| Molecular modeling HD Holtje, W Sippl, D Rognan, G Folkers Wiley-VCH, 2003 | 531 | 2003 |
| Masitinib (AB1010), a potent and selective tyrosine kinase inhibitor targeting KIT P Dubreuil, S Letard, M Ciufolini, L Gros, M Humbert, N Castéran, L Borge, ... PloS one 4 (9), e7258, 2009 | 444 | 2009 |
| Small-molecule inhibitor of USP7/HAUSP ubiquitin protease stabilizes and activates p53 in cells F Colland, E Formstecher, X Jacq, C Reverdy, C Planquette, S Conrath, ... Molecular cancer therapeutics 8 (8), 2286-2295, 2009 | 358 | 2009 |
| Discovery of specific inhibitors of human USP7/HAUSP deubiquitinating enzyme C Reverdy, S Conrath, R Lopez, C Planquette, C Atmanene, V Collura, ... Chemistry & biology 19 (4), 467-477, 2012 | 282 | 2012 |
| Chemically induced degradation of sirtuin 2 (Sirt2) by a proteolysis targeting chimera (PROTAC) based on sirtuin rearranging ligands (SirReals) M Schiedel, D Herp, S Hammelmann, S Swyter, A Lehotzky, D Robaa, ... Journal of medicinal chemistry 61 (2), 482-491, 2018 | 270 | 2018 |
| HDAC8: a multifaceted target for therapeutic interventions A Chakrabarti, I Oehme, O Witt, G Oliveira, W Sippl, C Romier, RJ Pierce, ... Trends in pharmacological sciences 36 (7), 481-492, 2015 | 262 | 2015 |
| Selective Sirt2 inhibition by ligand-induced rearrangement of the active site T Rumpf, M Schiedel, B Karaman, C Roessler, BJ North, A Lehotzky, ... Nature communications 6 (1), 6263, 2015 | 262 | 2015 |
| Activation, regulation, and inhibition of DYRK1A W Becker, W Sippl The FEBS journal 278 (2), 246-256, 2011 | 241 | 2011 |
| Structure–Activity Studies on Suramin Analogues as Inhibitors of NAD+‐Dependent Histone Deacetylases (Sirtuins) J Trapp, R Meier, D Hongwiset, MU Kassack, W Sippl, M Jung ChemMedChem: Chemistry Enabling Drug Discovery 2 (10), 1419-1431, 2007 | 236 | 2007 |
| The potential of anti-malarial compounds derived from African medicinal plants. Part I: A pharmacological evaluation of alkaloids and terpenoids P Amoa Onguéné, F Ntie-Kang, LL Lifongo, JC Ndom, W Sippl, LM Mbaze Malaria journal 12, 1-26, 2013 | 235 | 2013 |
| AfroDb: a select highly potent and diverse natural product library from African medicinal plants F Ntie-Kang, D Zofou, SB Babiaka, R Meudom, M Scharfe, LL Lifongo, ... PloS one 8 (10), e78085, 2013 | 224 | 2013 |
| Structure–activity studies on splitomicin derivatives as sirtuin inhibitors and computational prediction of binding mode RC Neugebauer, U Uchiechowska, R Meier, H Hruby, V Valkov, E Verdin, ... Journal of medicinal chemistry 51 (5), 1203-1213, 2008 | 200 | 2008 |
| The emerging therapeutic potential of histone methyltransferase and demethylase inhibitors A Spannhoff, AT Hauser, R Heinke, W Sippl, M Jung ChemMedChem: Chemistry Enabling Drug Discovery 4 (10), 1568-1582, 2009 | 199 | 2009 |
| Adenosine Mimetics as Inhibitors of NAD+-Dependent Histone Deacetylases, from Kinase to Sirtuin Inhibition J Trapp, A Jochum, R Meier, L Saunders, B Marshall, C Kunick, E Verdin, ... Journal of medicinal chemistry 49 (25), 7307-7316, 2006 | 199 | 2006 |
| The potential of anti-malarial compounds derived from African medicinal plants, part II: a pharmacological evaluation of non-alkaloids and non-terpenoids F Ntie-Kang, PA Onguéné, LL Lifongo, JC Ndom, W Sippl, LM Mbaze Malaria journal 13, 1-20, 2014 | 196 | 2014 |
| Structural Basis for the Inhibition of Histone Deacetylase 8 (HDAC8), a Key Epigenetic Player in the Blood Fluke Schistosoma mansoni M Marek, S Kannan, AT Hauser, M Moraes Mourão, S Caby, V Cura, ... PLoS pathogens 9 (9), e1003645, 2013 | 194 | 2013 |
| Target-based approach to inhibitors of histone arginine methyltransferases A Spannhoff, R Heinke, I Bauer, P Trojer, E Metzger, R Gust, R Schüle, ... Journal of medicinal chemistry 50 (10), 2319-2325, 2007 | 168 | 2007 |
| Regulation of G2/M transition by inhibition of WEE1 and PKMYT1 kinases M Schmidt, A Rohe, C Platzer, A Najjar, F Erdmann, W Sippl Molecules 22 (12), 2045, 2017 | 165 | 2017 |
| Receptor-based 3D QSAR analysis of estrogen receptor ligands–merging the accuracy of receptor-based alignments with the computational efficiency of ligand-based methods W Sippl Journal of computer-aided molecular design 14, 559-572, 2000 | 155 | 2000 |
| Design, synthesis, and structure− activity relationships of a series of 3-[2-(1-benzylpiperidin-4-yl) ethylamino] pyridazine derivatives as acetylcholinesterase inhibitors JM Contreras, I Parrot, W Sippl, YM Rival, CG Wermuth Journal of medicinal chemistry 44 (17), 2707-2718, 2001 | 142 | 2001 |
