J. Nicholas (Nick) Cochran, Ph.D.
J. Nicholas (Nick) Cochran, Ph.D.
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Amyloid-β signals through tau to drive ectopic neuronal cell cycle re-entry in Alzheimer's disease
ME Seward, E Swanson, A Norambuena, A Reimann, JN Cochran, R Li, ...
Journal of cell science 126 (5), 1278-1286, 2013
Genomic diagnosis for children with intellectual disability and/or developmental delay
KM Bowling, ML Thompson, MD Amaral, CR Finnila, SM Hiatt, KL Engel, ...
Genome medicine 9 (1), 1-11, 2017
The dendritic hypothesis for Alzheimer's disease pathophysiology
JN Cochran, AM Hall, ED Roberson
Brain research bulletin 103, 18-28, 2014
Therapeutic response in feline sandhoff disease despite immunity to intracranial gene therapy
AM Bradbury, JN Cochran, VJ McCurdy, AK Johnson, BL Brunson, ...
Molecular Therapy 21 (7), 1306-1315, 2013
Aberrant inclusion of a poison exon causes dravet syndrome and related SCN1A-associated genetic epilepsies
GL Carvill, KL Engel, A Ramamurthy, JN Cochran, J Roovers, ...
The American Journal of Human Genetics 103 (6), 1022-1029, 2018
De novo mutations in MED13, a component of the Mediator complex, are associated with a novel neurodevelopmental disorder
L Snijders Blok, SM Hiatt, KM Bowling, JW Prokop, KL Engel, JN Cochran, ...
Human genetics 137 (5), 375-388, 2018
The Alzheimer's disease risk factor CD2AP maintains blood–brain barrier integrity
JN Cochran, T Rush, SC Buckingham, ED Roberson
Human molecular genetics 24 (23), 6667-6674, 2015
Non-coding and loss-of-function coding variants in TET2 are associated with multiple neurodegenerative diseases
JN Cochran, EG Geier, LW Bonham, JS Newberry, MD Amaral, ...
The American Journal of Human Genetics 106 (5), 632-645, 2020
Systematic reanalysis of genomic data improves quality of variant interpretation
SM Hiatt, MD Amaral, KM Bowling, CR Finnila, ML Thompson, DE Gray, ...
Clinical genetics 94 (1), 174-178, 2018
Genetic origin of a large family with a novel PSEN1 mutation (Ile416Thr)
LR Aguilar, J Acosta-Uribe, MM Giraldo, S Moreno, A Baena, D Alzate, ...
Alzheimer's & Dementia 15 (5), 709-719, 2019
Rare variants in the neuronal ceroid lipofuscinosis gene MFSD8 are candidate risk factors for frontotemporal dementia
EG Geier, M Bourdenx, NJ Storm, JN Cochran, DW Sirkis, JH Hwang, ...
Acta neuropathologica 137 (1), 71-88, 2019
Genome sequencing for early-onset or atypical dementia: high diagnostic yield and frequent observation of multiple contributory alleles
JN Cochran, EC McKinley, M Cochran, MD Amaral, BA Moyers, ...
Molecular Case Studies 5 (6), a003491, 2019
The multi-partner consortium to expand dementia research in Latin America (ReDLat): driving multicentric research and implementation science
A Ibanez, JS Yokoyama, KL Possin, D Matallana, F Lopera, R Nitrini, ...
Frontiers in neurology 12, 631722, 2021
AlphaScreen HTS and live-cell bioluminescence resonance energy transfer (BRET) assays for identification of tau–fyn SH3 interaction inhibitors for Alzheimer disease
JN Cochran, PV Diggs, NM Nebane, L Rasmussen, EL White, R Bostwick, ...
Journal of biomolecular screening 19 (10), 1338-1349, 2014
Exome sequencing identifies rare damaging variants in the ATB8B4 and ABCA1 genes as novel risk factors for Alzheimer’s disease
H Holstege, M Hulsman, C Charbonnier, B Grenier‐Boley, O Quenez, ...
Alzheimer's & Dementia 17, e055982, 2021
Alzheimer’s disease risk gene BIN1 induces Tau-dependent network hyperexcitability
Y Voskobiynyk, JR Roth, JN Cochran, T Rush, NVN Carullo, JS Mesina, ...
Elife 9, e57354, 2020
A peptide inhibitor of Tau-SH3 interactions ameliorates amyloid-β toxicity
T Rush, JR Roth, SJ Thompson, AR Aldaher, JN Cochran, ED Roberson
Neurobiology of disease 134, 104668, 2020
Aberrant regulation of a poison exon caused by a non-coding variant in a mouse model of Scn1a-associated epileptic encephalopathy
Y Voskobiynyk, G Battu, SA Felker, JN Cochran, MP Newton, LJ Lambert, ...
PLoS genetics 17 (1), e1009195, 2021
Understanding the present and preparing for the future: Exploring the needs of diagnostic and elective genomic medicine patients
KM East, M Cochran, WV Kelley, V Greve, K Emmerson, G Raines, ...
Journal of Genetic Counseling 28 (2), 438-448, 2019
Clinical, imaging, pathological, and biochemical characterization of a novel presenilin 1 mutation (N135Y) causing Alzheimer's disease
MN Love, DG Clark, JN Cochran, KA Den Beste, DS Geldmacher, ...
Neurobiology of aging 49, 216. e7-216. e13, 2017
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