| Structures of closed and open conformations of dimeric human ATM D Baretić, HK Pollard, DI Fisher, CM Johnson, B Santhanam, CM Truman, ... Science advances 3 (5), e1700933, 2017 | 109 | 2017 |
| Discovery of AZD9833, a potent and orally bioavailable selective estrogen receptor degrader and antagonist JS Scott, TA Moss, A Balazs, B Barlaam, J Breed, RJ Carbajo, ... Journal of Medicinal Chemistry 63 (23), 14530-14559, 2020 | 66 | 2020 |
| Nudix hydrolases that degrade dinucleoside and diphosphoinositol polyphosphates also have 5-phosphoribosyl 1-pyrophosphate (PRPP) pyrophosphatase activity that generates the … DI Fisher, ST Safrany, P Strike, AG McLennan, JL Cartwright Journal of Biological Chemistry 277 (49), 47313-47317, 2002 | 66 | 2002 |
| Systematic evaluation of CRISPRa and CRISPRi modalities enables development of a multiplexed, orthogonal gene activation and repression system A Martella, M Firth, BJM Taylor, A Göppert, EM Cuomo, RG Roth, ... ACS Synthetic Biology 8 (9), 1998-2006, 2019 | 42 | 2019 |
| Characterization of a Nudix hydrolase from Deinococcus radiodurans with a marked specificity for (deoxy)ribonucleoside 5'-diphosphates DI Fisher, JL Cartwright, H Harashima, H Kamiya, AG McLennan BMC biochemistry 5, 1-8, 2004 | 31 | 2004 |
| Correlation of intracellular diadenosine triphosphate (Ap3A) with apoptosis in Fhit-positive HEK293 cells DI Fisher, AG McLennan Cancer letters 259 (2), 186-191, 2008 | 30 | 2008 |
| Optimisation of a simple method to transiently transfect a CHO cell line in high-throughput and at large scale WM Abbott, B Middleton, F Kartberg, J Claesson, R Roth, D Fisher Protein Expression and Purification 116, 113-119, 2015 | 28 | 2015 |
| Structural insights into the critical DNA damage sensors DNA-PKcs, ATM and ATR D Baretic, TM de Oliveira, M Niess, P Wan, H Pollard, CM Johnson, ... Progress in biophysics and molecular biology 147, 4-16, 2019 | 26 | 2019 |
| Use of a protein engineering strategy to overcome limitations in the production of “Difficult to Express” recombinant proteins H Hussain, DI Fisher, WM Abbott, RG Roth, AJ Dickson Biotechnology and bioengineering 114 (10), 2348-2359, 2017 | 21 | 2017 |
| Characterization of the Mn2+-stimulated (di)adenosine polyphosphate hydrolase encoded by the Deinococcus radiodurans DR2356 nudix gene DI Fisher, JL Cartwright, AG McLennan Archives of microbiology 186, 415-424, 2006 | 12 | 2006 |
| Discovery of AZD9833, an oral small molecule selective degrader of the estrogen receptor (SERD) JS Scott, T Moss, S Stokes, WM Nissink, CJ Morrow, M Lawson, ... Cancer Research 80 (16_Supplement), 5674-5674, 2020 | 11 | 2020 |
| Phosphorylation of the multifunctional signal transducer B-cell adaptor protein (BCAP) promotes recruitment of multiple SH2/SH3 proteins including GRB2 JU Lauenstein, A Udgata, A Bartram, D De Sutter, DI Fisher, S Halabi, ... Journal of Biological Chemistry 294 (52), 19852-19861, 2019 | 11 | 2019 |
| A protein chimera strategy supports production of a model “difficult‐to‐express” recombinant target H Hussain, DI Fisher, RG Roth, W Mark Abbott, MA Carballo‐Amador, ... FEBS letters 592 (14), 2499-2511, 2018 | 11 | 2018 |
| Chromosome-level genome assembly and population genomic resource to accelerate orphan crop lablab breeding I Njaci, B Waweru, N Kamal, MS Muktar, D Fisher, H Gundlach, C Muli, ... Nature Communications 14 (1), 1915, 2023 | 10 | 2023 |
| Antibody fragments structurally enable a drug-discovery campaign on the cancer target Mcl-1 J Luptak, M Bista, D Fisher, L Flavell, N Gao, K Wickson, SL Kazmirski, ... Acta Crystallographica Section D: Structural Biology 75 (11), 1003-1014, 2019 | 10 | 2019 |
| Regulation of gene expression and the elucidative role of CRISPR-based epigenetic modifiers and CRISPR-induced chromosome conformational changes A Martella, DI Fisher The CRISPR Journal 4 (1), 43-57, 2021 | 9 | 2021 |
| Discovery of a Potent and Orally Bioavailable Zwitterionic Series of Selective Estrogen Receptor Degrader-Antagonists JS Scott, D Stead, B Barlaam, J Breed, RJ Carbajo, E Chiarparin, ... Journal of Medicinal Chemistry 66 (4), 2918-2945, 2023 | 7 | 2023 |
| Development of a medium-throughput targeted LCMS assay to detect endogenous cellular levels of malonyl-CoA to screen fatty acid synthase inhibitors PJ Hopcroft, DI Fisher Journal of Biomolecular Screening 21 (2), 111-116, 2016 | 7 | 2016 |
| Negative regulation of TLR signaling by BCAP requires dimerization of Its DBB domain JU Lauenstein, MJ Scherm, A Udgata, MC Moncrieffe, DI Fisher, NJ Gay The Journal of Immunology 204 (8), 2269-2276, 2020 | 6 | 2020 |
| The Next-Generation Oral Selective Estrogen Receptor Degrader Camizestrant (AZD9833) Suppresses ER+ Breast Cancer Growth and Overcomes Endocrine and … M Lawson, N Cureton, S Ros, A Cheraghchi-Bashi, J Urosevic, S D'Arcy, ... Cancer Research 83 (23), 3989-4004, 2023 | 5 | 2023 |
