Bruce M. Spiegelman
Bruce M. Spiegelman
Stanley J. Korsmeyer Professor, Harvard Medical School and Dana-Farber Cancer Institute
Verified email at
Cited by
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Adipose expression of tumor necrosis factor-alpha: direct role in obesity-linked insulin resistance
GS Hotamisligil, NS Shargill, BM Spiegelman
Science 259 (5091), 87-91, 1993
PGC-1α-responsive genes involved in oxidative phosphorylation are coordinately downregulated in human diabetes
VK Mootha, CM Lindgren, KF Eriksson, A Subramanian, S Sihag, J Lehar, ...
Nature genetics 34 (3), 267-273, 2003
Increased adipose tissue expression of tumor necrosis factor-alpha in human obesity and insulin resistance.
GS Hotamisligil, P Arner, JF Caro, RL Atkinson, BM Spiegelman
The Journal of clinical investigation 95 (5), 2409-2415, 1995
Stimulation of adipogenesis in fibroblasts by PPARγ2, a lipid-activated transcription factor
P Tontonoz, E Hu, BM Spiegelman
Cell 79 (7), 1147-1156, 1994
A cold-inducible coactivator of nuclear receptors linked to adaptive thermogenesis
P Puigserver, Z Wu, CW Park, R Graves, M Wright, BM Spiegelman
Cell 92 (6), 829-839, 1998
Mechanisms controlling mitochondrial biogenesis and respiration through the thermogenic coactivator PGC-1
Z Wu, P Puigserver, U Andersson, C Zhang, G Adelmant, V Mootha, ...
Cell 98 (1), 115-124, 1999
15-deoxy-Δ12, 14-prostaglandin J2 is a ligand for the adipocyte determination factor PPARγ
BM Forman, P Tontonoz, J Chen, RP Brun, BM Spiegelman, RM Evans
Cell 83 (5), 803-812, 1995
A PGC1-α-dependent myokine that drives brown-fat-like development of white fat and thermogenesis
P Boström, J Wu, MP Jedrychowski, A Korde, L Ye, JC Lo, KA Rasbach, ...
Nature 481 (7382), 463-468, 2012
IRS-1-mediated inhibition of insulin receptor tyrosine kinase activity in TNF-α-and obesity-induced insulin resistance
GS Hotamisligil, P Peraldi, A Budavari, R Ellis, MF White, BM Spiegelman
Science 271 (5249), 665-670, 1996
Nutrient control of glucose homeostasis through a complex of PGC-1α and SIRT1
JT Rodgers, C Lerin, W Haas, SP Gygi, BM Spiegelman, P Puigserver
Nature 434 (7029), 113-118, 2005
AdipoQ is a novel adipose-specific gene dysregulated in obesity
E Hu, P Liang, BM Spiegelman
Journal of biological chemistry 271 (18), 10697-10703, 1996
Obesity and the regulation of energy balance
BM Spiegelman, JS Flier
cell 104 (4), 531-543, 2001
mPPAR gamma 2: tissue-specific regulator of an adipocyte enhancer.
P Tontonoz, E Hu, RA Graves, AI Budavari, BM Spiegelman
Genes & development 8 (10), 1224-1234, 1994
Beige adipocytes are a distinct type of thermogenic fat cell in mouse and human
J Wu, P Boström, LM Sparks, L Ye, JH Choi, AH Giang, M Khandekar, ...
Cell 150 (2), 366-376, 2012
Transcriptional co-activator PGC-1α drives the formation of slow-twitch muscle fibres
J Lin, H Wu, PT Tarr, CY Zhang, Z Wu, O Boss, LF Michael, P Puigserver, ...
Nature 418 (6899), 797-801, 2002
PPAR-gamma: adipogenic regulator and thiazolidinedione receptor.
BM Spiegelman
Diabetes 47 (4), 507-514, 1998
PPARγ is required for the differentiation of adipose tissue in vivo and in vitro
ED Rosen, P Sarraf, AE Troy, G Bradwin, K Moore, DS Milstone, ...
Molecular cell 4 (4), 611-617, 1999
Transcriptional regulation of adipogenesis
ED Rosen, CJ Walkey, P Puigserver, BM Spiegelman
Genes & development 14 (11), 1293-1307, 2000
AMP-activated protein kinase (AMPK) action in skeletal muscle via direct phosphorylation of PGC-1α
S Jäger, C Handschin, JS Pierre, BM Spiegelman
Proceedings of the National Academy of Sciences 104 (29), 12017-12022, 2007
Adipocytes as regulators of energy balance and glucose homeostasis
ED Rosen, BM Spiegelman
Nature 444 (7121), 847-853, 2006
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