Liposome-mediated CFTR gene transfer to the nasal epithelium of patients with cystic fibrosis NJ Caplen, EWFW Alton, PG Mddleton, JR Dorin, BJ Stevenson, X Gao, ... Nature medicine 1 (1), 39-46, 1995 | 975 | 1995 |
Liposome-mediated CFTR gene transfer to the nasal epithelium of patients with cystic fibrosis NJ Caplen, EWFW Alton, PG Mddleton, JR Dorin, BJ Stevenson, X Gao, ... Nature medicine 1 (1), 39-46, 1995 | 975 | 1995 |
Cationic lipid-mediated CFTR gene transfer to the lungs and nose of patients with cystic fibrosis: a double-blind placebo-controlled trial E Alton, M Stern, R Farley, A Jaffe, SL Chadwick, J Phillips, J Davies, ... The Lancet 353 (9157), 947-954, 1999 | 563 | 1999 |
Non–invasive liposome–mediated gene delivery can correct the ion transport defect in cystic fibrosis mutant mice E Alton, PG Middleton, NJ Caplen, SN Smith, DM Steel, FM Munkonge, ... Nature genetics 5 (2), 135-142, 1993 | 536 | 1993 |
Non–invasive liposome–mediated gene delivery can correct the ion transport defect in cystic fibrosis mutant mice E Alton, PG Middleton, NJ Caplen, SN Smith, DM Steel, FM Munkonge, ... Nature genetics 5 (2), 135-142, 1993 | 536 | 1993 |
Repeated nebulisation of non-viral CFTR gene therapy in patients with cystic fibrosis: a randomised, double-blind, placebo-controlled, phase 2b trial EWFW Alton, DK Armstrong, D Ashby, KJ Bayfield, D Bilton, ... The Lancet Respiratory Medicine 3 (9), 684-691, 2015 | 503 | 2015 |
Repeated nebulisation of non-viral CFTR gene therapy in patients with cystic fibrosis: a randomised, double-blind, placebo-controlled, phase 2b trial EWFW Alton, DK Armstrong, D Ashby, KJ Bayfield, D Bilton, ... The Lancet Respiratory Medicine 3 (9), 684-691, 2015 | 503 | 2015 |
Cystic fibrosis in the mouse by targeted insertional mutagenesis JR Dorin, P Dickinson, EWFW Alton, SN Smith, DM Geddes, ... Nature 359 (6392), 211-215, 1992 | 385 | 1992 |
CpG-free plasmids confer reduced inflammation and sustained pulmonary gene expression SC Hyde, IA Pringle, S Abdullah, AE Lawton, LA Davies, A Varathalingam, ... Nature biotechnology 26 (5), 549-551, 2008 | 371 | 2008 |
Efficient gene transfer to airway epithelium using recombinant Sendai virus Y Yonemitsu, C Kitson, S Ferrari, R Farley, U Griesenbach, D Judd, ... Nature biotechnology 18 (9), 970-973, 2000 | 291 | 2000 |
Lung clearance index is a sensitive, repeatable and practical measure of airways disease in adults with cystic fibrosis AR Horsley, PM Gustafsson, KA Macleod, C Saunders, AP Greening, ... Thorax 63 (2), 135-140, 2008 | 279 | 2008 |
In vitro liposome-mediated DNA transfection of epithelial cell lines using the cationic liposome DC-Chol/DOPE. NJ Caplen, E Kinrade, F Sorgi, X Gao, D Gruenert, D Geddes, C Coutelle, ... Gene Therapy 2 (9), 603-613, 1995 | 230 | 1995 |
Barriers to and new approaches for gene therapy and gene delivery in cystic fibrosis S Ferrari, DM Geddes, EWFW Alton Advanced drug delivery reviews 54 (11), 1373-1393, 2002 | 222 | 2002 |
Increased airway smooth muscle mass in children with asthma, cystic fibrosis, and non-cystic fibrosis bronchiectasis N Regamey, M Ochs, TN Hilliard, C Mühlfeld, N Cornish, L Fleming, ... American journal of respiratory and critical care medicine 177 (8), 837-843, 2008 | 195 | 2008 |
Protocols for in vivo measurement of the ion transport defects in cystic fibrosis nasal epithelium PG Middleton, DM Geddes, EW Alton European Respiratory Journal 7 (11), 2050-2056, 1994 | 189 | 1994 |
Gene transfer to the lung: lessons learned from more than 2 decades of CF gene therapy U Griesenbach, EWFW Alton, ... Advanced drug delivery reviews 61 (2), 128-139, 2009 | 183 | 2009 |
A demonstration using mouse models that successful gene therapy for cystic fibrosis requires only partial gene correction. JR Dorin, R Farley, S Webb, SN Smith, E Farini, SJ Delaney, ... Gene therapy 3 (9), 797-801, 1996 | 178 | 1996 |
Magnetic nanoparticles as gene delivery agents: enhanced transfection in the presence of oscillating magnet arrays SC McBain, U Griesenbach, S Xenariou, A Keramane, CD Batich, E Alton, ... Nanotechnology 19 (40), 405102, 2008 | 168 | 2008 |
Cystic fibrosis mice carrying the missense mutation G551D replicate human genotype‐phenotype correlations. SJ Delaney, EW Alton, SN Smith, DP Lunn, R Farley, PK Lovelock, ... The EMBO journal 15 (5), 955-963, 1996 | 168 | 1996 |
The extra-and intracellular barriers to lipid and adenovirus-mediated pulmonary gene transfer in native sheep airway epithelium C Kitson, B Angel, D Judd, S Rothery, NJ Severs, A Dewar, L Huang, ... Gene therapy 6 (4), 534-546, 1999 | 167 | 1999 |