| Crystallographic and electrophilic fragment screening of the SARS-CoV-2 main protease A Douangamath, D Fearon, P Gehrtz, T Krojer, P Lukacik, CD Owen, ... Nature communications 11 (1), 5047, 2020 | 435 | 2020 |
| An Experimental and in Situ IR Spectroscopic Study of the Lithiation–Substitution of N-Boc-2-phenylpyrrolidine and -piperidine: Controlling the Formation of … NS Sheikh, D Leonori, G Barker, JD Firth, KR Campos, AJHM Meijer, ... Journal of the American Chemical Society 134 (11), 5300-5308, 2012 | 115 | 2012 |
| Diastereoselective synthesis of 4-hydroxypiperidin-2-ones via Cu (I)-catalyzed reductive aldol cyclization HW Lam, GJ Murray, JD Firth Organic letters 7 (25), 5743-5746, 2005 | 96 | 2005 |
| A need for caution in the preparation and application of synthetically versatile aryl diazonium tetrafluoroborate salts JD Firth, IJS Fairlamb Organic Letters 22 (18), 7057-7059, 2020 | 85 | 2020 |
| Synthesis of Enantiopure Piperazines via Asymmetric Lithiation–Trapping of N-Boc Piperazines: Unexpected Role of the Electrophile and Distal N-Substituent JD Firth, P O’Brien, L Ferris Journal of the American Chemical Society 138 (2), 651-659, 2016 | 68 | 2016 |
| Increase of enzyme activity through specific covalent modification with fragments JF Darby, M Atobe, JD Firth, P Bond, GJ Davies, P O'Brien, RE Hubbard Chemical science 8 (11), 7772-7779, 2017 | 42 | 2017 |
| Design and Synthesis of 56 Shape‐Diverse 3D Fragments TD Downes, SP Jones, HF Klein, MC Wheldon, M Atobe, PS Bond, ... Chemistry (Weinheim an der Bergstrasse, Germany) 26 (41), 8969, 2020 | 41 | 2020 |
| Gram‐Scale Synthesis of the (−)‐Sparteine Surrogate and (−)‐Sparteine JD Firth, SJ Canipa, L Ferris, P O'Brien Angewandte Chemie International Edition 57 (1), 223-226, 2018 | 40 | 2018 |
| A biosynthesis-inspired approach to over twenty diverse natural product-like scaffolds GE Philip Chemical communications 52 (63), 9837-9840, 2016 | 33 | 2016 |
| Cross‐Coupling Knows No Limits: Assessing the Synthetic Potential of the Palladium‐Catalysed Cross‐Coupling of Organolithiums JD Firth, P O'Brien ChemCatChem 7 (3), 395-397, 2015 | 27 | 2015 |
| Revisiting the sparteine surrogate: development of a resolution route to the (−)-sparteine surrogate JD Firth, P O'Brien, L Ferris Organic & Biomolecular Chemistry 12 (46), 9357-9365, 2014 | 26 | 2014 |
| [1, 2, 4] triazolo [1, 5-a] pyridine and [1, 2, 4] triazolo [1, 5-c] pyrimidine compounds and their use GA Pavé, JD Firth, L Stewart, LJM Rigoreau, EL Wynne US Patent 8,431,596, 2013 | 24 | 2013 |
| Exploitation of the Ugi–Joullié reaction in the synthesis of libraries of drug-like bicyclic hydantoins JD Firth, R Zhang, R Morgentin, R Guilleux, T Kalliokoski, S Warriner, ... Synthesis, 2391-2406, 2015 | 23 | 2015 |
| Light‐and Manganese‐Initiated Borylation of Aryl Diazonium Salts: Mechanistic Insight on the Ultrafast Time‐Scale Revealed by Time‐Resolved Spectroscopic Analysis JD Firth, LA Hammarback, TJ Burden, JB Eastwood, JR Donald, ... Chemistry–A European Journal 27 (12), 3979-3985, 2021 | 15 | 2021 |
| General Procedures for the Lithiation/Trapping of N-Boc Piperazines JD Firth, P O’Brien, L Ferris The Journal of organic chemistry 82 (13), 7023-7031, 2017 | 13 | 2017 |
| Rapid “high” temperature batch and flow lithiation-trapping of N-Boc pyrrolidine A Kwong, JD Firth, TJ Farmer, P O’Brien Tetrahedron 81, 131899, 2021 | 8 | 2021 |
| Crystallographic and electrophilic fragment screening of the SARS-CoV-2 main protease, Nat. Commun., 11, 5047 A Douangamath, D Fearon, P Gehrtz, T Krojer, P Lukacik, CD Owen, ... | 7 | 2020 |
| Synthesis and functionalisation of a bifunctional normorphan 3D building block for medicinal chemistry AR Gomez-Angel, JR Donald, JD Firth, C De Fusco, RI Storer, DJ Cox, ... Tetrahedron 83, 131961, 2021 | 4 | 2021 |
| Fragment-derived modulators of an industrial β-glucosidase E Makraki, JF Darby, MG Carneiro, JD Firth, A Heyam, E Ab, P O'Brien, ... Biochemical Journal 477 (22), 4383-4395, 2020 | 3 | 2020 |
| Lead-and fragment-oriented synthesis JD Firth, P O'Brien | 3 | 2018 |
