| Structure and mechanism of an amino acid antiporter X Gao, F Lu, L Zhou, S Dang, L Sun, X Li, J Wang, Y Shi Science 324 (5934), 1565-1568, 2009 | 248 | 2009 |
| Mechanism of substrate recognition and transport by an amino acid antiporter X Gao, L Zhou, X Jiao, F Lu, C Yan, X Zeng, J Wang, Y Shi Nature 463 (7282), 828-832, 2010 | 222 | 2010 |
| Crystal structures of the Lsm complex bound to the 3′ end sequence of U6 small nuclear RNA L Zhou, J Hang, Y Zhou, R Wan, G Lu, P Yin, C Yan, Y Shi Nature 506 (7486), 116-120, 2014 | 100 | 2014 |
| A model for the emergence of RNA from a prebiotically plausible mixture of ribonucleotides, arabinonucleotides, and 2′-deoxynucleotides SC Kim, L Zhou, W Zhang, DK O’Flaherty, V Rondo-Brovetto, JW Szostak Journal of the American Chemical Society 142 (5), 2317-2326, 2020 | 54 | 2020 |
| Inosine, but none of the 8-oxo-purines, is a plausible component of a primordial version of RNA SC Kim, DK O’Flaherty, L Zhou, VS Lelyveld, JW Szostak Proceedings of the National Academy of Sciences 115 (52), 13318-13323, 2018 | 48 | 2018 |
| Non-enzymatic primer extension with strand displacement L Zhou, SC Kim, KH Ho, DK O'Flaherty, C Giurgiu, TH Wright, JW Szostak Elife 8, e51888, 2019 | 47 | 2019 |
| Template‐directed copying of RNA by non‐enzymatic ligation L Zhou, DK O'Flaherty, JW Szostak Angewandte Chemie 132 (36), 15812-15817, 2020 | 44 | 2020 |
| The virtual circular genome model for primordial RNA replication L Zhou, D Ding, JW Szostak Rna 27 (1), 1-11, 2021 | 41 | 2021 |
| Nonenzymatic template-directed synthesis of mixed-sequence 3′-NP-DNA up to 25 nucleotides long inside model protocells DK O’Flaherty, L Zhou, JW Szostak Journal of the American Chemical Society 141 (26), 10481-10488, 2019 | 34 | 2019 |
| Assembly of a ribozyme ligase from short oligomers by nonenzymatic ligation L Zhou, DK O’Flaherty, JW Szostak Journal of the American Chemical Society 142 (37), 15961-15965, 2020 | 31 | 2020 |
| The emergence of RNA from the heterogeneous products of prebiotic nucleotide synthesis SC Kim, DK O’Flaherty, C Giurgiu, L Zhou, JW Szostak Journal of the American Chemical Society 143 (9), 3267-3279, 2021 | 26 | 2021 |
| Structural rationale for the enhanced catalysis of nonenzymatic RNA primer extension by a downstream oligonucleotide W Zhang, CP Tam, L Zhou, SS Oh, J Wang, JW Szostak Journal of the American Chemical Society 140 (8), 2829-2840, 2018 | 26 | 2018 |
| Kinetic explanations for the sequence biases observed in the nonenzymatic copying of RNA templates D Ding, L Zhou, C Giurgiu, JW Szostak Nucleic Acids Research 50 (1), 35-45, 2022 | 21 | 2022 |
| Crystal structure and biochemical analysis of the heptameric Lsm1-7 complex L Zhou, Y Zhou, J Hang, R Wan, G Lu, C Yan, Y Shi Cell Research 24 (4), 497-500, 2014 | 21 | 2014 |
| Prebiotically plausible “patching” of RNA backbone cleavage through a 3′–5′ pyrophosphate linkage TH Wright, C Giurgiu, W Zhang, A Radakovic, DK O’Flaherty, L Zhou, ... Journal of the American Chemical Society 141 (45), 18104-18112, 2019 | 20 | 2019 |
| Heterodimerization of UNC-13/RIM regulates synaptic vesicle release probability but not priming in C. elegans H Liu, L Li, D Nedelcu, Q Hall, L Zhou, W Wang, Y Yu, JM Kaplan, Z Hu Elife 8, e40585, 2019 | 19 | 2019 |
| Synthesis of a nonhydrolyzable nucleotide phosphoroimidazolide analogue that catalyzes nonenzymatic RNA primer extension CP Tam, L Zhou, AC Fahrenbach, W Zhang, T Walton, JW Szostak Journal of the American Chemical Society 140 (2), 783-792, 2018 | 12 | 2018 |
| DNA polymerase activity on synthetic N3′→ P5′ phosphoramidate DNA templates VS Lelyveld, DK O’Flaherty, L Zhou, EC Izgu, JW Szostak Nucleic acids research 47 (17), 8941-8949, 2019 | 9 | 2019 |
| Experimental tests of the virtual circular genome model for nonenzymatic RNA replication D Ding, L Zhou, S Mittal, JW Szostak Journal of the American Chemical Society 145 (13), 7504-7515, 2023 | 7 | 2023 |
| Assembly of a functional ribozyme from short oligomers by enhanced non-enzymatic ligation L Zhou, DK O’Flaherty, JW Szostak bioRxiv, 700229, 2019 | 3 | 2019 |
Jack W. SzostakMassachusetts General Hospital, Harvard, HHMIVerified email at molbio.mgh.harvard.edu
