Wolfgang  Sippl
Wolfgang Sippl
Professor of Medicinal Chemistry
Bestätigte E-Mail-Adresse bei - Startseite
Zitiert von
Zitiert von
Molecular modeling
HD Holtje, W Sippl, D Rognan, G Folkers
Wiley-VCH, 2003
Masitinib (AB1010), a potent and selective tyrosine kinase inhibitor targeting KIT
P Dubreuil, S Letard, M Ciufolini, L Gros, M Humbert, N Castéran, L Borge, ...
PloS one 4 (9), e7258, 2009
Small-molecule inhibitor of USP7/HAUSP ubiquitin protease stabilizes and activates p53 in cells
F Colland, E Formstecher, X Jacq, C Reverdy, C Planquette, S Conrath, ...
Molecular cancer therapeutics 8 (8), 2286-2295, 2009
Discovery of specific inhibitors of human USP7/HAUSP deubiquitinating enzyme
C Reverdy, S Conrath, R Lopez, C Planquette, C Atmanene, V Collura, ...
Chemistry & biology 19 (4), 467-477, 2012
Chemically induced degradation of sirtuin 2 (Sirt2) by a proteolysis targeting chimera (PROTAC) based on sirtuin rearranging ligands (SirReals)
M Schiedel, D Herp, S Hammelmann, S Swyter, A Lehotzky, D Robaa, ...
Journal of medicinal chemistry 61 (2), 482-491, 2018
HDAC8: a multifaceted target for therapeutic interventions
A Chakrabarti, I Oehme, O Witt, G Oliveira, W Sippl, C Romier, RJ Pierce, ...
Trends in pharmacological sciences 36 (7), 481-492, 2015
Selective Sirt2 inhibition by ligand-induced rearrangement of the active site
T Rumpf, M Schiedel, B Karaman, C Roessler, BJ North, A Lehotzky, ...
Nature communications 6 (1), 6263, 2015
Activation, regulation, and inhibition of DYRK1A
W Becker, W Sippl
The FEBS journal 278 (2), 246-256, 2011
Structure–Activity Studies on Suramin Analogues as Inhibitors of NAD+‐Dependent Histone Deacetylases (Sirtuins)
J Trapp, R Meier, D Hongwiset, MU Kassack, W Sippl, M Jung
ChemMedChem: Chemistry Enabling Drug Discovery 2 (10), 1419-1431, 2007
The potential of anti-malarial compounds derived from African medicinal plants. Part I: A pharmacological evaluation of alkaloids and terpenoids
P Amoa Onguéné, F Ntie-Kang, LL Lifongo, JC Ndom, W Sippl, LM Mbaze
Malaria journal 12, 1-26, 2013
AfroDb: a select highly potent and diverse natural product library from African medicinal plants
F Ntie-Kang, D Zofou, SB Babiaka, R Meudom, M Scharfe, LL Lifongo, ...
PloS one 8 (10), e78085, 2013
Structure–activity studies on splitomicin derivatives as sirtuin inhibitors and computational prediction of binding mode
RC Neugebauer, U Uchiechowska, R Meier, H Hruby, V Valkov, E Verdin, ...
Journal of medicinal chemistry 51 (5), 1203-1213, 2008
The emerging therapeutic potential of histone methyltransferase and demethylase inhibitors
A Spannhoff, AT Hauser, R Heinke, W Sippl, M Jung
ChemMedChem: Chemistry Enabling Drug Discovery 4 (10), 1568-1582, 2009
Adenosine Mimetics as Inhibitors of NAD+-Dependent Histone Deacetylases, from Kinase to Sirtuin Inhibition
J Trapp, A Jochum, R Meier, L Saunders, B Marshall, C Kunick, E Verdin, ...
Journal of medicinal chemistry 49 (25), 7307-7316, 2006
The potential of anti-malarial compounds derived from African medicinal plants, part II: a pharmacological evaluation of non-alkaloids and non-terpenoids
F Ntie-Kang, PA Onguéné, LL Lifongo, JC Ndom, W Sippl, LM Mbaze
Malaria journal 13, 1-20, 2014
Structural Basis for the Inhibition of Histone Deacetylase 8 (HDAC8), a Key Epigenetic Player in the Blood Fluke Schistosoma mansoni
M Marek, S Kannan, AT Hauser, M Moraes Mourão, S Caby, V Cura, ...
PLoS pathogens 9 (9), e1003645, 2013
Target-based approach to inhibitors of histone arginine methyltransferases
A Spannhoff, R Heinke, I Bauer, P Trojer, E Metzger, R Gust, R Schüle, ...
Journal of medicinal chemistry 50 (10), 2319-2325, 2007
Regulation of G2/M transition by inhibition of WEE1 and PKMYT1 kinases
M Schmidt, A Rohe, C Platzer, A Najjar, F Erdmann, W Sippl
Molecules 22 (12), 2045, 2017
Receptor-based 3D QSAR analysis of estrogen receptor ligands–merging the accuracy of receptor-based alignments with the computational efficiency of ligand-based methods
W Sippl
Journal of computer-aided molecular design 14, 559-572, 2000
Design, synthesis, and structure− activity relationships of a series of 3-[2-(1-benzylpiperidin-4-yl) ethylamino] pyridazine derivatives as acetylcholinesterase inhibitors
JM Contreras, I Parrot, W Sippl, YM Rival, CG Wermuth
Journal of medicinal chemistry 44 (17), 2707-2718, 2001
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