Will Sheffler
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ROSETTA3: an object-oriented software suite for the simulation and design of macromolecules
A Leaver-Fay, M Tyka, SM Lewis, OF Lange, J Thompson, R Jacak, ...
Methods in enzymology 487, 545-574, 2011
Computational design of self-assembling protein nanomaterials with atomic level accuracy
NP King, W Sheffler, MR Sawaya, BS Vollmar, JP Sumida, I André, ...
Science 336 (6085), 1171-1174, 2012
Accurate design of co-assembling multi-component protein nanomaterials
NP King, JB Bale, W Sheffler, DE McNamara, S Gonen, T Gonen, ...
Nature 510 (7503), 103-108, 2014
Structure prediction for CASP8 with all‐atom refinement using Rosetta
S Raman, R Vernon, J Thompson, M Tyka, R Sadreyev, J Pei, D Kim, ...
Proteins: Structure, Function, and Bioinformatics 77 (S9), 89-99, 2009
Accurate design of megadalton-scale two-component icosahedral protein complexes
JB Bale, S Gonen, Y Liu, W Sheffler, D Ellis, C Thomas, D Cascio, ...
Science 353 (6297), 389-394, 2016
A new generation of crystallographic validation tools for the protein data bank
RJ Read, PD Adams, WB Arendall, AT Brunger, P Emsley, RP Joosten, ...
Structure 19 (10), 1395-1412, 2011
Design of a hyperstable 60-subunit protein icosahedron
Y Hsia, JB Bale, S Gonen, D Shi, W Sheffler, KK Fong, U Nattermann, ...
Nature 535 (7610), 136-139, 2016
Induction of potent neutralizing antibody responses by a designed protein nanoparticle vaccine for respiratory syncytial virus
J Marcandalli, B Fiala, S Ols, M Perotti, W de van der Schueren, J Snijder, ...
Cell 176 (6), 1420-1431. e17, 2019
De novo design of a fluorescence-activating β-barrel
J Dou, AA Vorobieva, W Sheffler, LA Doyle, H Park, MJ Bick, B Mao, ...
Nature 561 (7724), 485-491, 2018
Structure prediction for CASP7 targets using extensive all‐atom refinement with Rosetta@ home
R Das, B Qian, S Raman, R Vernon, J Thompson, P Bradley, S Khare, ...
Proteins: Structure, Function, and Bioinformatics 69 (S8), 118-128, 2007
De novo design of protein structure and function with RFdiffusion
JL Watson, D Juergens, NR Bennett, BL Trippe, J Yim, HE Eisenach, ...
Nature 620 (7976), 1089-1100, 2023
Design of protein-binding proteins from the target structure alone
L Cao, B Coventry, I Goreshnik, B Huang, W Sheffler, JS Park, KM Jude, ...
Nature 605 (7910), 551-560, 2022
Accurate computational design of multipass transmembrane proteins
P Lu, D Min, F DiMaio, KY Wei, MD Vahey, SE Boyken, Z Chen, JA Fallas, ...
Science 359 (6379), 1042-1046, 2018
RosettaHoles: rapid assessment of protein core packing for structure prediction, refinement, design, and validation
W Sheffler, D Baker
Protein Science 18 (1), 229-239, 2009
Computational design of self-assembling cyclic protein homo-oligomers
JA Fallas, G Ueda, W Sheffler, V Nguyen, DE McNamara, B Sankaran, ...
Nature chemistry 9 (4), 353-360, 2017
Enhancing and shaping the immunogenicity of native-like HIV-1 envelope trimers with a two-component protein nanoparticle
PJM Brouwer, A Antanasijevic, Z Berndsen, A Yasmeen, B Fiala, TPL Bijl, ...
Nature Communications 10 (1), 4272, 2019
Broadly applicable and accurate protein design by integrating structure prediction networks and diffusion generative models
JL Watson, D Juergens, NR Bennett, BL Trippe, J Yim, HE Eisenach, ...
BioRxiv, 2022.12. 09.519842, 2022
De novo design of self-assembling helical protein filaments
H Shen, JA Fallas, E Lynch, W Sheffler, B Parry, N Jannetty, J Decarreau, ...
Science 362 (6415), 705-709, 2018
Efficient flexible backbone protein–protein docking for challenging targets
NA Marze, SS Roy Burman, W Sheffler, JJ Gray
Bioinformatics 34 (20), 3461-3469, 2018
Computational design of trimeric influenza-neutralizing proteins targeting the hemagglutinin receptor binding site
EM Strauch, SM Bernard, D La, AJ Bohn, PS Lee, CE Anderson, ...
Nature biotechnology 35 (7), 667-671, 2017
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