Colin Dunstan
Colin Dunstan
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Osteoprotegerin ligand is a cytokine that regulates osteoclast differentiation and activation
DL Lacey, E Timms, HL Tan, MJ Kelley, CR Dunstan, T Burgess, R Elliott, ...
cell 93 (2), 165-176, 1998
Osteoprotegerin: a novel secreted protein involved in the regulation of bone density
WS Simonet, DL Lacey, CR Dunstan, M Kelley, MS Chang, R Lüthy, ...
Cell 89 (2), 309-319, 1997
OPGL is a key regulator of osteoclastogenesis, lymphocyte development and lymph-node organogenesis
YY Kong, H Yoshida, I Sarosi, HL Tan, E Timms, C Capparelli, S Morony, ...
Nature 397 (6717), 315-323, 1999
Osteoprotegerin-deficient mice develop early onset osteoporosis and arterial calcification
N Bucay, I Sarosi, CR Dunstan, S Morony, J Tarpley, C Capparelli, ...
Genes & development 12 (9), 1260-1268, 1998
Tumor necrosis factor receptor family member RANK mediates osteoclast differentiation and activation induced by osteoprotegerin ligand
H Hsu, DL Lacey, CR Dunstan, I Solovyev, A Colombero, E Timms, ...
Proceedings of the National Academy of Sciences 96 (7), 3540-3545, 1999
Increased bone formation in osteocalcin-deficient mice
P Ducy, C Desbois, B Boyce, G Pinero, B Story, C Dunstan, E Smith, ...
Nature 382 (6590), 448-452, 1996
The roles of osteoprotegerin and osteoprotegerin ligand in the paracrine regulation of bone resorption
LC Hofbauer, S Khosla, CR Dunstan, DL Lacey, WJ Boyle, BL Riggs
Journal of Bone and Mineral Research 15 (1), 2-12, 2000
TRAF6 deficiency results in osteopetrosis and defective interleukin-1, CD40, and LPS signaling
MA Lomaga, WC Yeh, I Sarosi, GS Duncan, C Furlonger, A Ho, S Morony, ...
Genes & development 13 (8), 1015-1024, 1999
RANK is the intrinsic hematopoietic cell surface receptor that controls osteoclastogenesis and regulation of bone mass and calcium metabolism
J Li, I Sarosi, XQ Yan, S Morony, C Capparelli, HL Tan, S McCabe, ...
Proceedings of the national academy of sciences 97 (4), 1566-1571, 2000
Stimulation of osteoprotegerin ligand and inhibition of osteoprotegerin production by glucocorticoids in human osteoblastic lineage cells: potential paracrine mechanisms of …
LC Hofbauer, F Gori, BL Riggs, DL Lacey, CR Dunstan, TC Spelsberg, ...
Endocrinology 140 (10), 4382-4389, 1999
The ligand for osteoprotegerin (OPGL) directly activates mature osteoclasts
TL Burgess, Y Qian, S Kaufman, BD Ring, G Van, C Capparelli, M Kelley, ...
The Journal of cell biology 145 (3), 527-538, 1999
Estrogen stimulates gene expression and protein production of osteoprotegerin in human osteoblastic cells
LC Hofbauer, S Khosla, CR Dunstan, DL Lacey, TC Spelsberg, BL Riggs
Endocrinology 140 (9), 4367-4370, 1999
A single‐dose placebo‐controlled study of AMG 162, a fully human monoclonal antibody to RANKL, in postmenopausal women
PJ Bekker, DL Holloway, AS Rasmussen, R Murphy, SW Martin, PT Leese, ...
Journal of Bone and Mineral Research 19 (7), 1059-1066, 2004
Interleukin-1β and tumor necrosis factor-α, but not interleukin-6, stimulate osteoprotegerin ligand gene expression in human osteoblastic cells
LC Hofbauer, DL Lacey, CR Dunstan, TC Spelsberg, BL Riggs, S Khosla
Bone 25 (3), 255-259, 1999
Osteoprotegerin reverses osteoporosis by inhibiting endosteal osteoclasts and prevents vascular calcification by blocking a process resembling osteoclastogenesis
H Min, S Morony, I Sarosi, CR Dunstan, C Capparelli, S Scully, G Van, ...
The Journal of experimental medicine 192 (4), 463-474, 2000
The effect of a single dose of osteoprotegerin in postmenopausal women
PJ Bekker, D Holloway, A Nakanishi, M Arrighi, PT Leese, CR Dunstan
Journal of Bone and Mineral Research 16 (2), 348-360, 2001
Calcification in atherosclerosis: bone biology and chronic inflammation at the arterial crossroads
TM Doherty, K Asotra, LA Fitzpatrick, JH Qiao, DJ Wilkin, RC Detrano, ...
Proceedings of the National Academy of Sciences 100 (20), 11201-11206, 2003
A phase I study of AMGN‐0007, a recombinant osteoprotegerin construct, in patients with multiple myeloma or breast carcinoma related bone metastases
JJ Body, P Greipp, RE Coleman, T Facon, F Geurs, JP Fermand, ...
Cancer: Interdisciplinary International Journal of the American Cancer …, 2003
Osteoprotegerin inhibits the development of osteolytic bone disease in multiple myeloma
PI Croucher, CM Shipman, J Lippitt, M Perry, K Asosingh, A Hijzen, ...
Blood, The Journal of the American Society of Hematology 98 (13), 3534-3540, 2001
Osteoprotegerin production by human osteoblast lineage cells is stimulated by vitamin D, bone morphogenetic protein-2, and cytokines
LC Hofbauer, CR Dunstan, TC Spelsberg, BL Riggs, S Khosla
Biochemical and biophysical research communications 250 (3), 776-781, 1998
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