High-fidelity CRISPR–Cas9 nucleases with no detectable genome-wide off-target effects BP Kleinstiver, V Pattanayak, MS Prew, SQ Tsai, NT Nguyen, Z Zheng, ... Nature 529 (7587), 490-495, 2016 | 2804 | 2016 |
GUIDE-seq enables genome-wide profiling of off-target cleavage by CRISPR-Cas nucleases SQ Tsai, Z Zheng, NT Nguyen, M Liebers, VV Topkar, V Thapar, ... Nature biotechnology 33 (2), 187-197, 2015 | 2256 | 2015 |
Engineered CRISPR-Cas9 nucleases with altered PAM specificities BP Kleinstiver, MS Prew, SQ Tsai, VV Topkar, NT Nguyen, Z Zheng, ... Nature 523 (7561), 481-485, 2015 | 1863 | 2015 |
CIRCLE-seq: a highly sensitive in vitro screen for genome-wide CRISPR–Cas9 nuclease off-targets SQ Tsai, NT Nguyen, J Malagon-Lopez, VV Topkar, MJ Aryee, JK Joung Nature methods 14 (6), 607-614, 2017 | 713 | 2017 |
Broadening the targeting range of Staphylococcus aureus CRISPR-Cas9 by modifying PAM recognition BP Kleinstiver, MS Prew, SQ Tsai, NT Nguyen, VV Topkar, Z Zheng, ... Nature biotechnology 33 (12), 1293-1298, 2015 | 704 | 2015 |
Genome-wide specificities of CRISPR-Cas Cpf1 nucleases in human cells BP Kleinstiver, SQ Tsai, MS Prew, NT Nguyen, MM Welch, JM Lopez, ... Nature biotechnology 34 (8), 869-874, 2016 | 696 | 2016 |
In vivo CRISPR editing with no detectable genome-wide off-target mutations P Akcakaya, ML Bobbin, JA Guo, J Malagon-Lopez, K Clement, SP Garcia, ... Nature 561 (7723), 416-419, 2018 | 331 | 2018 |
MITF and UV responses in skin: From pigmentation to addiction NT Nguyen, DE Fisher Pigment cell & melanoma research 32 (2), 224-236, 2019 | 122 | 2019 |
Cancer immunotherapy based on image-guided STING activation by nucleotide nanocomplex-decorated ultrasound microbubbles X Li, S Khorsandi, Y Wang, J Santelli, K Huntoon, N Nguyen, M Yang, ... Nature nanotechnology 17 (8), 891-899, 2022 | 85 | 2022 |
Defining CRISPR–Cas9 genome-wide nuclease activities with CIRCLE-seq CR Lazzarotto, NT Nguyen, X Tang, J Malagon-Lopez, JA Guo, MJ Aryee, ... Nature protocols 13 (11), 2615-2642, 2018 | 83 | 2018 |
Gain-of-function genetic alterations of G9a drive oncogenesis S Kato, QY Weng, ML Insco, KY Chen, S Muralidhar, J Pozniak, JMS Diaz, ... Cancer discovery 10 (7), 980-997, 2020 | 51 | 2020 |
NNT mediates redox-dependent pigmentation via a UVB-and MITF-independent mechanism J Allouche, I Rachmin, K Adhikari, LM Pardo, JH Lee, AM McConnell, ... Cell 184 (16), 4268-4283. e20, 2021 | 42 | 2021 |
GSTM1 deletion exaggerates kidney injury in experimental mouse models and confers the protective effect of cruciferous vegetables in mice and humans JC Gigliotti, A Tin, S Pourafshar, S Cechova, YT Wang, JS Sun-sang, ... Journal of the American Society of Nephrology 31 (1), 102-116, 2020 | 36 | 2020 |
Defining genome-wide CRISPR–Cas genome-editing nuclease activity with GUIDE-seq NL Malinin, GH Lee, CR Lazzarotto, Y Li, Z Zheng, NT Nguyen, M Liebers, ... Nature protocols 16 (12), 5592-5615, 2021 | 34 | 2021 |
IBT-V02: A Multicomponent Toxoid Vaccine Protects Against Primary and Secondary Skin Infections Caused by Staphylococcus aureus H Karauzum, A Venkatasubramaniam, RP Adhikari, T Kort, FW Holtsberg, ... Frontiers in Immunology 12, 624310, 2021 | 23 | 2021 |
731. High-fidelity CRISPR-Cas9 nucleases with no detectable genome-wide off-target effects BP Kleinstiver, V Pattanayak, MS Prew, SQ Tsai, NT Nguyen, JK Joung Molecular Therapy 24, S288, 2016 | 21 | 2016 |
Broadening Staphylococcus aureus Cas9 targeting range by modifying PAM recognition BP Kleinstiver, MS Prew, SQ Tsai, NT Nguyen, VV Topkar, Z Zheng, ... Nature biotechnology 33 (12), 1293, 2015 | 8 | 2015 |
Phylogenetic relationship of tropical Asian Ardisia and relatives (Primulaceae) shows non-monophyly of recognized genera and subgenera A Julius, JS Gutiérrez-Ortega, S Sabran, S Tagane, A Naiki, D Darnaedi, ... Shokubutsu Kenkyu Zasshi 93, 149-165, 2021 | 7 | 2021 |
Loss of G0/G1 switch gene 2 (G0S2) promotes disease progression and drug resistance in chronic myeloid leukaemia (CML) by disrupting glycerophospholipid metabolism MA Gonzalez, IM Olivas, AE Bencomo‐Alvarez, AJ Rubio, ... Clinical and Translational Medicine 12 (12), e1146, 2022 | 4 | 2022 |
Correction: Corrigendum: CIRCLE-seq: a highly sensitive in vitro screen for genome-wide CRISPR–Cas9 nuclease off-targets SQ Tsai, NT Nguyen, J Malagon-Lopez, VV Topkar, MJ Aryee, JK Joung Nature Methods 15 (5), 394-394, 2018 | 2 | 2018 |