| Genome-scale CRISPR-Cas9 knockout screening in human cells O Shalem, NE Sanjana, E Hartenian, X Shi, DA Scott, TS Mikkelsen, ... Science 343 (6166), 84-87, 2014 | 5485 | 2014 |
| Lenalidomide causes selective degradation of IKZF1 and IKZF3 in multiple myeloma cells J Krönke, ND Udeshi, A Narla, P Grauman, SN Hurst, M McConkey, ... Science 343 (6168), 301-305, 2014 | 1642 | 2014 |
| Single-cell RNA-seq reveals changes in cell cycle and differentiation programs upon aging of hematopoietic stem cells MS Kowalczyk, I Tirosh, D Heckl, TN Rao, A Dixit, BJ Haas, RK Schneider, ... Genome research 25 (12), 1860-1872, 2015 | 664 | 2015 |
| Generation of mouse models of myeloid malignancy with combinatorial genetic lesions using CRISPR-Cas9 genome editing D Heckl, MS Kowalczyk, D Yudovich, R Belizaire, RV Puram, ... Nature biotechnology 32 (9), 941-946, 2014 | 608 | 2014 |
| Refined sgRNA efficacy prediction improves large-and small-scale CRISPR–Cas9 applications M Labuhn, FF Adams, M Ng, S Knoess, A Schambach, EM Charpentier, ... Nucleic acids research 46 (3), 1375-1385, 2018 | 249 | 2018 |
| Gli1+ mesenchymal stromal cells are a key driver of bone marrow fibrosis and an important cellular therapeutic target RK Schneider, A Mullally, A Dugourd, F Peisker, R Hoogenboezem, ... Cell stem cell 20 (6), 785-800. e8, 2017 | 245 | 2017 |
| Core circadian clock genes regulate leukemia stem cells in AML RV Puram, MS Kowalczyk, CG de Boer, RK Schneider, PG Miller, ... Cell 165 (2), 303-316, 2016 | 229 | 2016 |
| Role of casein kinase 1A1 in the biology and targeted therapy of del (5q) MDS RK Schneider, V Adema, D Heckl, M Järås, M Mallo, AM Lord, LP Chu, ... Cancer cell 26 (4), 509-520, 2014 | 203 | 2014 |
| Depletion of Jak2V617F myeloproliferative neoplasm-propagating stem cells by interferon-α in a murine model of polycythemia vera A Mullally, C Bruedigam, L Poveromo, FH Heidel, A Purdon, T Vu, ... Blood, The Journal of the American Society of Hematology 121 (18), 3692-3702, 2013 | 179 | 2013 |
| Pharmacological GLI2 inhibition prevents myofibroblast cell-cycle progression and reduces kidney fibrosis R Kramann, SV Fleig, RK Schneider, SL Fabian, DP DiRocco, O Maarouf, ... The Journal of clinical investigation 125 (8), 2935-2951, 2015 | 160 | 2015 |
| The non-coding RNA landscape of human hematopoiesis and leukemia A Schwarzer, S Emmrich, F Schmidt, D Beck, M Ng, C Reimer, FF Adams, ... Nature communications 8 (1), 1-17, 2017 | 156 | 2017 |
| Oncogenic models based on delivery and use of the crispr-cas systems, vectors and compositions F Zhang, BL Ebert, D Heckl | 122 | 2016 |
| Mechanisms of progression of myeloid preleukemia to transformed myeloid leukemia in children with Down syndrome M Labuhn, K Perkins, S Matzk, L Varghese, C Garnett, E Papaemmanuil, ... Cancer cell 36 (2), 123-138. e10, 2019 | 120 | 2019 |
| Efficient generation of gene-modified human natural killer cells via alpharetroviral vectors JD Suerth, MA Morgan, S Kloess, D Heckl, C Neudörfl, CS Falk, U Koehl, ... Journal of molecular medicine 94, 83-93, 2016 | 80 | 2016 |
| CRISPR-Cas9-induced t (11; 19)/MLL-ENL translocations initiate leukemia in human hematopoietic progenitor cells in vivo J Reimer, S Knöß, M Labuhn, EM Charpentier, G Göhring, ... Haematologica 102 (9), 1558, 2017 | 79 | 2017 |
| Copy-number and gene dependency analysis reveals partial copy loss of wild-type SF3B1 as a novel cancer vulnerability BR Paolella, WJ Gibson, LM Urbanski, JA Alberta, TI Zack, ... Elife 6, e23268, 2017 | 78 | 2017 |
| LncRNA-SLC16A1-AS1 induces metabolic reprogramming during Bladder Cancer progression as target and co-activator of E2F1 S Logotheti, S Marquardt, SK Gupta, C Richter, BAH Edelhäuser, ... Theranostics 10 (21), 9620, 2020 | 70 | 2020 |
| Lentiviral vector induced insertional haploinsufficiency of Ebf1 causes murine leukemia D Heckl, A Schwarzer, R Haemmerle, D Steinemann, C Rudolph, ... Molecular Therapy 20 (6), 1187-1195, 2012 | 69 | 2012 |
| Endogenous tumor suppressor microRNA-193b: therapeutic and prognostic value in acute myeloid leukemia R Bhayadia, K Krowiorz, N Haetscher, R Jammal, S Emmrich, ... Journal of Clinical Oncology 36 (10), 1007-1016, 2018 | 65 | 2018 |
| Jak2V617F and Dnmt3a loss cooperate to induce myelofibrosis through activated enhancer-driven inflammation S Jacquelin, J Straube, L Cooper, T Vu, A Song, M Bywater, E Baxter, ... Blood, The Journal of the American Society of Hematology 132 (26), 2707-2721, 2018 | 64 | 2018 |
