 103 (48), 18273-18277, 2006
Paradoxical effects of increased expression of PGC-1α on muscle mitochondrial function and insulin-stimulated muscle glucose metabolism
CS Choi, DE Befroy, R Codella, S Kim, RM Reznick, YJ Hwang, ZX Liu, ...
Proceedings of the National Academy of Sciences 105 (50), 19926-19931, 2008
Comparative MR study of hepatic fat quantification using single‐voxel proton spectroscopy, two‐point dixon and three‐point IDEAL
H Kim, SE Taksali, S Dufour, D Befroy, TR Goodman, KF Petersen, ...
Magnetic Resonance in Medicine: An Official Journal of the International …, 2008
Age-related changes in ATP-producing pathways in human skeletal muscle in vivo
IR Lanza, DE Befroy, JA Kent-Braun
Journal of applied physiology 99 (5), 1736-1744, 2005
Increased substrate oxidation and mitochondrial uncoupling in skeletal muscle of endurance-trained individuals
DE Befroy, KF Petersen, S Dufour, GF Mason, DL Rothman, GI Shulman
Proceedings of the National Academy of Sciences 105 (43), 16701-16706, 2008
Resistance to thyroid hormone is associated with raised energy expenditure, muscle mitochondrial uncoupling, and hyperphagia
CS Mitchell, DB Savage, S Dufour, N Schoenmakers, P Murgatroyd, ...
The Journal of clinical investigation 120 (4), 1345-1354, 2010
A randomized controlled study of effects of dietary magnesium oxide supplementation on bone mineral content in healthy girls
TO Carpenter, MC DeLucia, JH Zhang, G Bejnerowicz, L Tartamella, ...
The Journal of Clinical Endocrinology & Metabolism 91 (12), 4866-4872, 2006
In vivo ATP production during free‐flow and ischaemic muscle contractions in humans
IR Lanza, DM Wigmore, DE Befroy, JA Kent‐Braun
The Journal of physiology 577 (1), 353-367, 2006
Direct assessment of hepatic mitochondrial oxidative and anaplerotic fluxes in humans using dynamic 13 C magnetic resonance spectroscopy
DE Befroy, RJ Perry, N Jain, S Dufour, GW Cline, JK Trimmer, J Brosnan, ...
Nature medicine 20 (1), 98-102, 2014
31P-magnetization transfer magnetic resonance spectroscopy measurements of in vivo metabolism
DE Befroy, DL Rothman, KF Petersen, GI Shulman
Diabetes 61 (11), 2669-2678, 2012
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