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Richard Knowles
Richard Knowles
Knowles Consulting
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Nitric oxide synthases: structure, function and inhibition
WK Alderton, CE Cooper, RG Knowles
Biochemical journal 357 (3), 593-615, 2001
56962001
Nitric oxide synthases in mammals.
RG Knowles, S Moncada
Biochemical Journal 298 (Pt 2), 249, 1994
38821994
Formation of nitric oxide from L-arginine in the central nervous system: a transduction mechanism for stimulation of the soluble guanylate cyclase.
RG Knowles, M Palacios, RM Palmer, S Moncada
Proceedings of the National Academy of Sciences 86 (13), 5159-5162, 1989
18611989
Induction of calcium-dependent nitric oxide synthases by sex hormones.
CP Weiner, I Lizasoain, SA Baylis, RG Knowles, IG Charles, S Moncada
Proceedings of the National Academy of Sciences 91 (11), 5212-5216, 1994
14251994
1400W is a slow, tight binding, and highly selective inhibitor of inducible nitric-oxide synthase in vitro and in vivo
EP Garvey, JA Oplinger, ES Furfine, RJ Kiff, F Laszlo, BJR Whittle, ...
Journal of Biological Chemistry 272 (8), 4959-4963, 1997
10111997
Nitric oxide synthase activity in human breast cancer
LL Thomsen, DW Miles, L Happerfield, LG Bobrow, RG Knowles, ...
British journal of cancer 72 (1), 41-44, 1995
8421995
Widespread tissue distribution, species distribution and changes in activity of Ca2+‐dependent and Ca2+‐independent nitric oxide synthases
M Salter, RG Knowles, S Moncada
FEBS letters 291 (1), 145-149, 1991
7881991
Nitric oxide synthase activity in human gynecological cancer
LL Thomsen, FG Lawton, RG Knowles, JE Beesley, V Riveros-Moreno, ...
Cancer research 54 (5), 1352-1354, 1994
6241994
Anti-inflammatory glucocorticoids inhibit the induction by endotoxin of nitric oxide synthase in the lung, liver and aorta of the rat
RG Knowles, M Salter, SL Brooks, S Moncada
Biochemical and biophysical research communications 172 (3), 1042-1048, 1990
5111990
Differential induction of brain, lung and liver nitric oxide synthase by endotoxin in the rat.
RG Knowles, M Merrett, M Salter, S Moncada
Biochemical Journal 270 (3), 833, 1990
4941990
Nitric oxide as a signal in blood vessels
RG Knowles, S Moncada
Trends in biochemical sciences 17 (10), 399-402, 1992
4541992
Constitutive and inducible nitric oxide synthases incorporate molecular oxygen into both nitric oxide and citrulline.
AM Leone, RM Palmer, RG Knowles, PL Francis, DS Ashton, S Moncada
Journal of Biological Chemistry 266 (35), 23790-23795, 1991
4021991
Nitric oxide and peroxynitrite exert distinct effects on mitochondrial respiration which are differentially blocked by glutathione or glucose
I LIZASOAIN, MA MORO, RG KNOWLES, V DARLEY-USMAR, ...
Biochemical Journal 314 (3), 877-880, 1996
3991996
Nitric oxide from L-arginine stimulates the soluble guanylate cyclase in adrenal glands
M Palacios, RG Knowles, RMJ Palmer, S Moncada
Biochemical and biophysical research communications 165 (2), 802-809, 1989
3341989
U-BIOPRED clinical adult asthma clusters linked to a subset of sputum omics
D Lefaudeux, B De Meulder, MJ Loza, N Peffer, A Rowe, F Baribaud, ...
Journal of Allergy and Clinical Immunology 139 (6), 1797-1807, 2017
2902017
Potent and selective inhibition of human nitric oxide synthases. Selective inhibition of neuronal nitric oxide synthase by S-methyl-L-thiocitrulline and S-ethyl-L-thiocitrulline.
ES Furfine, MF Harmon, JE Paith, RG Knowles, M Salter, RJ Kiff, C Duffy, ...
Journal of Biological Chemistry 269 (43), 26677-26683, 1994
2661994
Selective Inhibition of Inducible Nitric Oxide Synthase Inhibits Tumor Growth in Vivo: Studies with 1400W, a Novel Inhibitor
LL Thomsen, JMJ Scott, P Topley, RG Knowles, AJ Keerie, AJ Frend
Cancer research 57 (15), 3300-3304, 1997
2651997
Kinetic characteristics of nitric oxide synthase from rat brain
RG Knowles, M Palacios, RMJ Palmer, S Moncada
Biochemical Journal 269 (1), 207-210, 1990
2641990
The formation of nitric oxide donors from peroxynitrite
MÁ Moro, VM Darley‐Usmar, I Lizasoain, Y Su, RG Knowles, S Moncada, ...
British journal of pharmacology 116 (3), 1999-2004, 1995
2401995
Induction of nitric oxide synthases early in pregnancy
CP Weiner, RG Knowles, S Moncada
American journal of obstetrics and gynecology 171 (3), 838-843, 1994
2131994
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