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Lucas Farnung
Lucas Farnung
Assistant Professor of Cell Biology, Harvard Medical School
Bestätigte E-Mail-Adresse bei hms.harvard.edu - Startseite
Titel
Zitiert von
Zitiert von
Jahr
Structure of replicating SARS-CoV-2 polymerase
HS Hillen, G Kokic, L Farnung, C Dienemann, D Tegunov, P Cramer
Nature 584 (7819), 154-156, 2020
7532020
Mechanism of SARS-CoV-2 polymerase stalling by remdesivir
G Kokic, HS Hillen, D Tegunov, C Dienemann, F Seitz, J Schmitzova, ...
Nature communications 12 (1), 1-7, 2021
5292021
Structure of activated transcription complex Pol II–DSIF–PAF–SPT6
SM Vos, L Farnung, M Boehning, C Wigge, A Linden, H Urlaub, P Cramer
Nature 560 (7720), 607-612, 2018
3582018
Structure of paused transcription complex Pol II–DSIF–NELF
SM Vos, L Farnung, H Urlaub, P Cramer
Nature 560 (7720), 601-606, 2018
3222018
The interaction landscape between transcription factors and the nucleosome
F Zhu, L Farnung, E Kaasinen, B Sahu, Y Yin, B Wei, SO Dodonova, ...
Nature 562 (7725), 76-81, 2018
2982018
Nucleosome–Chd1 structure and implications for chromatin remodelling
L Farnung, SM Vos, C Wigge, P Cramer
Nature 550 (7677), 539-542, 2017
2262017
The structure and substrate specificity of human Cdk12/Cyclin K
CA Bösken, L Farnung, C Hintermair, M Merzel Schachter, ...
Nature communications 5 (1), 3505, 2014
1872014
Structure of complete Pol II–DSIF–PAF–SPT6 transcription complex reveals RTF1 allosteric activation
SM Vos, L Farnung, A Linden, H Urlaub, P Cramer
Nature Structural & Molecular Biology 27 (7), 668-677, 2020
1122020
Structure of transcribing RNA polymerase II-nucleosome complex
L Farnung, SM Vos, P Cramer
Nature communications 9 (1), 5432, 2018
982018
Structural basis of nucleosome transcription mediated by Chd1 and FACT
L Farnung, M Ochmann, M Engeholm, P Cramer
Nature Structural & Molecular Biology 28 (4), 382-387, 2021
862021
Nucleosome-CHD4 chromatin remodeller structure maps human disease mutations
L Farnung, M Ochmann, P Cramer
eLife 9, e56178, 2020
64*2020
Structure of H3K36-methylated nucleosome–PWWP complex reveals multivalent cross-gyre binding
H Wang, L Farnung, C Dienemann, P Cramer
Nature structural & molecular biology 27 (1), 8-13, 2020
642020
Two distinct mechanisms of RNA polymerase II elongation stimulation in vivo
K Žumer, KC Maier, L Farnung, MG Jaeger, P Rus, G Winter, P Cramer
Molecular Cell 81 (15), 3096-3109. e8, 2021
612021
Structural basis of nucleosome retention during transcription elongation
M Filipovski, JHM Soffers, SM Vos, L Farnung
Science 376 (6599), 1313-1316, 2022
472022
Ruler elements in chromatin remodelers set nucleosome array spacing and phasing
E Oberbeckmann, V Niebauer, S Watanabe, L Farnung, M Moldt, ...
Nature Communications 12 (1), 3232, 2021
472021
Cryo-EM structure of a mammalian RNA polymerase II elongation complex inhibited by α-amanitin
X Liu, L Farnung, C Wigge, P Cramer
Journal of Biological Chemistry 293 (19), 7189-7194, 2018
402018
Structure of a backtracked hexasomal intermediate of nucleosome transcription
L Farnung, M Ochmann, G Garg, SM Vos, P Cramer
Molecular Cell 82 (17), 3126-3134. e7, 2022
362022
Assembly of RNA polymerase II transcription initiation complexes
L Farnung, SM Vos
Current opinion in structural biology 73, 102335, 2022
212022
Nucleosomal arrangement affects single-molecule transcription dynamics
V Fitz, J Shin, C Ehrlich, L Farnung, P Cramer, V Zaburdaev, SW Grill
Proceedings of the National Academy of Sciences 113 (45), 12733-12738, 2016
212016
Mechanism of RNA polymerase II stalling by DNA alkylation
S Malvezzi, L Farnung, CMN Aloisi, T Angelov, P Cramer, SJ Sturla
Proceedings of the National Academy of Sciences 114 (46), 12172-12177, 2017
152017
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