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Youngdon Kwak
Youngdon Kwak
Principal Scientist ll, Novartis institutes for Biomedical Research (NIBR)
Bestätigte E-Mail-Adresse bei novartis.com
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Antidiabetic drug metformin (GlucophageR) increases biogenesis of Alzheimer's amyloid peptides via up-regulating BACE1 transcription
Y Chen, K Zhou, R Wang, Y Liu, YD Kwak, T Ma, RC Thompson, Y Zhao, ...
Proceedings of the National Academy of Sciences 106 (10), 3907-3912, 2009
4682009
Metabolic stress modulates Alzheimer’s β-secretase gene transcription via SIRT1-PPARγ-PGC-1 in neurons
R Wang, JJ Li, S Diao, YD Kwak, L Liu, L Zhi, H Büeler, NR Bhat, ...
Cell metabolism 17 (5), 685-694, 2013
2152013
NO signaling and S-nitrosylation regulate PTEN inhibition in neurodegeneration
YD Kwak, T Ma, S Diao, X Zhang, Y Chen, J Hsu, SA Lipton, E Masliah, ...
Molecular neurodegeneration 5, 1-12, 2010
1642010
Amyloid precursor protein regulates differentiation of human neural stem cells
YD Kwak, CL Brannen, T Qu, HM Kim, X Dong, P Soba, A Majumdar, ...
Stem cells and development 15 (3), 381-389, 2006
1472006
Differential regulation of BACE1 expression by oxidative and nitrosative signals
YD Kwak, R Wang, JJ Li, YW Zhang, H Xu, FF Liao
Molecular neurodegeneration 6, 1-10, 2011
1052011
Upregulation of the E3 ligase NEDD4-1 by oxidative stress degrades IGF-1 receptor protein in neurodegeneration
YD Kwak, B Wang, JJ Li, R Wang, Q Deng, S Diao, Y Chen, R Xu, ...
Journal of Neuroscience 32 (32), 10971-10981, 2012
912012
The Hippo pathway prevents YAP/TAZ-driven hypertranscription and controls neural progenitor number
A Lavado, JY Park, J Pare, D Finkelstein, H Pan, B Xu, Y Fan, RP Kumar, ...
Developmental cell 47 (5), 576-591. e8, 2018
882018
Stem cell strategies for Alzheimer's disease therapy.
K Sugaya, A Alvarez, A Marutle, YD Kwak, E Choumkina
Panminerva medica 48 (2), 87-96, 2006
792006
Cell Surface Display of Human Immunodeficiency Virus Type 1 gp120 on Escherichia coli by Using Ice Nucleation Protein
YD Kwak, SK Yoo, EJ Kim
Clinical Diagnostic Laboratory Immunology 6 (4), 499-503, 1999
741999
Statin's excitoprotection is mediated by sAPP and the subsequent attenuation of calpain-induced truncation events, likely via rho-ROCK signaling
T Ma, YB Zhao, YD Kwak, Z Yang, R Thompson, Z Luo, H Xu, FF Liao
Journal of Neuroscience 29 (36), 11226-11236, 2009
672009
Practical issues in stem cell therapy for Alzheimer's disease
K Sugaya, YD Kwak, O Ohmitsu, A Marutle, NH Greig, E Choumrina
Current Alzheimer Research 4 (4), 370-377, 2007
622007
Functional interaction of phosphatase and tensin homologue (PTEN) with the E3 ligase NEDD4-1 during neuronal response to zinc
YD Kwak, B Wang, W Pan, H Xu, X Jiang, FF Liao
Journal of biological chemistry 285 (13), 9847-9857, 2010
602010
RNA interference with small hairpin RNAs transcribed from a human U6 promoter-driven DNA vector
YD Kwak, H Koike, K Sugaya
Journal of pharmacological sciences 93 (2), 214-217, 2003
412003
Secreted type of amyloid precursor protein induces glial differentiation by stimulating the BMP/Smad signaling pathway
YD Kwak, BJ Hendrix, K Sugaya
Biochemical and Biophysical Research Communications 447 (3), 394-399, 2014
352014
Amyloid-β precursor protein induces glial differentiation of neural progenitor cells by activation of the IL-6/gp130 signaling pathway
YD Kwak, E Dantuma, S Merchant, S Bushnev, K Sugaya
Neurotoxicity research 18, 328-338, 2010
332010
Human zinc finger protein 161, a novel transcriptional activator of the dopamine transporter
KH Lee, YD Kwak, DH Kim, MY Chang, YS Lee, YS Lee
Biochemical and biophysical research communications 313 (4), 969-976, 2004
302004
Involvement of notch signaling pathway in amyloid precursor protein induced glial differentiation
YD Kwak, A Marutle, E Dantuma, S Merchant, S Bushnev, K Sugaya
European journal of pharmacology 650 (1), 18-27, 2011
292011
Amyloid precursor protein is involved in staurosporine induced glial differentiation of neural progenitor cells
YD Kwak, E Choumkina, K Sugaya
Biochemical and biophysical research communications 344 (1), 431-437, 2006
272006
Apurinic endonuclease-1 preserves neural genome integrity to maintain homeostasis and thermoregulation and prevent brain tumors
LC Dumitrache, M Shimada, SM Downing, YD Kwak, Y Li, JL Illuzzi, ...
Proceedings of the National Academy of Sciences 115 (52), E12285-E12294, 2018
262018
Genome instability independent of type I interferon signaling drives neuropathology caused by impaired ribonucleotide excision repair
SM Downing, PA Schreiner, YD Kwak, Y Li, TI Shaw, HR Russell, ...
Neuron 109 (24), 3962-3979. e6, 2021
252021
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