The architecture of the spliceosomal U4/U6. U5 tri-snRNP THD Nguyen, WP Galej, XC Bai, CG Savva, AJ Newman, SH Scheres, ... Nature 523 (7558), 47-52, 2015 | 244 | 2015 |
Cryo-EM structure of substrate-bound human telomerase holoenzyme THD Nguyen, J Tam, RA Wu, BJ Greber, D Toso, E Nogales, K Collins Nature 557 (7704), 190-195, 2018 | 234 | 2018 |
Cryo-EM structure of the yeast U4/U6.U5 tri-snRNP at 3.7 Å resolution THD Nguyen, WP Galej, XC Bai, O C, AJ Newman, SH Scheres, K Nagai Nature, 2016 | 224 | 2016 |
Binding of low molecular weight inhibitors promotes large conformational changes in the dengue virus NS2B-NS3 protease: fold analysis by pseudocontact shifts L de la Cruz, THD Nguyen, K Ozawa, J Shin, B Graham, T Huber, G Otting Journal of the American Chemical Society 133 (47), 19205-19215, 2011 | 137 | 2011 |
Structure of human telomerase holoenzyme with bound telomeric DNA GE Ghanim, AJ Fountain, AMM Van Roon, R Rangan, R Das, K Collins, ... Nature 593 (7859), 449-453, 2021 | 125 | 2021 |
The cryo-electron microscopy structure of human transcription factor IIH BJ Greber, THD Nguyen, J Fang, PV Afonine, PD Adams, E Nogales Nature 549 (7672), 414-417, 2017 | 108 | 2017 |
Structural basis of Brr2-Prp8 interactions and implications for U5 snRNP biogenesis and the spliceosome active site THD Nguyen, J Li, WP Galej, H Oshikane, AJ Newman, K Nagai Structure 21 (6), 910-919, 2013 | 93 | 2013 |
Substrate-promoted formation of a catalytically competent binuclear center and regulation of reactivity in a glycerophosphodiesterase from Enterobacter aerogenes. SG 8. Hadler KS, Tanifum EA, Yip SH-C, Mitić N, Guddat LW, Jackson CJ, Gahan ... Journal of American Chemical Society 130, 14129-14138, 2008 | 86 | 2008 |
Structural mechanism of ATP-independent transcription initiation by RNA polymerase I Y Han, C Yan, THD Nguyen, AJ Jackobel, I Ivanov, BA Knutson, Y He Elife 6, e27414, 2017 | 72 | 2017 |
Structural studies of the spliceosome: zooming into the heart of the machine WP Galej, THD Nguyen, AJ Newman, K Nagai Current opinion in structural biology 25, 57-66, 2014 | 66 | 2014 |
CryoEM structures of two spliceosomal complexes: starter and dessert at the spliceosome feast THD Nguyen, WP Galej, SM Fica, PC Lin, AJ Newman, K Nagai Current opinion in structural biology 36, 48-57, 2016 | 64 | 2016 |
A bis-carbyne (ethanediylidyne) complex via the catalytic demercuration of a mercury bis (carbido) complex AL Colebatch, RL Cordiner, AF Hill, KTHD Nguyen, R Shang, AC Willis Organometallics 28 (15), 4394-4399, 2009 | 62 | 2009 |
Structural basis of human telomerase recruitment by TPP1-POT1 Z Sekne, GE Ghanim, AMM Van Roon, THD Nguyen Science 375 (6585), 1173-1176, 2022 | 53 | 2022 |
Generation of pseudocontact shifts in protein NMR spectra with a genetically encoded cobalt (II)‐binding amino acid THD Nguyen, K Ozawa, M Stanton‐Cook, R Barrow, T Huber, G Otting Angewandte Chemie 123 (3), 718-720, 2011 | 46 | 2011 |
Telomerase structures and regulation: shedding light on the chromosome end THD Nguyen, K Collins, E Nogales Current opinion in structural biology 55, 185-193, 2019 | 19 | 2019 |
Structure of the endosomal Commander complex linked to Ritscher-Schinzel syndrome MD Healy, KE McNally, R Butkovič, M Chilton, K Kato, J Sacharz, ... Cell 186 (10), 2219-2237. e29, 2023 | 16 | 2023 |
THD; Shang, R.; Willis, AC AF Hill, AL Colebatch, RL Cordiner, RD Dewhurst, CAM McQueen, ... Comments Inorg. Chem 31, 121-129, 2010 | 11 | 2010 |
Structural biology of human telomerase: progress and prospects THD Nguyen Biochemical Society Transactions 49 (5), 1927-1939, 2021 | 10 | 2021 |
Structural mechanism of ATP-independent transcription initiation by RNA polymerase I. Elife 6 Y Han, C Yan, THD Nguyen, AJ Jackobel, I Ivanov, BA Knutson, Y He | 8 | 2017 |
Structural basis of telomeric nucleosome recognition by shelterin factor TRF1 H Hu, AMM van Roon, GE Ghanim, B Ahsan, AO Oluwole, SY Peak-Chew, ... Science Advances 9 (34), eadi4148, 2023 | 4 | 2023 |